FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2908655339> ?p ?o ?g. }

• W2908655339 abstract "Background There is international consensus around a core set of variables (cSLE-CRVs) to assess response to therapy with childhood-onset systemic lupus erythematosus (cSLE) [global assessment of patient well-being (Patient-global), physician assessment of cSLE activity (MD-global), disease activity index score, urine protein to creatinine ratio (PCR), Child Health Questionnaire physical function summary score (CHQ-Phs)]. Percentage changes of these cSLE-CRVs are used in the Provisional PRINTO-ACR- EULAR Criteria of Response to Therapy of cSLE (PCI). In a small dataset, we have previously shown that the PCI and the Systemic Lupus Responder Index only have fair accuracy in detecting cSLE improvement. The Objective of this research was to 1) validate the PCI and 2) develop for Children an Index of Lupus Improvement (CHILI) as a tool to measure response to therapy, with focus on clinically relevant improvement (CRIcSLE). Methods Pediatric subspecialists (n=213) in treating cSLE were invited to define CRIcSLE and rate a total of 433 unique patient profiles for the presence/absence of CRIcSLE and various levels of improvement. Patient profiles included the cSLE-CRVs and routine laboratory tests at a baseline and follow-up time-point. To measure CRIcSLE we tested the PCI, and developed the candidate CHILI criteria that considered a) absolute and b) percentage changes of the cSLE-CRVs (baseline vs follow-up) in a trainings-dataset and initially validated these criteria in the validation-dataset. Criteria accuracy was assessed by kappa statistics (PCI) and the area under the ROC curve (AUC; range: 0–1)], respectively. Results During an international consensus conference agreement on a definition of CRIcSLE was achieved. Response rate to patient profile ratings was 91% (194/214). The PIC had no more than fair accuracy (kappa 0.92, sensitivity: >93.1%; specificity: >73.4%), respectively. Conclusions The CHILI is a new highly accurate index to capture improvement in the overall course of cSLE. This index is also useful to categorize the degree of cSLE response to therapy. Acknowledgements For the Pediatric Rheumatology International Trial Network and the Pediatric Rheumatology Collaborative Study Group; the study is supported by NIH grants 5U01-AR51868, P30-AR AR47363 and 2UL1RR026314 and the PRCSG and PRINTO Coordinating Centers. This study is also supported by grants from Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP 2015/03756–4 to CAS), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq 303422/2015–7 to CAS) and by Nucleo de Apoio a Pesquisa ‘Saude da Crianca e do Adolescente’ da USP (NAP-CriAd) to CAS." @default.
• W2908655339 created "2019-01-25" @default.
• W2908655339 creator A5015854049 @default.
• W2908655339 creator A5015977988 @default.
• W2908655339 creator A5021386589 @default.
• W2908655339 creator A5029874460 @default.
• W2908655339 creator A5030180190 @default.
• W2908655339 creator A5030955894 @default.
• W2908655339 creator A5032187388 @default.
• W2908655339 creator A5035148024 @default.
• W2908655339 creator A5036519472 @default.
• W2908655339 creator A5038521422 @default.
• W2908655339 creator A5041150242 @default.
• W2908655339 creator A5041204910 @default.
• W2908655339 creator A5042287653 @default.
• W2908655339 creator A5056739139 @default.
• W2908655339 creator A5057371868 @default.
• W2908655339 creator A5078514598 @default.
• W2908655339 creator A5080140512 @default.
• W2908655339 creator A5088481433 @default.
• W2908655339 date "2018-08-01" @default.
• W2908655339 modified "2023-09-30" @default.
• W2908655339 title "CS-10 Criteria for clinically relevant improvement in children & adolescents with childhood-onset systemic lupus erythematosus" @default.
• W2908655339 doi "https://doi.org/10.1136/lupus-2018-lsm.45" @default.
• W2908655339 hasPublicationYear "2018" @default.
• W2908655339 type Work @default.
• W2908655339 sameAs 2908655339 @default.
• W2908655339 citedByCount "0" @default.
• W2908655339 crossrefType "proceedings-article" @default.
• W2908655339 hasAuthorship W2908655339A5015854049 @default.
• W2908655339 hasAuthorship W2908655339A5015977988 @default.
• W2908655339 hasAuthorship W2908655339A5021386589 @default.
• W2908655339 hasAuthorship W2908655339A5029874460 @default.
• W2908655339 hasAuthorship W2908655339A5030180190 @default.
• W2908655339 hasAuthorship W2908655339A5030955894 @default.
• W2908655339 hasAuthorship W2908655339A5032187388 @default.
• W2908655339 hasAuthorship W2908655339A5035148024 @default.
• W2908655339 hasAuthorship W2908655339A5036519472 @default.
• W2908655339 hasAuthorship W2908655339A5038521422 @default.
• W2908655339 hasAuthorship W2908655339A5041150242 @default.
• W2908655339 hasAuthorship W2908655339A5041204910 @default.
• W2908655339 hasAuthorship W2908655339A5042287653 @default.
• W2908655339 hasAuthorship W2908655339A5056739139 @default.
• W2908655339 hasAuthorship W2908655339A5057371868 @default.
• W2908655339 hasAuthorship W2908655339A5078514598 @default.
• W2908655339 hasAuthorship W2908655339A5080140512 @default.
• W2908655339 hasAuthorship W2908655339A5088481433 @default.
• W2908655339 hasBestOaLocation W29086553391 @default.
• W2908655339 hasConcept C126322002 @default.
• W2908655339 hasConcept C1862650 @default.
• W2908655339 hasConcept C2776912625 @default.
• W2908655339 hasConcept C2779134260 @default.
• W2908655339 hasConcept C45393284 @default.
• W2908655339 hasConcept C500558357 @default.
• W2908655339 hasConcept C71924100 @default.
• W2908655339 hasConceptScore W2908655339C126322002 @default.
• W2908655339 hasConceptScore W2908655339C1862650 @default.
• W2908655339 hasConceptScore W2908655339C2776912625 @default.
• W2908655339 hasConceptScore W2908655339C2779134260 @default.
• W2908655339 hasConceptScore W2908655339C45393284 @default.
• W2908655339 hasConceptScore W2908655339C500558357 @default.
• W2908655339 hasConceptScore W2908655339C71924100 @default.
• W2908655339 hasLocation W29086553391 @default.
• W2908655339 hasOpenAccess W2908655339 @default.
• W2908655339 hasPrimaryLocation W29086553391 @default.
• W2908655339 hasRelatedWork W1969924141 @default.
• W2908655339 hasRelatedWork W2078686066 @default.
• W2908655339 hasRelatedWork W2106654072 @default.
• W2908655339 hasRelatedWork W2129537748 @default.
• W2908655339 hasRelatedWork W2315167032 @default.
• W2908655339 hasRelatedWork W2318841710 @default.
• W2908655339 hasRelatedWork W2322000260 @default.
• W2908655339 hasRelatedWork W2325448917 @default.
• W2908655339 hasRelatedWork W2480429159 @default.
• W2908655339 hasRelatedWork W2555922206 @default.
• W2908655339 hasRelatedWork W2744646244 @default.
• W2908655339 hasRelatedWork W2755535356 @default.
• W2908655339 hasRelatedWork W2755931468 @default.
• W2908655339 hasRelatedWork W2794151501 @default.
• W2908655339 hasRelatedWork W2794259934 @default.
• W2908655339 hasRelatedWork W2904745077 @default.
• W2908655339 hasRelatedWork W2935755914 @default.
• W2908655339 hasRelatedWork W2947603510 @default.
• W2908655339 hasRelatedWork W3108496306 @default.
• W2908655339 hasRelatedWork W3213293838 @default.
• W2908655339 isParatext "false" @default.
• W2908655339 isRetracted "false" @default.
• W2908655339 magId "2908655339" @default.
• W2908655339 workType "article" @default.