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- W2908377373 abstract "Tissue-specific differential post-translational processing mechanisms represent a set of strategies for generating discrete subsets of polypeptide end-products from a common precursor. The isolation and characterization of POMC mRNA from the bovine pituitary, unequivocally established that corticotropin-related peptides and lipotropin-related peptides are synthesized from a common precursor. Prior to the isolation and characterization of POMC mRNA from bovine pituitary, several biochemical studies had presented evidence that corticotropin-related peptides and lipotropin-related peptides were synthesized from a common precursor. The biosynthetic intermediate, 16 K fragment contains the sequence of gamma-melanotropin. The existence of this third melanotropin sequence was only revealed following the characterization of bovine POMC mRNA. The function of this “melanotropin” is unclear. Synthetic bovine gamma-melanocyte-stimulating hormone (MSH) analogs have been tested in a variety of melanotropin bioassay systems. Alpha-MSH has been characterized in several species of nonmammalian vertebrates. The N-acetylation of alpha-MSH and beta-endorphin in the pars intermedia has a significant effect on the biological activity of these polypeptides." @default.
- W2908377373 created "2019-01-11" @default.
- W2908377373 creator A5067636916 @default.
- W2908377373 date "2018-01-18" @default.
- W2908377373 modified "2023-09-28" @default.
- W2908377373 title "Pituitary Melanotropin Biosynthesis" @default.
- W2908377373 doi "https://doi.org/10.1201/9781351074391-3" @default.
- W2908377373 hasPublicationYear "2018" @default.
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