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- W2908892191 abstract "Allogeneic chimeric antigen receptor T (CAR T) cells can offer advantages over autologous T cell therapies, including the availability of “fit” cells for production, and elimination of risks associated with inadvertent transduction of leukemic blasts. However, allogeneic T cell therapies must address HLA barriers and conventionally rely on the availability of a suitable HLA‐matched donor if graft‐vs‐host‐disease and rejection effects are to be avoided. More recently, the incorporation of additional genome editing manipulations, to disrupt T cell receptor expression and address other critical pathways have been explored. Clinical trials are underway investigating non‐HLA matched T cells expressing anti‐CD19 CARs for the treatment of B cell acute lymphoblastic leukemia (B‐ALL) and anti‐CD123 CAR for acute myeloid leukemia (AML). Such approaches continue to be refined and improved to widen accessibility and reduce the cost of T cell therapies for a wider range of conditions." @default.
- W2908892191 created "2019-01-25" @default.
- W2908892191 creator A5044799435 @default.
- W2908892191 date "2019-02-01" @default.
- W2908892191 modified "2023-10-03" @default.
- W2908892191 title "Allogeneic CAR T cell therapies for leukemia" @default.
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- W2908892191 doi "https://doi.org/10.1002/ajh.25399" @default.
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