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• W2908425005 endingPage "1911" @default.
• W2908425005 startingPage "1904" @default.
• W2908425005 abstract "Biothiols are essential reactive sulfur species (RSS), which play crucial roles in various critical physiological activities. To clarify their complex correlations in signal transduction and metabolism pathways, methods to distinguish H2S, cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) at the same time are highly needed. Herein, we deliberately integrate 7-diethylcoumarin and resorufin through an ether bond to develop RC for simultaneous differentiation of Cys, Hcy, GSH, and H2S for the first time. RC displays distinct fluorescence colors in response to H2S, Cys, Hcy, and GSH as red, blue-red, blue-green-red, and green-red, respectively, both in aqueous media and living cells. This work not only reported a robust molecule, RC, to disentangle the intricate interplay networks among different biothiols in biosystems but also demonstrated a strategy for the design of multisignal fluorescent probes for the simultaneous sensing of diverse RSS species as well as other biological species." @default.
• W2908425005 created "2019-01-11" @default.
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• W2908425005 date "2018-12-28" @default.
• W2908425005 modified "2023-10-16" @default.
• W2908425005 title "Simultaneous Discrimination of Cysteine, Homocysteine, Glutathione, and H₂S in Living Cells through a Multisignal Combination Strategy" @default.
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• W2908425005 doi "https://doi.org/10.1021/acs.analchem.8b03869" @default.
• W2908425005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30592207" @default.
• W2908425005 hasPublicationYear "2018" @default.
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