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• W29084826 abstract "Heat acclimation (AC) is a within lifetime reversible phenotypic adaptation, enhancing thermotolerance and heat endurance via a transition to efficient cellular performance when acclimatory homeostasis is reached. An inseparable outcome of AC is the development of cross-tolerance (C-T) against novel stressors. This chapter focuses on central plasticity and the molecular-physiological linkage of acclimatory and C-T responses. A drop in temperature thresholds (T-Tsh) for activation of heat-dissipation mechanisms and an elevated T-Tsh for thermal injury development imply autonomic nervous system (ANS) and cytoprotective network involvement in these processes. During acclimation, the changes in T-Tsh for heat dissipation are biphasic. Initially T-Tsh drops, signifying the early autonomic response, and is associated with perturbed peripheral effector cellular performance. Pre-acclimation values return when acclimatory homeostasis is achieved. The changes in the ANS suggest that acclimatory plasticity involves molecular and cellular changes. These changes are manifested by the activation of central peripheral molecular networks and post-translational modifications. Sympathetic induction of elevated HSP 72 reservoirs, with faster heat shock response, is only one example of this. The global genomic response, detected using gene-chips and cluster analyses imply upregulation of genes encoding ion channels, pumps, and transporters (markers for neuronal excitability) in the hypothalamus at the onset of AC and down regulation of metabotrophic genes upon long term AC. Peripherally, the transcriptional program indicates a two-tier defense strategy. The immediate transient response is associated with the maintenance of DNA and cellular integrity. The sustained response correlates with long-lasting cytoprotective-signaling networks. C-T is recorded against cerebral hypoxia, hyperoxia, and traumatic brain injury. Using the highly developed ischemic/reperfused heart model as a baseline, it is evident that C-T stems via protective shared pathways developed with AC. These comprise constitutive elevation of HIF 1alpha and associated target pathways, HSPs, anti-apoptosis, and antioxidative pathways. Collectively the master regulators of AC and C-T are still enigmatic; however, cutting-edge investigative techniques, using a broad molecular approach, challenge current ideas, and the data accumulated will pinpoint novel pathways and provide new perspectives." @default.
• W29084826 created "2016-06-24" @default.
• W29084826 creator A5035023438 @default.
• W29084826 date "2007-01-01" @default.
• W29084826 modified "2023-10-15" @default.
• W29084826 title "Heat acclimation and cross-tolerance against novel stressors: genomic–physiological linkage" @default.
• W29084826 cites W1505839774 @default.
• W29084826 cites W1675038283 @default.
• W29084826 cites W1867805625 @default.
• W29084826 cites W187486356 @default.
• W29084826 cites W1965468893 @default.
• W29084826 cites W1966123292 @default.
• W29084826 cites W1966327498 @default.
• W29084826 cites W1968998324 @default.
• W29084826 cites W1970340840 @default.
• W29084826 cites W1977409271 @default.
• W29084826 cites W1981170407 @default.
• W29084826 cites W1984511554 @default.
• W29084826 cites W1986613106 @default.
• W29084826 cites W1990530423 @default.
• W29084826 cites W1991857152 @default.
• W29084826 cites W1992378167 @default.
• W29084826 cites W2002687832 @default.
• W29084826 cites W2003189015 @default.
• W29084826 cites W2003666655 @default.
• W29084826 cites W2005459650 @default.
• W29084826 cites W2008297208 @default.
• W29084826 cites W2010184205 @default.
• W29084826 cites W2013869842 @default.
• W29084826 cites W2018039414 @default.
• W29084826 cites W2018952643 @default.
• W29084826 cites W2021261012 @default.
• W29084826 cites W2024298422 @default.
• W29084826 cites W2026313838 @default.
• W29084826 cites W2029545663 @default.
• W29084826 cites W2030358362 @default.
• W29084826 cites W2030634993 @default.
• W29084826 cites W2030640103 @default.
• W29084826 cites W2031446345 @default.
• W29084826 cites W2031525343 @default.
• W29084826 cites W2032034864 @default.
• W29084826 cites W2042592058 @default.
• W29084826 cites W2047958850 @default.
• W29084826 cites W2054270907 @default.
• W29084826 cites W2061419177 @default.
• W29084826 cites W2070692593 @default.
• W29084826 cites W2078916626 @default.
• W29084826 cites W2083077388 @default.
• W29084826 cites W2086560181 @default.
• W29084826 cites W2093876462 @default.
• W29084826 cites W2097349578 @default.
• W29084826 cites W2099208314 @default.
• W29084826 cites W2100193366 @default.
• W29084826 cites W2104950980 @default.
• W29084826 cites W2105876548 @default.
• W29084826 cites W2105937761 @default.
• W29084826 cites W2116412161 @default.
• W29084826 cites W2120922349 @default.
• W29084826 cites W2120961294 @default.
• W29084826 cites W2122111818 @default.
• W29084826 cites W2122407910 @default.
• W29084826 cites W2129932871 @default.
• W29084826 cites W2135608921 @default.
• W29084826 cites W2137417976 @default.
• W29084826 cites W2137683543 @default.
• W29084826 cites W2143711952 @default.
• W29084826 cites W2145774658 @default.
• W29084826 cites W2146902247 @default.
• W29084826 cites W2151625241 @default.
• W29084826 cites W2152823402 @default.
• W29084826 cites W2171417754 @default.
• W29084826 cites W2174345978 @default.
• W29084826 cites W2174431287 @default.
• W29084826 cites W2179144694 @default.
• W29084826 cites W2179556324 @default.
• W29084826 cites W2179802238 @default.
• W29084826 cites W2193495273 @default.
• W29084826 cites W2202476213 @default.
• W29084826 cites W2203019670 @default.
• W29084826 cites W2216201770 @default.
• W29084826 cites W2261166570 @default.
• W29084826 cites W2263360945 @default.
• W29084826 cites W2286987267 @default.
• W29084826 cites W2319927000 @default.
• W29084826 cites W2417546929 @default.
• W29084826 doi "https://doi.org/10.1016/s0079-6123(06)62018-9" @default.
• W29084826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17645928" @default.
• W29084826 hasPublicationYear "2007" @default.
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