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• W2909208475 abstract "An approach to the study of dendritic cells (DCs) biology is to examine the in vivo functions of DCs in mice with defects in relevant genes. In normal mice, RelB is normally constitutively expressed in only a few cells—DCs of lymphoid tissues and a subset of thymic medullary epithelial cells. As for DCs, development is not so easily attributed to RelB expression. Because the expression of RelB is only associated with DCs that have arrived in the draining lymph nodes, a deficiency in RelB would not be expected to alter the development of DC precursors such as Langerhans cells. Indeed, RelB knockout mice appear to have normal numbers of Langerhans cells in the skin, and DC precursors appear to be present in other tissues as well. Because these precursors can develop to a fairly differentiated stage in the absence of RelB, deficiencies in RelB can have rather subtle and complex effects on the final stages in DC differentiation." @default.
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• W2909208475 date "2001-01-01" @default.
• W2909208475 modified "2023-09-26" @default.
• W2909208475 title "Targeted knockouts affecting DCs" @default.
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• W2909208475 doi "https://doi.org/10.1016/b978-012455851-9/50048-1" @default.
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