FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2908459689> ?p ?o ?g. }

• W2908459689 abstract "The capacity of Mycobacterium tuberculosis (Mtb) to sense, respond and adapt to a variable and hostile environment within the host has made it one of the most successful human pathogens. During different stages of infection, Mtb is surrounded by a plethora of lipid rich molecules and current evidence points out the relevance of fatty acids during the infectious process. In this study, we have compared the transcriptional response of Mtb to hypoxia in cultures grown in both, a mix of either even long-chain fatty acids or dextrose as carbon sources. Using RNA sequencing, we have identified the differential expressed genes in early and late hypoxia defined according to the in vitro Wayne and Hayes model and compared the results with the exponential phase of growth in both carbon sources. Our results showed that, different to dextrose, the number of genes overexpressed in hypoxia in the lipid medium was quite low in both, early and late hypoxia in all functional categories described for Mtb. The exceptions were the transcripts of stable and non-coding RNAs which were more expressed in the fatty acid medium. We found that sigB and sigE were overexpressed in the early phase of hypoxia, confirming their pivotal role in early adaptation to low oxygen concentration independently of the carbon source. A drastic contrast was found with the transcriptional regulatory factors at early hypoxia. Only 2 transcriptional factors were overexpressed in early hypoxia in the lipid medium compared to 37 that were overexpressed in the dextrose medium. Instead of Rv0081, known to be the central regulator of hypoxia in dextrose, Rv2745c, (ClgR), is playing a main role in hypoxia in the fatty acids medium. The low level of genes associated to the stress-response, showed by Mtb during their adaptation to hypoxia in fatty acids, suggested that this lipid environment makes hypoxia a less stressful condition for the tubercle bacilli. Therefore, when the bacillus is surviving in that environment its metabolism seemed to be already adapted to different stresses within the host, including hypoxia. This fact could explain the success of Mtb to establish long-term survival during latent infection." @default.
• W2908459689 created "2019-01-11" @default.
• W2908459689 creator A5021824221 @default.
• W2908459689 creator A5028811878 @default.
• W2908459689 creator A5033749351 @default.
• W2908459689 creator A5035104530 @default.
• W2908459689 creator A5040260987 @default.
• W2908459689 creator A5046544300 @default.
• W2908459689 creator A5056341667 @default.
• W2908459689 creator A5059807170 @default.
• W2908459689 creator A5081128029 @default.
• W2908459689 creator A5081682354 @default.
• W2908459689 date "2019-01-09" @default.
• W2908459689 modified "2023-09-30" @default.
• W2908459689 title "Hypoxia Is Not a Main Stress When Mycobacterium tuberculosis Is in a Dormancy-Like Long-Chain Fatty Acid Environment" @default.
• W2908459689 cites W1499916435 @default.
• W2908459689 cites W1957134375 @default.
• W2908459689 cites W1966246756 @default.
• W2908459689 cites W1971997781 @default.
• W2908459689 cites W1981583421 @default.
• W2908459689 cites W1984523365 @default.
• W2908459689 cites W1990653290 @default.
• W2908459689 cites W1993966957 @default.
• W2908459689 cites W1994105525 @default.
• W2908459689 cites W1997914453 @default.
• W2908459689 cites W2008232376 @default.
• W2908459689 cites W2015498428 @default.
• W2908459689 cites W2017145164 @default.
• W2908459689 cites W2020125448 @default.
• W2908459689 cites W2020541351 @default.
• W2908459689 cites W2021476808 @default.
• W2908459689 cites W2023304660 @default.
• W2908459689 cites W2023985059 @default.
• W2908459689 cites W2040494217 @default.
• W2908459689 cites W2040694642 @default.
• W2908459689 cites W2051584259 @default.
• W2908459689 cites W2078663039 @default.
• W2908459689 cites W2083632051 @default.
• W2908459689 cites W2094222845 @default.
• W2908459689 cites W2110926912 @default.
• W2908459689 cites W2123084649 @default.
• W2908459689 cites W2124985265 @default.
• W2908459689 cites W2126326821 @default.
• W2908459689 cites W2130825211 @default.
• W2908459689 cites W2142410038 @default.
• W2908459689 cites W2144825193 @default.
• W2908459689 cites W2150342978 @default.
• W2908459689 cites W2152080623 @default.
• W2908459689 cites W2157737997 @default.
• W2908459689 cites W2158023121 @default.
• W2908459689 cites W2161366481 @default.
• W2908459689 cites W2163156346 @default.
• W2908459689 cites W2165214160 @default.
• W2908459689 cites W2166857331 @default.
• W2908459689 cites W2167156367 @default.
• W2908459689 cites W2169896356 @default.
• W2908459689 cites W2171840103 @default.
• W2908459689 cites W2280022909 @default.
• W2908459689 cites W2286159415 @default.
• W2908459689 cites W2303887217 @default.
• W2908459689 cites W2337253598 @default.
• W2908459689 cites W2338659600 @default.
• W2908459689 cites W2470116637 @default.
• W2908459689 cites W2479689221 @default.
• W2908459689 cites W2517328182 @default.
• W2908459689 cites W2529696598 @default.
• W2908459689 cites W2538911713 @default.
• W2908459689 cites W2550961289 @default.
• W2908459689 cites W2567377827 @default.
• W2908459689 cites W2599728656 @default.
• W2908459689 cites W2755134737 @default.
• W2908459689 cites W2762844642 @default.
• W2908459689 cites W2771168500 @default.
• W2908459689 cites W2797924506 @default.
• W2908459689 cites W2800885808 @default.
• W2908459689 cites W2804885321 @default.
• W2908459689 cites W386594400 @default.
• W2908459689 cites W4234395308 @default.
• W2908459689 cites W4242926467 @default.
• W2908459689 cites W4245626240 @default.
• W2908459689 doi "https://doi.org/10.3389/fcimb.2018.00449" @default.
• W2908459689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6333855" @default.
• W2908459689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30687646" @default.
• W2908459689 hasPublicationYear "2019" @default.
• W2908459689 type Work @default.
• W2908459689 sameAs 2908459689 @default.
• W2908459689 citedByCount "27" @default.
• W2908459689 countsByYear W29084596892019 @default.
• W2908459689 countsByYear W29084596892020 @default.
• W2908459689 countsByYear W29084596892021 @default.
• W2908459689 countsByYear W29084596892022 @default.
• W2908459689 countsByYear W29084596892023 @default.
• W2908459689 crossrefType "journal-article" @default.
• W2908459689 hasAuthorship W2908459689A5021824221 @default.
• W2908459689 hasAuthorship W2908459689A5028811878 @default.
• W2908459689 hasAuthorship W2908459689A5033749351 @default.
• W2908459689 hasAuthorship W2908459689A5035104530 @default.
• W2908459689 hasAuthorship W2908459689A5040260987 @default.
• W2908459689 hasAuthorship W2908459689A5046544300 @default.
• W2908459689 hasAuthorship W2908459689A5056341667 @default.

• next