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• W2908565596 abstract "Objective: To evaluate the diagnostic value of the endoscopic biopsy operation to the lesions of the skull base in the patients with nasopharyngealcarcinoma after radiotherapy. Methods: From February 2006 to February 2010, 84 patients with nasopharyngeal carcinoma suffered from the lesions of the skull base after radiotherapy were included in this study. The relationship between the pathologic results of endoscopic biopsies from the skull base and the imaging results by Magnetic Resonance Imaging(MRI) was compared and discussed. The relationship between the pathologic results and more than 2-years' follow-up was also investigated. Results: There were 71 cases with clivus, 5 cases with pterygopalatine fossa and infratemporal fossa, 4 cases with parapharyngeal space, and 4 cases with cavernous sinus. The pathologic results of endoscopic biopsies indicated that 35 cases with recurrence including 30 case with poorly differentiated squamous cell carcinomas, 5 cases with cancer nests, 49 cases with non-tumor. Chi-square test showed that there was close relationship between MRI and pathologic results (P<0.05). In the patients followed up over 2 years, the pathologic results showed 28 cases with recurrence, 48 cases with non-tumor. MRI showed 36 cases with recurrence, 40 cases with non-tumor. But during follow-up, 30 cases were proved to be recurrent and 46 cases had non-tumor. However, Chi-square test showed that there was no statistically significance between the pathological results and follow-up(P=0.62). The sensitivity, specificity and diagnostic accuracy of the endoscopic diagnosis were 90.0%, 97.8% and 95.0%. Chi-square test also showed that there was no statistically significance between MRI and follow-up (P=0.24). The sensitivity, specificity and diagnostic accuracy of MRI were 80.0%, 73.9% and 76.0%. Conclusions: The endoscopic method is a specific, sensitive, safe, effective and minimally invasive in diagnosis of lesions of the skull base in postradiotherapeutic patients with nasopharyngeal carcinoma.目的： 探讨鼻内镜下鼻咽颅底活检术在鼻咽癌放疗后鼻咽颅底病变诊断中的价值。 方法： 回顾性分析2006年2月至2010年2月间鼻咽癌放疗后鼻咽颅底病变患者84例，将内镜下鼻咽颅底活检术的病理检查结果分别与磁共振成像(MRI)诊断、随访(≥2年)结果进行比较，评价内镜下鼻咽颅底活检术的诊断价值。 结果： MRI显示，斜坡区病变71例，翼腭窝和颞下窝病变5例，咽旁间隙病变4例，海绵窦病变4例。内镜下鼻咽颅底活检术病理诊断肿瘤复发35例，其中低分化鳞癌30例，癌巢5例；非肿瘤病变49例。内镜下鼻咽颅底活检术病理诊断与MRI诊断结果有关(P<0.05)。在随访≥2年的76例患者中，内镜下鼻咽颅底活检术病理诊断肿瘤复发28例，非肿瘤病变48例。MRI诊断肿瘤复发36例，非肿瘤病变40例。随访证实肿瘤复发30例，非肿瘤病变46例。内镜下鼻咽颅底活检术病理诊断结果与随访结果比较，差异无统计学意义(P＝0.62)。MRI诊断结果与随访结果比较，差异无统计学意义(P＝0.24)。鼻内镜下鼻咽颅底活检术病理诊断鼻咽癌放疗后鼻咽颅底病变的敏感度、特异度和正确率分别为90.0%、97.8%和95.0%。MRI诊断鼻咽癌放疗后鼻咽颅底病变的敏感度、特异度和正确率分别为80.0%、73.9%和76.0%。 结论： 内镜下鼻咽颅底病变活检术诊断鼻咽癌放疗后鼻咽颅底病变的特异度和敏感度高，且安全、有效，是鉴别鼻咽癌放疗后鼻咽颅底病变的有效手段。." @default.
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• W2908565596 date "2017-05-23" @default.
• W2908565596 modified "2023-09-27" @default.
• W2908565596 title "[Value of the endoscopic diagnosis on the lesions of the skull base in postradiotherapeutic patients with nasopharyngeal carcinoma]." @default.
• W2908565596 doi "https://doi.org/10.3760/cma.j.issn.0253-3766.2017.05.013" @default.
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