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- W2909086976 abstract "Fibroblast growth factors (FGFs) are pleiotropic molecules exerting autocrine, intracrine and paracrine functions via activating four tyrosine kinase FGF receptors (FGFR), which further trigger a variety of cellular processes including angiogenesis, evasion from apoptosis, bone formation, embryogenesis, wound repair and homeostasis. Four major mechanisms including angiogenesis, inflammation, cell proliferation, and metastasis are active in FGF/FGFR-driven tumors. Furthermore, gain-of-function or loss-of-function in FGFRs1-4 which is due to amplification, fusions, mutations, and changes in tumor–stromal cells interactions, is associated with the development and progression of cancer. Although, the developed small molecule or antibodies targeting FGFR signaling offer immense potential for cancer therapy, emergence of drug resistance, activation of compensatory pathways and systemic toxicity of modulators are bottlenecks in clinical application of anti-FGFRs. In this review, we present FGF/FGFR structure and the mechanisms of its function, as well as cross-talks with other nodes and/or signaling pathways. We describe deregulation of FGF/FGFR-related mechanisms in human disease and tumor progression leading to the presentation of emerging therapeutic approaches, resistance to FGFR targeting, and clinical potentials of individual FGF family in several human cancers. Additionally, the underlying biological mechanisms of FGF/FGFR signaling, besides several attempts to develop predictive biomarkers and combination therapies for different cancers have been explored." @default.
- W2909086976 created "2019-01-25" @default.
- W2909086976 creator A5013527852 @default.
- W2909086976 creator A5055158419 @default.
- W2909086976 date "2019-05-10" @default.
- W2909086976 modified "2023-10-17" @default.
- W2909086976 title "Implications of Fibroblast Growth Factors (FGFs) in Cancer: From Prognostic to Therapeutic Applications" @default.
- W2909086976 cites W122651877 @default.
- W2909086976 cites W1483620247 @default.
- W2909086976 cites W1548791865 @default.
- W2909086976 cites W1894751757 @default.
- W2909086976 cites W1964039431 @default.
- W2909086976 cites W1965197845 @default.
- W2909086976 cites W1965727465 @default.
- W2909086976 cites W1965987206 @default.
- W2909086976 cites W1966963428 @default.
- W2909086976 cites W1968209756 @default.
- W2909086976 cites W1968303489 @default.
- W2909086976 cites W1968774351 @default.
- W2909086976 cites W1972429412 @default.
- W2909086976 cites W1975949921 @default.
- W2909086976 cites W1978914376 @default.
- W2909086976 cites W1981506621 @default.
- W2909086976 cites W1982901636 @default.
- W2909086976 cites W1983370176 @default.
- W2909086976 cites W1984961639 @default.
- W2909086976 cites W1985516721 @default.
- W2909086976 cites W1988476050 @default.
- W2909086976 cites W1989341870 @default.
- W2909086976 cites W1993450230 @default.
- W2909086976 cites W1993523589 @default.
- W2909086976 cites W1994927405 @default.
- W2909086976 cites W1997439414 @default.
- W2909086976 cites W1998625209 @default.
- W2909086976 cites W2000665430 @default.
- W2909086976 cites W2001716081 @default.
- W2909086976 cites W2002889122 @default.
- W2909086976 cites W2003686112 @default.
- W2909086976 cites W2004298061 @default.
- W2909086976 cites W2005156121 @default.
- W2909086976 cites W2005315810 @default.
- W2909086976 cites W2006688523 @default.
- W2909086976 cites W2008550171 @default.
- W2909086976 cites W2009717791 @default.
- W2909086976 cites W2009983682 @default.
- W2909086976 cites W2014368942 @default.
- W2909086976 cites W2014373387 @default.
- W2909086976 cites W2014440069 @default.
- W2909086976 cites W2015093334 @default.
- W2909086976 cites W2018177722 @default.
- W2909086976 cites W2019187446 @default.
- W2909086976 cites W2019711215 @default.
- W2909086976 cites W2019902366 @default.
- W2909086976 cites W2021600913 @default.
- W2909086976 cites W2021852822 @default.
- W2909086976 cites W2025183726 @default.
- W2909086976 cites W2026663929 @default.
- W2909086976 cites W2028384230 @default.
- W2909086976 cites W2028828556 @default.
- W2909086976 cites W2031663540 @default.
- W2909086976 cites W2031934366 @default.
- W2909086976 cites W2033054833 @default.
- W2909086976 cites W2034142713 @default.
- W2909086976 cites W2035252744 @default.
- W2909086976 cites W2036500329 @default.
- W2909086976 cites W2038373881 @default.
- W2909086976 cites W2042011375 @default.
- W2909086976 cites W2042814330 @default.
- W2909086976 cites W2045586178 @default.
- W2909086976 cites W2046356130 @default.
- W2909086976 cites W2048411348 @default.
- W2909086976 cites W2049828528 @default.
- W2909086976 cites W2049929333 @default.
- W2909086976 cites W2050271479 @default.
- W2909086976 cites W2050518514 @default.
- W2909086976 cites W2051575838 @default.
- W2909086976 cites W2052186115 @default.
- W2909086976 cites W2052997177 @default.
- W2909086976 cites W2055172928 @default.
- W2909086976 cites W2055565205 @default.
- W2909086976 cites W2056016311 @default.
- W2909086976 cites W2056133508 @default.
- W2909086976 cites W2056895322 @default.
- W2909086976 cites W2057620815 @default.
- W2909086976 cites W2060724191 @default.
- W2909086976 cites W2063283864 @default.
- W2909086976 cites W2063746351 @default.
- W2909086976 cites W2063820789 @default.
- W2909086976 cites W2064120191 @default.
- W2909086976 cites W2064582615 @default.
- W2909086976 cites W2066877588 @default.
- W2909086976 cites W2068523052 @default.
- W2909086976 cites W2070741791 @default.
- W2909086976 cites W2074363468 @default.
- W2909086976 cites W2076415360 @default.
- W2909086976 cites W2078435464 @default.
- W2909086976 cites W2078614587 @default.
- W2909086976 cites W2079014348 @default.