Matches in SemOpenAlex for { <https://semopenalex.org/work/W2908890384> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2908890384 abstract "Background Several factors increasing the risk of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis have been reported. These include pulmonary and cardiovascular lesions, PR3-ANCA-positivity in patients with granulomatosis with polyangiitis, and persistent ANCA-positivity or an increase in the titer of such antibodies. Objectives We aimed to identify potentially novel factors predicting relapse in patients with ANCA-associated vasculitis. Methods We reviewed data on 73 patients (61 with microscopic polyangiitis [MPA], 12 with granulomatosis with polyangiitis [GPA]; 46 females) treated in our centre from 1998 to 2017 for whom medical histories were available. All achieved at least one remission after induction therapy. Relapse was defined as novel organ involvement or a need for therapy intensification. Follow-up continued to the first relapse or for as long as possible if no relapse was noted. Results The median age at disease onset (interquartile range) was 74 years (range: 67–80 years). The relapse rate was 42.5% (MPA 41%, GPA 50%), thus not significantly different between the two groups (p=0.75). The median follow-up duration was 23 months (range: 11–65 months) and the median time to relapse was 18 months (range: 10.5–54 months). Although pulmonary and cardiac lesions reportedly increase the relapse rate, neither contributed significantly to the rate in this study. Furthermore, ANCA-positivity after remission and increases in ANCA levels prior to relapse did not significantly increase the relapse risk. In terms of medical histories recorded at the time of first onset of disease, the frequency of diabetes, dyslipidemia, coronary artery disease, and cerebral infarction did not differ significantly between patients who did and did not relapse. However, in MPA patients, a history of hypertension was significantly less in those who relapsed (p=0.01). In a multiple logistic regression analysis adjusted for sex and age, history of hypertension was a significant predictor of fewer relapse (odds ratio: 0.23; 95% confidence interval 0.07–0.69, p=0.009). Conclusions In addition to known factors, a history of hypertension recorded at the time of disease onset may predict fewer MPA relapse. References [1] Kyndt X, et al. Am J Med. 1999May;106(5):527–33. [2] Hogan SL, et al. Ann Intern Med. 2005Nov 1;143(9):621–31. Disclosure of Interest None declared" @default.
- W2908890384 created "2019-01-25" @default.
- W2908890384 creator A5005548789 @default.
- W2908890384 creator A5011728066 @default.
- W2908890384 creator A5019636793 @default.
- W2908890384 creator A5028422940 @default.
- W2908890384 creator A5034445996 @default.
- W2908890384 creator A5034468685 @default.
- W2908890384 creator A5036238567 @default.
- W2908890384 creator A5057655144 @default.
- W2908890384 date "2018-06-01" @default.
- W2908890384 modified "2023-09-27" @default.
- W2908890384 title "AB0682 Risk factors associated with relapse of anti-neutrophil cytoplasmic antibody-associated vasculitis" @default.
- W2908890384 doi "https://doi.org/10.1136/annrheumdis-2018-eular.5468" @default.
- W2908890384 hasPublicationYear "2018" @default.
- W2908890384 type Work @default.
- W2908890384 sameAs 2908890384 @default.
- W2908890384 citedByCount "0" @default.
- W2908890384 crossrefType "proceedings-article" @default.
- W2908890384 hasAuthorship W2908890384A5005548789 @default.
- W2908890384 hasAuthorship W2908890384A5011728066 @default.
- W2908890384 hasAuthorship W2908890384A5019636793 @default.
- W2908890384 hasAuthorship W2908890384A5028422940 @default.
- W2908890384 hasAuthorship W2908890384A5034445996 @default.
- W2908890384 hasAuthorship W2908890384A5034468685 @default.
- W2908890384 hasAuthorship W2908890384A5036238567 @default.
- W2908890384 hasAuthorship W2908890384A5057655144 @default.
- W2908890384 hasBestOaLocation W29088903841 @default.
- W2908890384 hasConcept C119060515 @default.
- W2908890384 hasConcept C126322002 @default.
- W2908890384 hasConcept C134018914 @default.
- W2908890384 hasConcept C203014093 @default.
- W2908890384 hasConcept C24040308 @default.
- W2908890384 hasConcept C2776015282 @default.
- W2908890384 hasConcept C2778096610 @default.
- W2908890384 hasConcept C2778910314 @default.
- W2908890384 hasConcept C2779134260 @default.
- W2908890384 hasConcept C2781229154 @default.
- W2908890384 hasConcept C555293320 @default.
- W2908890384 hasConcept C71924100 @default.
- W2908890384 hasConcept C90924648 @default.
- W2908890384 hasConceptScore W2908890384C119060515 @default.
- W2908890384 hasConceptScore W2908890384C126322002 @default.
- W2908890384 hasConceptScore W2908890384C134018914 @default.
- W2908890384 hasConceptScore W2908890384C203014093 @default.
- W2908890384 hasConceptScore W2908890384C24040308 @default.
- W2908890384 hasConceptScore W2908890384C2776015282 @default.
- W2908890384 hasConceptScore W2908890384C2778096610 @default.
- W2908890384 hasConceptScore W2908890384C2778910314 @default.
- W2908890384 hasConceptScore W2908890384C2779134260 @default.
- W2908890384 hasConceptScore W2908890384C2781229154 @default.
- W2908890384 hasConceptScore W2908890384C555293320 @default.
- W2908890384 hasConceptScore W2908890384C71924100 @default.
- W2908890384 hasConceptScore W2908890384C90924648 @default.
- W2908890384 hasLocation W29088903841 @default.
- W2908890384 hasOpenAccess W2908890384 @default.
- W2908890384 hasPrimaryLocation W29088903841 @default.
- W2908890384 hasRelatedWork W1822283139 @default.
- W2908890384 hasRelatedWork W2000378313 @default.
- W2908890384 hasRelatedWork W2080567030 @default.
- W2908890384 hasRelatedWork W2123092609 @default.
- W2908890384 hasRelatedWork W2162416852 @default.
- W2908890384 hasRelatedWork W2326318909 @default.
- W2908890384 hasRelatedWork W2331666083 @default.
- W2908890384 hasRelatedWork W2337647990 @default.
- W2908890384 hasRelatedWork W2339346940 @default.
- W2908890384 hasRelatedWork W2592376209 @default.
- W2908890384 hasRelatedWork W2807824120 @default.
- W2908890384 hasRelatedWork W2950895157 @default.
- W2908890384 hasRelatedWork W3017992625 @default.
- W2908890384 hasRelatedWork W3026834220 @default.
- W2908890384 hasRelatedWork W3034220447 @default.
- W2908890384 hasRelatedWork W3112246397 @default.
- W2908890384 hasRelatedWork W3128192703 @default.
- W2908890384 hasRelatedWork W3164815799 @default.
- W2908890384 hasRelatedWork W3186550057 @default.
- W2908890384 hasRelatedWork W3206125021 @default.
- W2908890384 isParatext "false" @default.
- W2908890384 isRetracted "false" @default.
- W2908890384 magId "2908890384" @default.
- W2908890384 workType "article" @default.