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• W2908788147 abstract "The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain largely unknown. Here, we profile the DNA methylation landscape of single CTCs and CTC clusters from breast cancer patients and mouse models on a genome-wide scale. We find that binding sites for stemness- and proliferation-associated transcription factors are specifically hypomethylated in CTC clusters, including binding sites for OCT4, NANOG, SOX2, and SIN3A, paralleling embryonic stem cell biology. Among 2,486 FDA-approved compounds, we identify Na+/K+ ATPase inhibitors that enable the dissociation of CTC clusters into single cells, leading to DNA methylation remodeling at critical sites and metastasis suppression. Thus, our results link CTC clustering to specific changes in DNA methylation that promote stemness and metastasis and point to cluster-targeting compounds to suppress the spread of cancer." @default.
• W2908788147 created "2019-01-25" @default.
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• W2908788147 date "2019-01-01" @default.
• W2908788147 modified "2023-10-13" @default.
• W2908788147 title "Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding" @default.
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• W2908788147 doi "https://doi.org/10.1016/j.cell.2018.11.046" @default.
• W2908788147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6363966" @default.
• W2908788147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30633912" @default.
• W2908788147 hasPublicationYear "2019" @default.
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