Matches in SemOpenAlex for { <https://semopenalex.org/work/W2908871841> ?p ?o ?g. }
- W2908871841 abstract "Cancer stem-like cells (CSCs) have been shown to initiate tumorigenesis and cancer metastasis in many cancer types. Although identification of CSCs through specific marker expression helps define the CSC compartment, it does not directly provide information on how or why this cancer cell subpopulation is more metastatic or tumorigenic. In this study, the functional and biophysical characteristics of aggressive and lethal inflammatory breast cancer (IBC) CSCs at the single-cell level are comprehensively profiled using multiple microengineered tools. Distinct functional (cell migration, growth, adhesion, invasion and self-renewal) and biophysical (cell deformability, adhesion strength and contractility) properties of ALDH+ SUM149 IBC CSCs are found as compared to their ALDH- non-CSC counterpart, providing biophysical insights into why CSCs has an enhanced propensity to metastasize. It is further shown that the cellular biophysical phenotype can predict and determine IBC cells' tumorigenic ability. SUM149 and SUM159 IBC cells selected and modulated through biophysical attributes-adhesion and stiffness-show characteristics of CSCs in vitro and enhance tumorigenicity in in vivo murine models of primary tumor growth. Overall, the multiparametric cellular biophysical phenotyping and modulation of IBC CSCs yields a new understanding of IBC's metastatic properties and how they might develop and be targeted for therapeutic interventions." @default.
- W2908871841 created "2019-01-25" @default.
- W2908871841 creator A5001811088 @default.
- W2908871841 creator A5010295861 @default.
- W2908871841 creator A5021469738 @default.
- W2908871841 creator A5022288270 @default.
- W2908871841 creator A5027649222 @default.
- W2908871841 creator A5040287074 @default.
- W2908871841 creator A5058078911 @default.
- W2908871841 creator A5063240874 @default.
- W2908871841 creator A5066227522 @default.
- W2908871841 creator A5071284069 @default.
- W2908871841 creator A5071608210 @default.
- W2908871841 creator A5081316996 @default.
- W2908871841 date "2019-01-11" @default.
- W2908871841 modified "2023-10-12" @default.
- W2908871841 title "Biophysical Phenotyping and Modulation of ALDH+ Inflammatory Breast Cancer Stem‐Like Cells" @default.
- W2908871841 cites W1848082114 @default.
- W2908871841 cites W1958877028 @default.
- W2908871841 cites W1967245224 @default.
- W2908871841 cites W1967265143 @default.
- W2908871841 cites W1968903390 @default.
- W2908871841 cites W1969889648 @default.
- W2908871841 cites W1973089587 @default.
- W2908871841 cites W1975553175 @default.
- W2908871841 cites W1990099538 @default.
- W2908871841 cites W1992449688 @default.
- W2908871841 cites W1992905672 @default.
- W2908871841 cites W1996152000 @default.
- W2908871841 cites W1996757213 @default.
- W2908871841 cites W1997847812 @default.
- W2908871841 cites W2001765718 @default.
- W2908871841 cites W2014464681 @default.
- W2908871841 cites W2017975901 @default.
- W2908871841 cites W2023316892 @default.
- W2908871841 cites W2023427658 @default.
- W2908871841 cites W2029154157 @default.
- W2908871841 cites W2029231546 @default.
- W2908871841 cites W2039411165 @default.
- W2908871841 cites W2040937654 @default.
- W2908871841 cites W2047291014 @default.
- W2908871841 cites W2049623935 @default.
- W2908871841 cites W2049854165 @default.
- W2908871841 cites W2060932651 @default.
- W2908871841 cites W2069598084 @default.
- W2908871841 cites W2069831652 @default.
- W2908871841 cites W2076446882 @default.
- W2908871841 cites W2081447858 @default.
- W2908871841 cites W2082057023 @default.
- W2908871841 cites W2084488214 @default.
- W2908871841 cites W2085950211 @default.
- W2908871841 cites W2086277592 @default.
- W2908871841 cites W2086828029 @default.
- W2908871841 cites W2087850490 @default.
- W2908871841 cites W2093126111 @default.
- W2908871841 cites W2095192232 @default.
- W2908871841 cites W2098400442 @default.
- W2908871841 cites W2099052265 @default.
- W2908871841 cites W2100303404 @default.
- W2908871841 cites W2101962857 @default.
- W2908871841 cites W2102085111 @default.
- W2908871841 cites W2103883318 @default.
- W2908871841 cites W2105504936 @default.
- W2908871841 cites W2106639911 @default.
- W2908871841 cites W2110148884 @default.
- W2908871841 cites W2116413963 @default.
- W2908871841 cites W2129102832 @default.
- W2908871841 cites W2129162784 @default.
- W2908871841 cites W2129375080 @default.
- W2908871841 cites W2129449151 @default.
- W2908871841 cites W2130841925 @default.
- W2908871841 cites W2131170195 @default.
- W2908871841 cites W2136456223 @default.
- W2908871841 cites W2142291307 @default.
- W2908871841 cites W2143995836 @default.
- W2908871841 cites W2144142508 @default.
- W2908871841 cites W2148528535 @default.
- W2908871841 cites W2151879335 @default.
- W2908871841 cites W2151948621 @default.
- W2908871841 cites W2153382986 @default.
- W2908871841 cites W2154061152 @default.
- W2908871841 cites W2157807617 @default.
- W2908871841 cites W2157840058 @default.
- W2908871841 cites W2158627893 @default.
- W2908871841 cites W2159835158 @default.
- W2908871841 cites W2165286055 @default.
- W2908871841 cites W2165428601 @default.
- W2908871841 cites W2167650288 @default.
- W2908871841 cites W2293333424 @default.
- W2908871841 cites W2337203915 @default.
- W2908871841 cites W2426003472 @default.
- W2908871841 cites W2476542314 @default.
- W2908871841 cites W2488811617 @default.
- W2908871841 cites W2804310577 @default.
- W2908871841 cites W57672764 @default.
- W2908871841 doi "https://doi.org/10.1002/smll.201802891" @default.
- W2908871841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6486377" @default.
- W2908871841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30632269" @default.
- W2908871841 hasPublicationYear "2019" @default.
- W2908871841 type Work @default.