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- W2908938827 abstract "CDK4/6 inhibitors are a new class of anticancer drugs used for the treatment of women with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy. Polypharmacy is a well-known problem in advanced cancer causing potential drug-drug interactions (DDIs), which, in turn, may limit the therapeutic value of CDK4/6 inhibitors. Therefore, understanding the mechanisms underlying potential DDIs in patients taking CDK4/6 inhibitors may be useful in decision-making processes and represent an important step towards treatment personalization. The present review is aimed at describing the potential DDIs that might occur in breast cancer patients receiving CDK4/6 inhibitors based on direct evidence from the literature and mechanistic considerations tailored on specific class of drugs used in combination." @default.
- W2908938827 created "2019-01-25" @default.
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- W2908938827 date "2019-03-01" @default.
- W2908938827 modified "2023-09-25" @default.
- W2908938827 title "Drug-drug interactions in breast cancer patients treated with CDK4/6 inhibitors" @default.
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- W2908938827 doi "https://doi.org/10.1016/j.ctrv.2019.01.006" @default.
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