Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909043795> ?p ?o ?g. }
- W2909043795 endingPage "625" @default.
- W2909043795 startingPage "597" @default.
- W2909043795 abstract "The aging of populations worldwide is driving greater demands for dietary polyphenols which have been recognized as promising prophylactic and/or therapeutic agents in the context of neurodegeneration, and are ubiquitously present in plant-based diets. In particular, grape-derived products encompass a wide array of phenolic compounds purported with multiple health benefits including neuroprotective efficacy. Despite the increasing preclinical and clinical evidence demonstrating high potential of grape polyphenol (GPP)-rich botanicals in preventing and attenuating diverse neurodegenerative disorders, the limited bioavailability of GPPs, especially in the brain, generates questions as to their applications and effectiveness in neuroprotection. To address this issue, significant research efforts have been made to enhance oral bioavailability of GPPs via application of novel strategies. This review highlights some critical issues related to the bioavailability and neuroprotective efficacy of GPPs and GPP-rich botanicals. The representative bioavailability-enhancing strategies are critically reviewed to provide practical solutions for augmenting the bioefficacy of GPP-rich botanicals. Synergistic applications of encapsulation techniques (for physiochemical protection and bypassing xenobiotic metabolism) and dietary intervention strategies involving modulation of gut microbiota (for generating more bioavailable phenolic metabolites) appear promising, and may substantially enhance the bioefficacy, especially the neuroprotective efficacy, of orally consumed GPPs." @default.
- W2909043795 created "2019-01-25" @default.
- W2909043795 creator A5041999258 @default.
- W2909043795 creator A5065463869 @default.
- W2909043795 creator A5065742203 @default.
- W2909043795 date "2019-01-07" @default.
- W2909043795 modified "2023-09-30" @default.
- W2909043795 title "A critical review on grape polyphenols for neuroprotection: Strategies to enhance bioefficacy" @default.
- W2909043795 cites W1189385401 @default.
- W2909043795 cites W1420784649 @default.
- W2909043795 cites W1505240513 @default.
- W2909043795 cites W1515187433 @default.
- W2909043795 cites W1526755650 @default.
- W2909043795 cites W1539910536 @default.
- W2909043795 cites W1548494899 @default.
- W2909043795 cites W1554223333 @default.
- W2909043795 cites W1602820987 @default.
- W2909043795 cites W1617825834 @default.
- W2909043795 cites W1633483043 @default.
- W2909043795 cites W1700603154 @default.
- W2909043795 cites W1861172520 @default.
- W2909043795 cites W1886477676 @default.
- W2909043795 cites W1909383564 @default.
- W2909043795 cites W1948827876 @default.
- W2909043795 cites W1964371958 @default.
- W2909043795 cites W1965878073 @default.
- W2909043795 cites W1965942744 @default.
- W2909043795 cites W1966697917 @default.
- W2909043795 cites W1969098308 @default.
- W2909043795 cites W1969570348 @default.
- W2909043795 cites W1970311360 @default.
- W2909043795 cites W1971120211 @default.
- W2909043795 cites W1973621432 @default.
- W2909043795 cites W1974126680 @default.
- W2909043795 cites W1974305753 @default.
- W2909043795 cites W1975049648 @default.
- W2909043795 cites W1976544976 @default.
- W2909043795 cites W1977463044 @default.
- W2909043795 cites W1979412780 @default.
- W2909043795 cites W1979967058 @default.
- W2909043795 cites W1980166999 @default.
- W2909043795 cites W1981500982 @default.
- W2909043795 cites W1982310709 @default.
- W2909043795 cites W1983595872 @default.
- W2909043795 cites W1983880012 @default.
- W2909043795 cites W1985148856 @default.
- W2909043795 cites W1985438873 @default.
- W2909043795 cites W1986110011 @default.
- W2909043795 cites W1989067086 @default.
- W2909043795 cites W1990164787 @default.
- W2909043795 cites W1991359947 @default.
- W2909043795 cites W1991897816 @default.
- W2909043795 cites W1996382452 @default.
- W2909043795 cites W1997003987 @default.
- W2909043795 cites W1997107160 @default.
- W2909043795 cites W1997543835 @default.
- W2909043795 cites W1997996740 @default.
- W2909043795 cites W2000224895 @default.
- W2909043795 cites W2001758981 @default.
- W2909043795 cites W2001784275 @default.
- W2909043795 cites W2003922368 @default.
- W2909043795 cites W2004173507 @default.
- W2909043795 cites W2004960233 @default.
- W2909043795 cites W2006496068 @default.
- W2909043795 cites W2006865962 @default.
- W2909043795 cites W2008495939 @default.
- W2909043795 cites W2012179823 @default.
- W2909043795 cites W2013057056 @default.
- W2909043795 cites W2013063327 @default.
- W2909043795 cites W2014787322 @default.
- W2909043795 cites W2016739577 @default.
- W2909043795 cites W2016977901 @default.
- W2909043795 cites W2017853225 @default.
- W2909043795 cites W2019032515 @default.
- W2909043795 cites W2019249853 @default.
- W2909043795 cites W2020730293 @default.
- W2909043795 cites W2025434504 @default.
- W2909043795 cites W2025791042 @default.
- W2909043795 cites W2026350063 @default.
- W2909043795 cites W2026392636 @default.
- W2909043795 cites W2026930707 @default.
- W2909043795 cites W2027465170 @default.
- W2909043795 cites W2031155126 @default.
- W2909043795 cites W2031806580 @default.
- W2909043795 cites W2031831329 @default.
- W2909043795 cites W2033773978 @default.
- W2909043795 cites W2034960280 @default.
- W2909043795 cites W2035448353 @default.
- W2909043795 cites W2037741483 @default.
- W2909043795 cites W2038857536 @default.
- W2909043795 cites W2039653166 @default.
- W2909043795 cites W2039851764 @default.
- W2909043795 cites W2040490831 @default.
- W2909043795 cites W2040874707 @default.
- W2909043795 cites W2041100273 @default.
- W2909043795 cites W2042232868 @default.
- W2909043795 cites W2043056355 @default.
- W2909043795 cites W2043320409 @default.