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- W2908633943 endingPage "559" @default.
- W2908633943 startingPage "549" @default.
- W2908633943 abstract "Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tat-interactive protein by multiple corresponding domains of DNA and H3 to maintain DNA methylation and histone modifications. Overexpression of UHRF1 has been found as a potential biomarker in various cancers resulting in either DNA hypermethylation or global DNA hypo-methylation, which participates in the occurrence, progression, and invasion of cancer. The role of UHRF1 in the reciprocal interaction between DNA methylation and histone modifications, the dynamic structural transformation of UHRF1 protein within epigenetic code replication machinery in epigenetic regulations, as well as modifications during cell cycle and chemotherapy targeting UHRF1 are evaluated in this study." @default.
- W2908633943 created "2019-01-25" @default.
- W2908633943 creator A5000095164 @default.
- W2908633943 creator A5005647300 @default.
- W2908633943 creator A5008234343 @default.
- W2908633943 creator A5033766542 @default.
- W2908633943 creator A5040013548 @default.
- W2908633943 creator A5040240218 @default.
- W2908633943 date "2019-01-01" @default.
- W2908633943 modified "2023-10-16" @default.
- W2908633943 title "Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies" @default.
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