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- W2909182777 abstract "Parkinson's disease (PD) is mostly known as a dopamine deficiency syndrome due the structural and functional changes in striatal projection neurons. However, studies have considered this pathology as a multi-systemic disease in which the neurodegenerative process extends beyond the dopaminergic system. Therefore, the purpose of the present study was to investigate the morphological and immunohistochemical changes associated with behavioral and cognitive alterations in a model of parkinsonism induced by low dose of reserpine. Animals showed anxiety-like behavior and deficits in short-term recognition memory. Besides, Tyrosine Hydroxylase (TH) immunoreactive cells decreased in reserpine (RES) group in CA1 and serotonin (5-HT) immunoreactive cells decreased in RES group in CA1, CA3 and medial prefrontal cortex (mPFC). Moreover, an increase in the area (μm2) of 5 H T labeled ultrastructure (axon terminal) was observed in RES group only in CA1 and mPFC. The evidence of alterations in 5-HT immunoreactive in the premotor phase of model of parkinsonism highlights the importance of looking beyond the nigrostriatal system to elucidate the underling mechanisms and deficits in other neurotransmitters systems. This provides vital information regarding novel interventions for the management of non-motor symptoms. Additionally, the low-dose reserpine treatment has an early effect on axonal ultrastructure. As the axonopathy in PD has been increasingly recognized, the focus on axonal neurobiology is noteworthy for both neuroprotective and restorative therapeutics, and the progressive reserpine rat model can be a useful tool in this search." @default.
- W2909182777 created "2019-01-25" @default.
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- W2909182777 date "2019-03-01" @default.
- W2909182777 modified "2023-10-10" @default.
- W2909182777 title "Cognitive and anxiety-like impairments accompanied by serotonergic ultrastructural and immunohistochemical alterations in early stages of parkinsonism" @default.
- W2909182777 cites W1237068170 @default.
- W2909182777 cites W1502339857 @default.
- W2909182777 cites W1504584187 @default.
- W2909182777 cites W1509873093 @default.
- W2909182777 cites W1545877169 @default.
- W2909182777 cites W1583093482 @default.
- W2909182777 cites W1805914682 @default.
- W2909182777 cites W1809702059 @default.
- W2909182777 cites W1875368380 @default.
- W2909182777 cites W1964156528 @default.
- W2909182777 cites W1965222925 @default.
- W2909182777 cites W1966037459 @default.
- W2909182777 cites W1967659552 @default.
- W2909182777 cites W1982535961 @default.
- W2909182777 cites W1988173316 @default.
- W2909182777 cites W1989040635 @default.
- W2909182777 cites W1989098288 @default.
- W2909182777 cites W1989123455 @default.
- W2909182777 cites W1989734945 @default.
- W2909182777 cites W1994017777 @default.
- W2909182777 cites W1995271633 @default.
- W2909182777 cites W1997497060 @default.
- W2909182777 cites W1998487518 @default.
- W2909182777 cites W1999385317 @default.
- W2909182777 cites W1999499099 @default.
- W2909182777 cites W2011931872 @default.
- W2909182777 cites W2022155997 @default.
- W2909182777 cites W2022533807 @default.
- W2909182777 cites W2022947342 @default.
- W2909182777 cites W2025375665 @default.
- W2909182777 cites W2027189759 @default.
- W2909182777 cites W2028911868 @default.
- W2909182777 cites W2031173917 @default.
- W2909182777 cites W2034104365 @default.
- W2909182777 cites W2034688662 @default.
- W2909182777 cites W2042436410 @default.
- W2909182777 cites W2042726084 @default.
- W2909182777 cites W2046922635 @default.
- W2909182777 cites W2049625114 @default.
- W2909182777 cites W2052354629 @default.
- W2909182777 cites W2052866748 @default.
- W2909182777 cites W2056087700 @default.
- W2909182777 cites W2065000444 @default.
- W2909182777 cites W2065843212 @default.
- W2909182777 cites W2069515205 @default.
- W2909182777 cites W2072536713 @default.
- W2909182777 cites W2073449985 @default.
- W2909182777 cites W2073687920 @default.
- W2909182777 cites W2077918856 @default.
- W2909182777 cites W2110413824 @default.
- W2909182777 cites W2110645708 @default.
- W2909182777 cites W2111034192 @default.
- W2909182777 cites W2116958494 @default.
- W2909182777 cites W2118178037 @default.
- W2909182777 cites W2119391460 @default.
- W2909182777 cites W2120001716 @default.
- W2909182777 cites W2121007598 @default.
- W2909182777 cites W2124680543 @default.
- W2909182777 cites W2131881760 @default.
- W2909182777 cites W2137404075 @default.
- W2909182777 cites W2144531560 @default.
- W2909182777 cites W2149341227 @default.
- W2909182777 cites W2152670250 @default.
- W2909182777 cites W2154937615 @default.
- W2909182777 cites W2172105174 @default.
- W2909182777 cites W2179162623 @default.
- W2909182777 cites W2239049730 @default.
- W2909182777 cites W2266447459 @default.
- W2909182777 cites W2311228285 @default.
- W2909182777 cites W2467732139 @default.
- W2909182777 cites W2481634574 @default.
- W2909182777 cites W2617346135 @default.
- W2909182777 cites W2741847361 @default.
- W2909182777 cites W2766455571 @default.
- W2909182777 cites W2793171113 @default.
- W2909182777 cites W4246543557 @default.
- W2909182777 doi "https://doi.org/10.1016/j.brainresbull.2019.01.009" @default.
- W2909182777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30641120" @default.
- W2909182777 hasPublicationYear "2019" @default.
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