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• W2908940596 abstract "NMR relaxation dispersion methods provide a holistic way to observe microsecond time-scale protein backbone motion both in solution and in the solid state. Different nuclei (1H and 15N) and different relaxation dispersion techniques (Bloch–McConnell and near-rotary-resonance) give complementary information about the amplitudes and time scales of the conformational dynamics and provide comprehensive insights into the mechanistic details of the structural rearrangements. In this paper, we exemplify the benefits of the combination of various solution- and solid-state relaxation dispersion methods on a microcrystalline protein (α-spectrin SH3 domain), for which we are able to identify and model the functionally relevant conformational rearrangements around the ligand recognition loop occurring on multiple microsecond time scales. The observed loop motions suggest that the SH3 domain exists in a binding-competent conformation in dynamic equilibrium with a sterically impaired ground-state conformation both in solution and in crystalline form. This inherent plasticity between the interconverting macrostates is compatible with a conformational-preselection model and provides new insights into the recognition mechanisms of SH3 domains." @default.
• W2908940596 created "2019-01-25" @default.
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• W2908940596 date "2019-01-08" @default.
• W2908940596 modified "2023-10-18" @default.
• W2908940596 title "Mechanistic Insights into Microsecond Time-Scale Motion of Solid Proteins Using Complementary ¹⁵N and ¹H Relaxation Dispersion Techniques" @default.
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• W2908940596 doi "https://doi.org/10.1021/jacs.8b09258" @default.
• W2908940596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6982537" @default.
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