Matches in SemOpenAlex for { <https://semopenalex.org/work/W2908667100> ?p ?o ?g. }
- W2908667100 endingPage "13" @default.
- W2908667100 startingPage "1" @default.
- W2908667100 abstract "Nuclear receptors (NRs) are ligand-dependent transcription factors that regulate the transcription of target genes. Previous epidemiological and genetic studies have documented the association of NRs with the risk of inflammatory bowel disease (IBD). Although the mechanisms of action of NRs in IBD have not been fully established, accumulating evidence has demonstrated that NRs play complicated roles in regulating intestinal immunity, mucosal barriers, and intestinal flora. As one of the first-line medications for the treatment of IBD, 5-aminosalicylic acid (5-ASA) activates peroxisome proliferator-activated receptor gamma (PPAR γ ) to attenuate colitis. The protective roles of rifaximin and rifampicin partly depend on promoting pregnane X receptor (PXR) expression. The aims of this review are to discuss the roles of several important NRs, such as PPAR γ , PXR, vitamin D receptor (VDR), farnesoid X receptor (FXR), and RAR-related orphan receptor gammat (ROR γ t), in the pathogenesis of IBD and management strategies based on targeting these receptors." @default.
- W2908667100 created "2019-01-25" @default.
- W2908667100 creator A5024756645 @default.
- W2908667100 creator A5030670360 @default.
- W2908667100 creator A5080885482 @default.
- W2908667100 creator A5088654813 @default.
- W2908667100 date "2019-01-21" @default.
- W2908667100 modified "2023-09-26" @default.
- W2908667100 title "Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease" @default.
- W2908667100 cites W1417251146 @default.
- W2908667100 cites W1490272647 @default.
- W2908667100 cites W1544124240 @default.
- W2908667100 cites W1552925034 @default.
- W2908667100 cites W1559792721 @default.
- W2908667100 cites W1597214954 @default.
- W2908667100 cites W1655905490 @default.
- W2908667100 cites W1915935221 @default.
- W2908667100 cites W1919133853 @default.
- W2908667100 cites W1955924422 @default.
- W2908667100 cites W1962046992 @default.
- W2908667100 cites W1966584131 @default.
- W2908667100 cites W1967319082 @default.
- W2908667100 cites W1968362155 @default.
- W2908667100 cites W1972815843 @default.
- W2908667100 cites W1973767685 @default.
- W2908667100 cites W1977415187 @default.
- W2908667100 cites W1992035731 @default.
- W2908667100 cites W1992325707 @default.
- W2908667100 cites W1993701704 @default.
- W2908667100 cites W1994882377 @default.
- W2908667100 cites W1998658578 @default.
- W2908667100 cites W2003115027 @default.
- W2908667100 cites W2005322337 @default.
- W2908667100 cites W2010459511 @default.
- W2908667100 cites W2012065014 @default.
- W2908667100 cites W2013145525 @default.
- W2908667100 cites W2013692871 @default.
- W2908667100 cites W2014425464 @default.
- W2908667100 cites W2015922970 @default.
- W2908667100 cites W2017435559 @default.
- W2908667100 cites W2020467083 @default.
- W2908667100 cites W2021264322 @default.
- W2908667100 cites W2022186535 @default.
- W2908667100 cites W2024385931 @default.
- W2908667100 cites W2024490058 @default.
- W2908667100 cites W2029107507 @default.
- W2908667100 cites W2031147980 @default.
- W2908667100 cites W2032025006 @default.
- W2908667100 cites W2038177382 @default.
- W2908667100 cites W2038411989 @default.
- W2908667100 cites W2038621270 @default.
- W2908667100 cites W2044198438 @default.
- W2908667100 cites W2047852384 @default.
- W2908667100 cites W2049999589 @default.
- W2908667100 cites W2050092688 @default.
- W2908667100 cites W2051287129 @default.
- W2908667100 cites W2052390133 @default.
- W2908667100 cites W2054265413 @default.
- W2908667100 cites W2054619593 @default.
- W2908667100 cites W2063418390 @default.
- W2908667100 cites W2065760784 @default.
- W2908667100 cites W2067961925 @default.
- W2908667100 cites W2072822958 @default.
- W2908667100 cites W2078754045 @default.
- W2908667100 cites W2079307477 @default.
- W2908667100 cites W2083373216 @default.
- W2908667100 cites W2083668079 @default.
- W2908667100 cites W2084412222 @default.
- W2908667100 cites W2084765237 @default.
- W2908667100 cites W2088284776 @default.
- W2908667100 cites W2089815887 @default.
- W2908667100 cites W2097136349 @default.
- W2908667100 cites W2098568145 @default.
- W2908667100 cites W2101781154 @default.
- W2908667100 cites W2102490761 @default.
- W2908667100 cites W2102567329 @default.
- W2908667100 cites W2103066561 @default.
- W2908667100 cites W2105854609 @default.
- W2908667100 cites W2110874171 @default.
- W2908667100 cites W2111567870 @default.
- W2908667100 cites W2113025000 @default.
- W2908667100 cites W2113427789 @default.
- W2908667100 cites W2116482730 @default.
- W2908667100 cites W2118910939 @default.
- W2908667100 cites W2118913132 @default.
- W2908667100 cites W2119543164 @default.
- W2908667100 cites W2120166249 @default.
- W2908667100 cites W2120356061 @default.
- W2908667100 cites W2121484716 @default.
- W2908667100 cites W2125283861 @default.
- W2908667100 cites W2125524268 @default.
- W2908667100 cites W2127633278 @default.
- W2908667100 cites W2128233861 @default.
- W2908667100 cites W2132784721 @default.
- W2908667100 cites W2133431701 @default.
- W2908667100 cites W2133465579 @default.
- W2908667100 cites W2134059673 @default.
- W2908667100 cites W2134624067 @default.