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- W290908084 abstract "In response to a need for an extracted brain blood flow tracer for positron tomograhy, the authors have developed from our original iodoamphetamine an I-122 radiopharmaceutical produced from a 20h Xe-122 generator and have demonstrated its application in animals and humans. The I-122 (t1/2 3.6m) is collected in the reaction vessel by a 10 min ingrowth from the Xe-122. The radiopharmaceutical, 2,4-dimethoxy-N,N-dimethyl-5(I-122)iodophenylisorpropylamine (5-(I-122)-2,4-DNNA), is synthesized using I-122 and chloramine-T, purified and sterilized for injection in 3 min. Synthesis can be repeated every 20-30 min. The diamine HIPDM was also labeled with I-122 by an exchange reaction for comparison. Using the Donner 280 crystal tomography system, anesthetized dogs showed rapid uptake of the activity in the brain using 5-(I-122)-2,4-DNNA and I-122 HIPDM. The ratio of activity in the brain to surrounding tissue was 6.1 and the distribution was the same as that from 18-FDG injected 30 min later." @default.
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- W290908084 date "1985-05-01" @default.
- W290908084 modified "2023-09-23" @default.
- W290908084 title "Generator produced I-122 labeled amines and diamines for brain blood flow measurements in neurologic disorders" @default.
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