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• W2908920509 abstract "Event Abstract Back to Event Isolation of Scopoletin from Paederia foetida and its Antidiabetic Potential Using In silico Model Dai Chuan Tan1*, Ku Idayu Idris1, Nur Kartinee Kassim1*, Pei Cee Lim1, Intan Safinar Ismail1, Muhajir Hamid1 and Rou Chian Ng1 1 Putra Malaysia University, Malaysia Background Paederia foetida L. (Rubiaceae) is an edible plant widely distributed in India, Japan, Malaysia, and other Asian countries. This study investigates the enzyme inhibition and of P. foetida twig extracts obtained from two different locations namely Johor (PFJ) and Pahang (PFP) and its chemical constituents. Methods The isolation of phytoconstituents using column chromatography methods and in silico study of isolated compound with receptor (α-glucosidase and α-amylase) was carried out using molecular docking. Results The IC50 of α-glucosidase and α-amylase inhibition activity of the PFJ chloroform extract were 245.6 ± 0.01 and 9.595 ± 0.01 µg/mL, respectively. The IC50 of α-glucosidase and α-alpha amylase inhibition activity of PFP chloroform extract were 2457.2 ± 0.01 and 14.83 ± 0.05 µg/mL, respectively. Separation of PFP chloroform extract afforded ergost-5-en-3-ol (1), stigmasterol (2), γ-sitosterol (3) and scopoletin (4) meanwhile PFJ chloroform extract gave (2) and (4). Scopoletin was isolated for the first time from this species. In silico molecular interaction study between scopoletin and α-glucosidase and α-amylase showed that α-glucosidase-scopoletin inhibitor complex had better binding affinity with less energy value (-5.4 kcal/mol) than α-amylase-scopoletin inhibitor complex (-4.9 kcal/mol). Conclusion PFJ chloroform extract showed potent inhibitory activity toward α-glucosidase. The in silico assessment of scopoletin as antidiabetic agent indicated that α-glucosidase-scopoletin complex has good stability with binding affinity of -5.4 kcal/mol. P. foetida can be considered as potential resources for natural herbal antidiabetic drugs which can serve as alternative to synthetic oral hypoglycemic drugs with minimum side effects. Keywords: Paederia foetida, Scopoletin, alpha-Amylase, Alpha-glucosidase, molecular docking Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Oral Presentation Topic: Metabolic diseases Citation: Tan D, Idris K, Kassim N, Lim P, Ismail I, Hamid M and Ng R (2019). Isolation of Scopoletin from Paederia foetida and its Antidiabetic Potential Using In silico Model. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2019.63.00025 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 12 Nov 2018; Published Online: 17 Jan 2019. * Correspondence: Mr. Dai Chuan Tan, Putra Malaysia University, Seri Kembangan, Malaysia, dctan@chhs.edu.my Dr. Nur Kartinee Kassim, Putra Malaysia University, Seri Kembangan, Malaysia, kartinee@upm.edu.my Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Dai Chuan Tan Ku Idayu Idris Nur Kartinee Kassim Pei Cee Lim Intan Safinar Ismail Muhajir Hamid Rou Chian Ng Google Dai Chuan Tan Ku Idayu Idris Nur Kartinee Kassim Pei Cee Lim Intan Safinar Ismail Muhajir Hamid Rou Chian Ng Google Scholar Dai Chuan Tan Ku Idayu Idris Nur Kartinee Kassim Pei Cee Lim Intan Safinar Ismail Muhajir Hamid Rou Chian Ng PubMed Dai Chuan Tan Ku Idayu Idris Nur Kartinee Kassim Pei Cee Lim Intan Safinar Ismail Muhajir Hamid Rou Chian Ng Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2908920509 title "Isolation of Scopoletin from Paederia foetida and its Antidiabetic Potential Using In silico Model" @default.
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