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- W2909132011 abstract "TIGIT is an inhibitory immune checkpoint receptor and a putative target for novel immune therapies. Here, we analysed two different types of tissue microarrays of healthy lymphatic and various inflamed tissues, colorectal and lung cancers, as well as >1700 tumour samples from 86 different tumour entities for TIGIT and/or PD-1 by bright field and/or multiplex fluorescence immunohistochemistry. TIGIT was detected in CD8 + cytotoxic T cells, CD4 + T helper cells, FOXP3 + regulatory T cells, and NK cells, but not in CD11c + dendritic cells, CD68 + macrophages, and CD20 + B lymphocytes. TIGIT expression paralleled that of PD-1. More than 70% of TIGIT + cells were PD-1 + , and more than 90% of the PD-1 + cells were TIGIT + . Expression varied between different tissue compartments. TIGIT expression in tonsil gradually increased from the interfollicular area over the marginal/mantle zone to the germinal centre in all T cell subtypes. In inflammatory diseases, the strongest expression of TIGIT/PD-1 was found in Hashimoto thyroiditis. TIGIT + lymphocytes were seen in all 86 different tumour entities with considerable high variability of TIGIT positivity within and between different cancer entities. Particularly, high densities of TIGIT + lymphocytes were, for example, seen in squamous cell cancers of various origins. In summary, the variable expression levels of TIGIT and PD-1 in cell types and tissue compartments illustrate the high complexity of immune microenvironments. The high frequency of TIGIT (and PD-1) expressing lymphocytes in cancers highlights considerable opportunities for cotargeting with checkpoint inhibitors." @default.
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- W2909132011 date "2019-01-10" @default.
- W2909132011 modified "2023-10-11" @default.
- W2909132011 title "Patterns of TIGIT Expression in Lymphatic Tissue, Inflammation, and Cancer" @default.
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- W2909132011 doi "https://doi.org/10.1155/2019/5160565" @default.
- W2909132011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6348838" @default.
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