FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909103680> ?p ?o ?g. }

• W2909103680 abstract "ABSTRACT The long-term host effects caused by the protozoan parasite Toxoplasma gondii are poorly understood. RNA-seq analysis previously determined that the host response in the brain was higher and more complex at 28 versus 10 days postinfection. Here, we analyzed the host transcriptional profile of age-and sex-matched mice during early (21 and 28 days) and late (3 and 6 months) chronic infection. We found that a majority of the host genes which increase in abundance at day 21 postinfection are still increased 6 months postinfection for both male and female mice. While most of the differentially expressed genes were similar between sexes, females have far fewer genes that are significantly less abundant, which may lead to the slight increased cyst burden in males. Transcripts for C-X-C Motif Chemokine Ligand 13 (CXCL13) and a C-C Motif Chemokine Receptor 2 (CCR2) were significantly higher in females compared to males during infection. As T. gondii chronic infection and profilin (PRF) confer resistance to Listeria monocytogenes infection in a CCR2 dependent manner, the sex specific difference in CCR2 expression lead us to re-test the protection of PRF in both sexes. Chronic infection as well as PRF were nearly as effective at reducing the bacterial burden in male versus female mice. These data show that most of the differentially express host genes are similar between males and females, important differences exist leading us to emphasize the inclusion of both sexes for future studies." @default.
• W2909103680 created "2019-01-25" @default.
• W2909103680 creator A5010565657 @default.
• W2909103680 creator A5035241950 @default.
• W2909103680 creator A5052764419 @default.
• W2909103680 date "2019-01-17" @default.
• W2909103680 modified "2023-09-25" @default.
• W2909103680 title "Transcriptional analysis shows a robust host response to Toxoplasma gondii during early and late chronic infection in both male and female mice" @default.
• W2909103680 cites W1481332551 @default.
• W2909103680 cites W1502715241 @default.
• W2909103680 cites W1970279912 @default.
• W2909103680 cites W1981277516 @default.
• W2909103680 cites W1982763490 @default.
• W2909103680 cites W1983430686 @default.
• W2909103680 cites W1988363406 @default.
• W2909103680 cites W1988450656 @default.
• W2909103680 cites W1998047654 @default.
• W2909103680 cites W1998077604 @default.
• W2909103680 cites W1999574084 @default.
• W2909103680 cites W2003486730 @default.
• W2909103680 cites W2009521410 @default.
• W2909103680 cites W2019689527 @default.
• W2909103680 cites W2020541351 @default.
• W2909103680 cites W2022028941 @default.
• W2909103680 cites W2030588393 @default.
• W2909103680 cites W2043469298 @default.
• W2909103680 cites W2048571527 @default.
• W2909103680 cites W2076315468 @default.
• W2909103680 cites W2105111638 @default.
• W2909103680 cites W2111200149 @default.
• W2909103680 cites W2112809298 @default.
• W2909103680 cites W2124836944 @default.
• W2909103680 cites W2133051121 @default.
• W2909103680 cites W2154568785 @default.
• W2909103680 cites W2156497943 @default.
• W2909103680 cites W2156665864 @default.
• W2909103680 cites W2161295311 @default.
• W2909103680 cites W2163021526 @default.
• W2909103680 cites W2169101403 @default.
• W2909103680 cites W2169456326 @default.
• W2909103680 cites W2277975317 @default.
• W2909103680 cites W2301894725 @default.
• W2909103680 cites W2313270174 @default.
• W2909103680 cites W2518901523 @default.
• W2909103680 cites W2751445085 @default.
• W2909103680 cites W31374100 @default.
• W2909103680 cites W2078028477 @default.
• W2909103680 doi "https://doi.org/10.1101/523183" @default.
• W2909103680 hasPublicationYear "2019" @default.
• W2909103680 type Work @default.
• W2909103680 sameAs 2909103680 @default.
• W2909103680 citedByCount "0" @default.
• W2909103680 crossrefType "posted-content" @default.
• W2909103680 hasAuthorship W2909103680A5010565657 @default.
• W2909103680 hasAuthorship W2909103680A5035241950 @default.
• W2909103680 hasAuthorship W2909103680A5052764419 @default.
• W2909103680 hasBestOaLocation W29091036801 @default.
• W2909103680 hasConcept C104317684 @default.
• W2909103680 hasConcept C126831891 @default.
• W2909103680 hasConcept C12823836 @default.
• W2909103680 hasConcept C13373296 @default.
• W2909103680 hasConcept C136764020 @default.
• W2909103680 hasConcept C150194340 @default.
• W2909103680 hasConcept C159654299 @default.
• W2909103680 hasConcept C162317418 @default.
• W2909103680 hasConcept C203014093 @default.
• W2909103680 hasConcept C206615009 @default.
• W2909103680 hasConcept C2778128430 @default.
• W2909103680 hasConcept C2781350384 @default.
• W2909103680 hasConcept C3019392825 @default.
• W2909103680 hasConcept C41008148 @default.
• W2909103680 hasConcept C523546767 @default.
• W2909103680 hasConcept C54355233 @default.
• W2909103680 hasConcept C71928629 @default.
• W2909103680 hasConcept C75877943 @default.
• W2909103680 hasConcept C86803240 @default.
• W2909103680 hasConcept C8891405 @default.
• W2909103680 hasConceptScore W2909103680C104317684 @default.
• W2909103680 hasConceptScore W2909103680C126831891 @default.
• W2909103680 hasConceptScore W2909103680C12823836 @default.
• W2909103680 hasConceptScore W2909103680C13373296 @default.
• W2909103680 hasConceptScore W2909103680C136764020 @default.
• W2909103680 hasConceptScore W2909103680C150194340 @default.
• W2909103680 hasConceptScore W2909103680C159654299 @default.
• W2909103680 hasConceptScore W2909103680C162317418 @default.
• W2909103680 hasConceptScore W2909103680C203014093 @default.
• W2909103680 hasConceptScore W2909103680C206615009 @default.
• W2909103680 hasConceptScore W2909103680C2778128430 @default.
• W2909103680 hasConceptScore W2909103680C2781350384 @default.
• W2909103680 hasConceptScore W2909103680C3019392825 @default.
• W2909103680 hasConceptScore W2909103680C41008148 @default.
• W2909103680 hasConceptScore W2909103680C523546767 @default.
• W2909103680 hasConceptScore W2909103680C54355233 @default.
• W2909103680 hasConceptScore W2909103680C71928629 @default.
• W2909103680 hasConceptScore W2909103680C75877943 @default.
• W2909103680 hasConceptScore W2909103680C86803240 @default.
• W2909103680 hasConceptScore W2909103680C8891405 @default.
• W2909103680 hasLocation W29091036801 @default.
• W2909103680 hasOpenAccess W2909103680 @default.
• W2909103680 hasPrimaryLocation W29091036801 @default.

• next