FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2908939173> ?p ?o ?g. }

• W2908939173 endingPage "10" @default.
• W2908939173 startingPage "1" @default.
• W2908939173 abstract "Sucralose, one kind of sugar-free artificial sweeteners, is widely used as food and drinks additives. It is generally considered that sucralose is safe because majority of ingested sucralose is not metabolized and absorbed by human body. However, increasing evidence shows the negative effects of artificial sweeteners in perturbations of gut microbiota which plays an important role in a variety of processes related to host health such as immune system development. Specifically, sucralose uptake can alter the homeostasis of mouse gut microbiota, resulting in the significant changes of gut bacterial genera diversity, metabolic patterns, and fecal metabolite profiles as well as inducing host liver inflammation. Therefore, there is a need to study liver proteome changes which may be potentially affected by sucralose-induced dysbiosis. In this study, isobaric labeling-based quantitative proteomics was performed to reveal the liver functional proteome changes in male C57BL/6J mice with sucralose administration in drinking water for six-month period. The labeled tryptic peptides were off-line fractionated before LC-MS/MS analysis to improve proteome coverage detected. SIGNIFICANCE: We demonstrated the first quantitative proteomics for mice liver proteome to evaluate the effect of sucralose consumption. In total, >5700 protein groups were identified from 18 mouse liver tissues (9 from control group; 9 from sucralose-treated group), and 4327 protein groups were quantified in all samples without any missing values. Among them, 113 protein groups were identified with statistical significance (q value <0.05) as differentially expressed proteins. Bioinformatics analysis revealed the systematic dysregulations of protein metabolism after sucralose treatment. Importantly, our findings proposed that enhanced inflammation may be triggered by ribosomal inactivation in sucralose treated mice liver." @default.
• W2908939173 created "2019-01-25" @default.
• W2908939173 creator A5011203043 @default.
• W2908939173 creator A5015181517 @default.
• W2908939173 creator A5020085126 @default.
• W2908939173 creator A5021100880 @default.
• W2908939173 creator A5043964648 @default.
• W2908939173 creator A5073648522 @default.
• W2908939173 date "2019-03-01" @default.
• W2908939173 modified "2023-10-09" @default.
• W2908939173 title "Quantitative proteomics reveals systematic dysregulations of liver protein metabolism in sucralose-treated mice" @default.
• W2908939173 cites W1988146323 @default.
• W2908939173 cites W1989947363 @default.
• W2908939173 cites W2003351542 @default.
• W2908939173 cites W2009170813 @default.
• W2908939173 cites W2012490955 @default.
• W2908939173 cites W2019196704 @default.
• W2908939173 cites W2029330831 @default.
• W2908939173 cites W2031608580 @default.
• W2908939173 cites W2048280438 @default.
• W2908939173 cites W2056499061 @default.
• W2908939173 cites W2065191024 @default.
• W2908939173 cites W2071841602 @default.
• W2908939173 cites W2074246631 @default.
• W2908939173 cites W2084329579 @default.
• W2908939173 cites W2101938218 @default.
• W2908939173 cites W2107541885 @default.
• W2908939173 cites W2113570557 @default.
• W2908939173 cites W2131186249 @default.
• W2908939173 cites W2145613496 @default.
• W2908939173 cites W2149945060 @default.
• W2908939173 cites W2158217645 @default.
• W2908939173 cites W2167062509 @default.
• W2908939173 cites W2168223461 @default.
• W2908939173 cites W2168270559 @default.
• W2908939173 cites W2168672668 @default.
• W2908939173 cites W2170776626 @default.
• W2908939173 cites W2175136759 @default.
• W2908939173 cites W2212431290 @default.
• W2908939173 cites W2278988761 @default.
• W2908939173 cites W2288901288 @default.
• W2908939173 cites W2289692800 @default.
• W2908939173 cites W2436016506 @default.
• W2908939173 cites W2463195069 @default.
• W2908939173 cites W2537623931 @default.
• W2908939173 cites W2544360569 @default.
• W2908939173 cites W2556215787 @default.
• W2908939173 cites W2611502608 @default.
• W2908939173 cites W2617442709 @default.
• W2908939173 cites W2623259478 @default.
• W2908939173 cites W2623923045 @default.
• W2908939173 cites W2739328078 @default.
• W2908939173 cites W2761532420 @default.
• W2908939173 cites W2766458342 @default.
• W2908939173 cites W2778045389 @default.
• W2908939173 cites W2792896655 @default.
• W2908939173 doi "https://doi.org/10.1016/j.jprot.2019.01.011" @default.
• W2908939173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30660768" @default.
• W2908939173 hasPublicationYear "2019" @default.
• W2908939173 type Work @default.
• W2908939173 sameAs 2908939173 @default.
• W2908939173 citedByCount "19" @default.
• W2908939173 countsByYear W29089391732019 @default.
• W2908939173 countsByYear W29089391732020 @default.
• W2908939173 countsByYear W29089391732021 @default.
• W2908939173 countsByYear W29089391732022 @default.
• W2908939173 countsByYear W29089391732023 @default.
• W2908939173 crossrefType "journal-article" @default.
• W2908939173 hasAuthorship W2908939173A5011203043 @default.
• W2908939173 hasAuthorship W2908939173A5015181517 @default.
• W2908939173 hasAuthorship W2908939173A5020085126 @default.
• W2908939173 hasAuthorship W2908939173A5021100880 @default.
• W2908939173 hasAuthorship W2908939173A5043964648 @default.
• W2908939173 hasAuthorship W2908939173A5073648522 @default.
• W2908939173 hasConcept C104317684 @default.
• W2908939173 hasConcept C104397665 @default.
• W2908939173 hasConcept C135870905 @default.
• W2908939173 hasConcept C185592680 @default.
• W2908939173 hasConcept C203014093 @default.
• W2908939173 hasConcept C2776480571 @default.
• W2908939173 hasConcept C2777477808 @default.
• W2908939173 hasConcept C31903555 @default.
• W2908939173 hasConcept C46111723 @default.
• W2908939173 hasConcept C539455810 @default.
• W2908939173 hasConcept C55493867 @default.
• W2908939173 hasConcept C62231903 @default.
• W2908939173 hasConcept C73090800 @default.
• W2908939173 hasConcept C80311884 @default.
• W2908939173 hasConcept C86803240 @default.
• W2908939173 hasConcept C8891405 @default.
• W2908939173 hasConcept C89423630 @default.
• W2908939173 hasConceptScore W2908939173C104317684 @default.
• W2908939173 hasConceptScore W2908939173C104397665 @default.
• W2908939173 hasConceptScore W2908939173C135870905 @default.
• W2908939173 hasConceptScore W2908939173C185592680 @default.
• W2908939173 hasConceptScore W2908939173C203014093 @default.
• W2908939173 hasConceptScore W2908939173C2776480571 @default.
• W2908939173 hasConceptScore W2908939173C2777477808 @default.

• next