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• W2909010161 abstract "Summary Background Recently, we reported a simple prognostic score for post‐engraftment invasive fungal disease ( IFD ) obtained in 404 adult allogeneic hematopoietic stem cell transplant (allo SCT ) (training cohort). Objectives We aim to validate this score in an external cohort assessing the 1‐year cumulative incidence ( CI ) of post‐engraftment IFD . Additionally, we analyse the type of IFD and incidence of IFD according to type of prophylaxis. Patients/methods We included 465 consecutive adult recipients surviving >40 days who engrafted and were discharged without prior IFD (median age 45 years, range, 14‐69). Results Patients classified as low‐risk, 139; intermediate‐risk, 162; and high‐risk, 164 (35% vs 27% in the training cohort, P = 0.03). The CI of probable/proven IFD in the validation cohort was 8% vs 11% in the training cohort ( P = 0.006). The only voriconazole prophylaxis used in the training cohort was 100 mg/12 h, 65% vs 27% in the validation cohort, but 38% received 200 mg/12 h. Thus, the validation cohort showed a lower CI of IFD ( P = 0.009). The post‐engraftment IFD score was validated, showing a CI of IFD for low‐, intermediate‐ and high‐risk of 3%, 6% and 14%, respectively ( P < 0.001). Conclusion To our knowledge, this is the first prognostic index to predict the occurrence of post‐engraftment IFD after alloSCT that has been validated in an external cohort." @default.
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• W2909010161 date "2019-03-08" @default.
• W2909010161 modified "2023-10-18" @default.
• W2909010161 title "Validation of a multivariable prediction model for post‐engraftment invasive fungal disease in 465 adult allogeneic hematopoietic stem cell transplant recipients" @default.
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• W2909010161 doi "https://doi.org/10.1111/myc.12891" @default.
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