FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2908458052> ?p ?o ?g. }

• W2908458052 endingPage "38" @default.
• W2908458052 startingPage "30" @default.
• W2908458052 abstract "Diabetic patients are at an increased risk of developing severe and progressive periodontitis. Periodontal disease also increases the severity of diabetes by enhancing insulin resistance. Therefore, the regulation of periodontal inflammation in diabetic patients may contribute to the control of both diseases. Glycyrrhizic acid exerts anti-inflammatory effects by inhibiting high mobility group box 1 (HMGB1). HMGB1, one of the ligands of the receptor for advanced glycation end products (RAGE), is a damage-associated molecular pattern and induces inflammatory cytokine production. In the present study, we examined the effects of glycyrrhizic acid on ligature- and Porphyromonas gulae infection-induced periodontitis as well as the involvement of the HMGB1-RAGE axis in diabetic model mice. The molars of diabetic model mice, established by feeding HFD32 to KK/TaJcl mice, were subjected to silk thread ligation and P. gulae was then intraorally applied in the presence or absence of glycyrrhizic acid given topically. The topical application of glycyrrhizic acid suppressed ligature/P. gulae-induced increases in interleukin (IL)-6 and tumor necrosis factor (TNF)-α at the mRNA level in the gingiva and at the protein level in serum. Furthermore, glycyrrhizic acid suppressed ligature/P. gulae-induced increases in serum amyloid A (SAA) in serum and fasting blood glucose levels. It also suppressed ligature/P. gulae-induced increases of HMGB1 and RAGE at the mRNA level in the gingiva and at the protein level in serum. A mouse anti-HMGB1-neutralizing antibody inhibited increases in serum glucose levels. In conclusion, topical treatments with glycyrrhizic acid may suppress periodontal and systemic inflammation and reduce blood glucose levels through the HMGB1-RAGE axis in diabetic mice." @default.
• W2908458052 created "2019-01-11" @default.
• W2908458052 creator A5000175362 @default.
• W2908458052 creator A5002033800 @default.
• W2908458052 creator A5008653591 @default.
• W2908458052 creator A5029830408 @default.
• W2908458052 creator A5033901129 @default.
• W2908458052 creator A5040863675 @default.
• W2908458052 creator A5045606633 @default.
• W2908458052 creator A5050341064 @default.
• W2908458052 creator A5070040943 @default.
• W2908458052 creator A5071433700 @default.
• W2908458052 creator A5072734104 @default.
• W2908458052 date "2019-03-01" @default.
• W2908458052 modified "2023-10-02" @default.
• W2908458052 title "Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice" @default.
• W2908458052 cites W157415499 @default.
• W2908458052 cites W1976105610 @default.
• W2908458052 cites W1977347871 @default.
• W2908458052 cites W1980763614 @default.
• W2908458052 cites W1984022178 @default.
• W2908458052 cites W1996602846 @default.
• W2908458052 cites W1996813252 @default.
• W2908458052 cites W1999316977 @default.
• W2908458052 cites W2005714581 @default.
• W2908458052 cites W2018575169 @default.
• W2908458052 cites W2019132447 @default.
• W2908458052 cites W2020942709 @default.
• W2908458052 cites W2026885016 @default.
• W2908458052 cites W2031799324 @default.
• W2908458052 cites W2033346442 @default.
• W2908458052 cites W2034594119 @default.
• W2908458052 cites W2041883450 @default.
• W2908458052 cites W2042824462 @default.
• W2908458052 cites W2050138576 @default.
• W2908458052 cites W2050432013 @default.
• W2908458052 cites W2052992473 @default.
• W2908458052 cites W2060010080 @default.
• W2908458052 cites W2066583878 @default.
• W2908458052 cites W2088780149 @default.
• W2908458052 cites W2103224375 @default.
• W2908458052 cites W2107918642 @default.
• W2908458052 cites W2109590683 @default.
• W2908458052 cites W2115206790 @default.
• W2908458052 cites W2132707520 @default.
• W2908458052 cites W2136497196 @default.
• W2908458052 cites W2154534174 @default.
• W2908458052 cites W2155352329 @default.
• W2908458052 cites W2170754664 @default.
• W2908458052 cites W2171968999 @default.
• W2908458052 cites W2343509480 @default.
• W2908458052 cites W2515776554 @default.
• W2908458052 cites W2617526825 @default.
• W2908458052 cites W2789626341 @default.
• W2908458052 cites W4238497443 @default.
• W2908458052 cites W4240182676 @default.
• W2908458052 cites W4249727000 @default.
• W2908458052 doi "https://doi.org/10.1016/j.intimp.2018.12.045" @default.
• W2908458052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30599445" @default.
• W2908458052 hasPublicationYear "2019" @default.
• W2908458052 type Work @default.
• W2908458052 sameAs 2908458052 @default.
• W2908458052 citedByCount "32" @default.
• W2908458052 countsByYear W29084580522019 @default.
• W2908458052 countsByYear W29084580522020 @default.
• W2908458052 countsByYear W29084580522021 @default.
• W2908458052 countsByYear W29084580522022 @default.
• W2908458052 countsByYear W29084580522023 @default.
• W2908458052 crossrefType "journal-article" @default.
• W2908458052 hasAuthorship W2908458052A5000175362 @default.
• W2908458052 hasAuthorship W2908458052A5002033800 @default.
• W2908458052 hasAuthorship W2908458052A5008653591 @default.
• W2908458052 hasAuthorship W2908458052A5029830408 @default.
• W2908458052 hasAuthorship W2908458052A5033901129 @default.
• W2908458052 hasAuthorship W2908458052A5040863675 @default.
• W2908458052 hasAuthorship W2908458052A5045606633 @default.
• W2908458052 hasAuthorship W2908458052A5050341064 @default.
• W2908458052 hasAuthorship W2908458052A5070040943 @default.
• W2908458052 hasAuthorship W2908458052A5071433700 @default.
• W2908458052 hasAuthorship W2908458052A5072734104 @default.
• W2908458052 hasConcept C126322002 @default.
• W2908458052 hasConcept C134018914 @default.
• W2908458052 hasConcept C147990577 @default.
• W2908458052 hasConcept C169760540 @default.
• W2908458052 hasConcept C185592680 @default.
• W2908458052 hasConcept C2776914184 @default.
• W2908458052 hasConcept C2776997535 @default.
• W2908458052 hasConcept C2777998629 @default.
• W2908458052 hasConcept C2778857457 @default.
• W2908458052 hasConcept C2780183776 @default.
• W2908458052 hasConcept C2780385504 @default.
• W2908458052 hasConcept C2780545709 @default.
• W2908458052 hasConcept C555293320 @default.
• W2908458052 hasConcept C71924100 @default.
• W2908458052 hasConcept C86803240 @default.
• W2908458052 hasConceptScore W2908458052C126322002 @default.
• W2908458052 hasConceptScore W2908458052C134018914 @default.
• W2908458052 hasConceptScore W2908458052C147990577 @default.

• next