Matches in SemOpenAlex for { <https://semopenalex.org/work/W2908393381> ?p ?o ?g. }
- W2908393381 abstract "Endothelial cell (EC) sensing of fluid shear stress direction is a critical determinant of vascular health and disease. Unidirectional flow induces EC alignment and vascular homeostasis, whereas bidirectional flow has pathophysiological effects. EC express several mechanoreceptors that respond to flow but the mechanism for sensing shear stress direction is poorly understood. We observed using in vitro flow systems and magnetic tweezers that β1 integrin is a key sensor of force direction because it is activated by unidirectional but not bidirectional shearing forces. β1 integrin activation by unidirectional force was amplified in EC that were pre-sheared in the same direction, indicating that alignment and β1 integrin activity has a feedforward interaction which is a hallmark of system stability. En face staining and EC-specific genetic deletion studies of the murine aorta revealed that β1 integrin is activated and is essential for EC alignment at sites of unidirectional flow but is not activated at sites of bidirectional flow. In summary, β1 integrin sensing of unidirectional force is a key mechanism for decoding blood flow mechanics to promote vascular homeostasis." @default.
- W2908393381 created "2019-01-11" @default.
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- W2908393381 date "2019-01-01" @default.
- W2908393381 modified "2023-10-16" @default.
- W2908393381 title "β1 integrin is a sensor of blood flow direction" @default.
- W2908393381 cites W1559044733 @default.
- W2908393381 cites W1862715758 @default.
- W2908393381 cites W1970504214 @default.
- W2908393381 cites W1972436525 @default.
- W2908393381 cites W1973032213 @default.
- W2908393381 cites W1983897833 @default.
- W2908393381 cites W1999765951 @default.
- W2908393381 cites W2002350611 @default.
- W2908393381 cites W2003801710 @default.
- W2908393381 cites W2004872903 @default.
- W2908393381 cites W2007097623 @default.
- W2908393381 cites W2010546098 @default.
- W2908393381 cites W2014926635 @default.
- W2908393381 cites W2018849626 @default.
- W2908393381 cites W2020732104 @default.
- W2908393381 cites W2020925072 @default.
- W2908393381 cites W2023302566 @default.
- W2908393381 cites W2029182395 @default.
- W2908393381 cites W2037226238 @default.
- W2908393381 cites W2049536857 @default.
- W2908393381 cites W2053627692 @default.
- W2908393381 cites W2055279538 @default.
- W2908393381 cites W2057477511 @default.
- W2908393381 cites W2067174909 @default.
- W2908393381 cites W2067573008 @default.
- W2908393381 cites W2077735761 @default.
- W2908393381 cites W2081693079 @default.
- W2908393381 cites W2090106721 @default.
- W2908393381 cites W2091314328 @default.
- W2908393381 cites W2096357860 @default.
- W2908393381 cites W2096954246 @default.
- W2908393381 cites W2099219058 @default.
- W2908393381 cites W2099330106 @default.
- W2908393381 cites W2100885587 @default.
- W2908393381 cites W2102571827 @default.
- W2908393381 cites W2105496404 @default.
- W2908393381 cites W2109947902 @default.
- W2908393381 cites W2120243513 @default.
- W2908393381 cites W2120556384 @default.
- W2908393381 cites W2121278567 @default.
- W2908393381 cites W2125764697 @default.
- W2908393381 cites W2130180308 @default.
- W2908393381 cites W2131882767 @default.
- W2908393381 cites W2133515086 @default.
- W2908393381 cites W2137224035 @default.
- W2908393381 cites W2138695033 @default.
- W2908393381 cites W2139615023 @default.
- W2908393381 cites W2141260105 @default.
- W2908393381 cites W2141643986 @default.
- W2908393381 cites W2143987563 @default.
- W2908393381 cites W2148038169 @default.
- W2908393381 cites W2148245148 @default.
- W2908393381 cites W2153688789 @default.
- W2908393381 cites W2157122108 @default.
- W2908393381 cites W2161054601 @default.
- W2908393381 cites W2161987522 @default.
- W2908393381 cites W2224336164 @default.
- W2908393381 cites W2294118174 @default.
- W2908393381 cites W2334498364 @default.
- W2908393381 cites W2419329326 @default.
- W2908393381 cites W2433805774 @default.
- W2908393381 cites W2516557409 @default.
- W2908393381 cites W2531514859 @default.
- W2908393381 cites W2582873639 @default.
- W2908393381 cites W2740101983 @default.
- W2908393381 cites W2763146615 @default.
- W2908393381 cites W2786247139 @default.
- W2908393381 cites W2890154816 @default.
- W2908393381 cites W2908411370 @default.
- W2908393381 cites W2950669024 @default.
- W2908393381 cites W748827547 @default.
- W2908393381 cites W274441265 @default.
- W2908393381 doi "https://doi.org/10.1242/jcs.229542" @default.
- W2908393381 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6589088" @default.
- W2908393381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31076511" @default.
- W2908393381 hasPublicationYear "2019" @default.
- W2908393381 type Work @default.