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• W2908782159 startingPage "14154" @default.
• W2908782159 abstract "Long noncoding RNA UCA1 has exerted a significant effect in cardiovascular disease. The biological role of UCA1 in atherosclerosis is unclear. Our study was to identify the potential mechanisms in the progression of atherosclerosis. Here, we observed that ox-LDL increased UCA1 expression greatly in THP-1 cells. Knockdown of UCA1 greatly inhibited CD36 expression, a crucial biomarker in atherosclerosis. Meanwhile, 20 μg/ml ox-LDL induced foam cell formation, which can be reversed by downregulation of UCA1. In addition, TC and TG levels induced by ox-LDL was rescued by UCA1 small interfering RNA. Accumulating studies have indicated that oxidative stress contributes to atherosclerosis progression. Here, we also found that reactive oxygen species, MDA, and THP-1 cell apoptosis were restrained by decreased of UCA1 with an increase of the superoxide dismutase activity. Moreover, miR-206 was predicted as a target of UCA1 and knockdown of UCA1 was able to repress miR-206 expression. Furthermore, overexpression of miR-206 inhibited oxidative stress process and it was reversed by UCA1 upregulation in vitro. In conclusion, we indicated that UCA1 sponged miR-206 to exacerbate atherosclerosis events induced by ox-LDL in THP-1 cells." @default.
• W2908782159 created "2019-01-25" @default.
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• W2908782159 date "2019-01-11" @default.
• W2908782159 modified "2023-10-18" @default.
• W2908782159 title "LncRNA UCA1 sponges miR‐206 to exacerbate oxidative stress and apoptosis induced by ox‐LDL in human macrophages" @default.
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• W2908782159 doi "https://doi.org/10.1002/jcp.28109" @default.
• W2908782159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30633352" @default.
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