FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909243669> ?p ?o ?g. }

• W2909243669 endingPage "319" @default.
• W2909243669 startingPage "311" @default.
• W2909243669 abstract "Objective: This study was undertaken to investigate the effect of C225 on the radio-sensitivity of MDA-MB-231 cells line and to disclosure underlying mechanism. Methods: CCK8 assay was used to measure the proliferation inhibition of C225 on MDA-MB-231 cells. The combined effects of C225 plus radiation on the proliferation of MDA-MB-231 cells were also evaluated by CCK-8 assay. The clonogenic assay was performed to evaluate the cell surviving fractions and to determine the radio-sensitizing effect of C225 on MDA-MB-231 cells. The apoptosis and cell cycle distribution were analyzed by flow cytometry. Western blot analysis was used to detect the expression of p-EGFR, p-Akt, p-P38, and caspase-3. Results: C225 had an inhibiting effect on the proliferation of cells in a concentration-dependent manner. The cloning formation capacity was decreased in C225 plus radiation group. C225 increased radio-sensitivity of cells and led to cell cycle arrest in G0/G1 phase markedly. Cells treated with C225 and radiation predominantly exhibited G0/G1 phase arrest and significant decreased in the fraction of cells in the S phase. Moreover, C225 and radiation significantly increased the apoptosis rate of cells. Decreased cell proliferation was further supported by the down-regulation of p-EGFR and its downstream singling pathway proteins such as p-Akt and p-P38. The up-regulation of the Caspase-3 expression in C225 plus radiation group revealed that C225 could increase radiation-inducing cell apoptosis. Conclusion: C225 could increase the radio-sensitivity of cells, which may be due to the anti-proliferative synergistic effect between C225 and radiation as well as the down-regulation of the PI3K/Akt signaling pathway." @default.
• W2909243669 created "2019-01-25" @default.
• W2909243669 creator A5000286768 @default.
• W2909243669 creator A5002248468 @default.
• W2909243669 creator A5013280301 @default.
• W2909243669 creator A5029662680 @default.
• W2909243669 creator A5039858613 @default.
• W2909243669 creator A5061332222 @default.
• W2909243669 creator A5075821995 @default.
• W2909243669 creator A5089632289 @default.
• W2909243669 date "2019-01-01" @default.
• W2909243669 modified "2023-10-14" @default.
• W2909243669 title "EGFR inhibitor C225 Increases the Radio-Sensitivity of Human Breast Cancer Cells" @default.
• W2909243669 cites W1603239391 @default.
• W2909243669 cites W1939136117 @default.
• W2909243669 cites W1968366677 @default.
• W2909243669 cites W1984559226 @default.
• W2909243669 cites W2013123523 @default.
• W2909243669 cites W2022006860 @default.
• W2909243669 cites W2029854123 @default.
• W2909243669 cites W2035258932 @default.
• W2909243669 cites W2058645214 @default.
• W2909243669 cites W2060745847 @default.
• W2909243669 cites W2077098370 @default.
• W2909243669 cites W2087987371 @default.
• W2909243669 cites W2100484302 @default.
• W2909243669 cites W2102515900 @default.
• W2909243669 cites W2105288740 @default.
• W2909243669 cites W2106787323 @default.
• W2909243669 cites W2109126978 @default.
• W2909243669 cites W2125073303 @default.
• W2909243669 cites W2140407529 @default.
• W2909243669 cites W2142093446 @default.
• W2909243669 cites W2145931837 @default.
• W2909243669 cites W2151161412 @default.
• W2909243669 cites W2154745425 @default.
• W2909243669 cites W2155127624 @default.
• W2909243669 cites W2162527007 @default.
• W2909243669 cites W2181416514 @default.
• W2909243669 cites W2345520280 @default.
• W2909243669 cites W2465789943 @default.
• W2909243669 cites W2566317011 @default.
• W2909243669 cites W2724177236 @default.
• W2909243669 cites W2799501577 @default.
• W2909243669 cites W2803400551 @default.
• W2909243669 cites W2884841735 @default.
• W2909243669 doi "https://doi.org/10.31557/apjcp.2019.20.1.311" @default.
• W2909243669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6485551" @default.
• W2909243669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30678455" @default.
• W2909243669 hasPublicationYear "2019" @default.
• W2909243669 type Work @default.
• W2909243669 sameAs 2909243669 @default.
• W2909243669 citedByCount "7" @default.
• W2909243669 countsByYear W29092436692020 @default.
• W2909243669 countsByYear W29092436692021 @default.
• W2909243669 countsByYear W29092436692022 @default.
• W2909243669 crossrefType "journal-article" @default.
• W2909243669 hasAuthorship W2909243669A5000286768 @default.
• W2909243669 hasAuthorship W2909243669A5002248468 @default.
• W2909243669 hasAuthorship W2909243669A5013280301 @default.
• W2909243669 hasAuthorship W2909243669A5029662680 @default.
• W2909243669 hasAuthorship W2909243669A5039858613 @default.
• W2909243669 hasAuthorship W2909243669A5061332222 @default.
• W2909243669 hasAuthorship W2909243669A5075821995 @default.
• W2909243669 hasAuthorship W2909243669A5089632289 @default.
• W2909243669 hasBestOaLocation W29092436691 @default.
• W2909243669 hasConcept C105696609 @default.
• W2909243669 hasConcept C117262875 @default.
• W2909243669 hasConcept C153911025 @default.
• W2909243669 hasConcept C185592680 @default.
• W2909243669 hasConcept C190283241 @default.
• W2909243669 hasConcept C29537977 @default.
• W2909243669 hasConcept C502942594 @default.
• W2909243669 hasConcept C51551487 @default.
• W2909243669 hasConcept C54355233 @default.
• W2909243669 hasConcept C553184892 @default.
• W2909243669 hasConcept C55493867 @default.
• W2909243669 hasConcept C57074206 @default.
• W2909243669 hasConcept C62112901 @default.
• W2909243669 hasConcept C62478195 @default.
• W2909243669 hasConcept C75217442 @default.
• W2909243669 hasConcept C81885089 @default.
• W2909243669 hasConcept C86803240 @default.
• W2909243669 hasConceptScore W2909243669C105696609 @default.
• W2909243669 hasConceptScore W2909243669C117262875 @default.
• W2909243669 hasConceptScore W2909243669C153911025 @default.
• W2909243669 hasConceptScore W2909243669C185592680 @default.
• W2909243669 hasConceptScore W2909243669C190283241 @default.
• W2909243669 hasConceptScore W2909243669C29537977 @default.
• W2909243669 hasConceptScore W2909243669C502942594 @default.
• W2909243669 hasConceptScore W2909243669C51551487 @default.
• W2909243669 hasConceptScore W2909243669C54355233 @default.
• W2909243669 hasConceptScore W2909243669C553184892 @default.
• W2909243669 hasConceptScore W2909243669C55493867 @default.
• W2909243669 hasConceptScore W2909243669C57074206 @default.
• W2909243669 hasConceptScore W2909243669C62112901 @default.
• W2909243669 hasConceptScore W2909243669C62478195 @default.
• W2909243669 hasConceptScore W2909243669C75217442 @default.

• next