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• W2909271070 endingPage "84" @default.
• W2909271070 startingPage "43" @default.
• W2909271070 abstract "Dormancy occurs when cells remain viable but stop proliferating. When most of a cancer population undergoes this phenomenon, the result is called tumor dormancy, and when a single cancer cell undergoes this process, it is termed quiescence. Cancer stem cells (CSCs) share several overlapping characteristics and signaling pathways with dormant cancer cells, including therapy resistance, and an ability to metastasize and evade the immune system. Cancer cells can be broadly grouped into dormancy-competent CSCs (DCCs), cancer-repopulating cells (CRCs), dormancy-incompetent CSCs and disseminated tumor cells (DTCs). The settings in which cancer cells exploit the dormancy phase to survive and adapt are: (i) primary cancer dormancy; (ii) metastatic dormancy; (iii) therapy-induced dormancy; and (iv) immunologic dormancy. Dormancy, therapy resistance and plasticity of CSCs are fundamentally interconnected processes mediated through mechanisms involving reversible genetic alterations. Niches including metastatic, bone marrow, and perivascular are known to harbor dormant cancer cells. Mechanisms of dormancy induction are complex and multi-factorial and can involve angiogenic switching, addictive oncogene inhibition, immunoediting, anoikis, therapy, autophagy, senescence, epigenetic, and biophysical regulation. Therapy can have opposing effects on cancer cells with respect to dormancy; some therapies can induce dormancy, while others can reactivate dormant cells. There is a lack of consensus relative to the value of therapy-induced dormancy, i.e., some researchers view dormancy induction as a beneficial strategy as it can lead to metastasis inhibition, while others argue that reactivating dormant cancer cells and then eliminating them through therapy are a better approach. More focused investigations of intrinsic cell kinetics and environmental dynamics that promote and maintain cancer cells in a dormant state, and the long-term consequences of dormancy are critical for improving current therapeutic treatment outcomes." @default.
• W2909271070 created "2019-01-25" @default.
• W2909271070 creator A5005223730 @default.
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• W2909271070 creator A5085761427 @default.
• W2909271070 creator A5091194969 @default.
• W2909271070 date "2019-01-01" @default.
• W2909271070 modified "2023-10-12" @default.
• W2909271070 title "Dormancy and cancer stem cells: An enigma for cancer therapeutic targeting" @default.
• W2909271070 cites W1230611947 @default.
• W2909271070 cites W1495945591 @default.
• W2909271070 cites W1526274673 @default.
• W2909271070 cites W1561537870 @default.
• W2909271070 cites W1601070508 @default.
• W2909271070 cites W1601336165 @default.
• W2909271070 cites W1761343402 @default.
• W2909271070 cites W1833894759 @default.
• W2909271070 cites W1835915349 @default.
• W2909271070 cites W1901860734 @default.
• W2909271070 cites W1971481045 @default.
• W2909271070 cites W1971777358 @default.
• W2909271070 cites W1973300568 @default.
• W2909271070 cites W1973583684 @default.
• W2909271070 cites W1978724459 @default.
• W2909271070 cites W1980247655 @default.
• W2909271070 cites W1980878904 @default.
• W2909271070 cites W1981968613 @default.
• W2909271070 cites W1985558623 @default.
• W2909271070 cites W1987551912 @default.
• W2909271070 cites W1990116612 @default.
• W2909271070 cites W1990425294 @default.
• W2909271070 cites W1990876362 @default.
• W2909271070 cites W1991215014 @default.
• W2909271070 cites W1993322072 @default.
• W2909271070 cites W1993497779 @default.
• W2909271070 cites W1995075648 @default.
• W2909271070 cites W1996113298 @default.
• W2909271070 cites W1999782631 @default.
• W2909271070 cites W2000474379 @default.
• W2909271070 cites W2000915272 @default.
• W2909271070 cites W2004273407 @default.
• W2909271070 cites W2005405352 @default.
• W2909271070 cites W2005734249 @default.
• W2909271070 cites W2006464386 @default.
• W2909271070 cites W2006931309 @default.
• W2909271070 cites W2006986876 @default.
• W2909271070 cites W2007754809 @default.
• W2909271070 cites W2009134006 @default.
• W2909271070 cites W2010589579 @default.
• W2909271070 cites W2011084862 @default.
• W2909271070 cites W2011776457 @default.
• W2909271070 cites W2011997876 @default.
• W2909271070 cites W2012487145 @default.
• W2909271070 cites W2014624348 @default.
• W2909271070 cites W2014691022 @default.
• W2909271070 cites W2016488651 @default.
• W2909271070 cites W2017981906 @default.
• W2909271070 cites W2018288777 @default.
• W2909271070 cites W2020426410 @default.
• W2909271070 cites W2022179692 @default.
• W2909271070 cites W2022861507 @default.
• W2909271070 cites W2022891382 @default.
• W2909271070 cites W2022904684 @default.
• W2909271070 cites W2023980114 @default.
• W2909271070 cites W2024225603 @default.
• W2909271070 cites W2024449289 @default.
• W2909271070 cites W2026990179 @default.
• W2909271070 cites W2028672331 @default.
• W2909271070 cites W2030689322 @default.
• W2909271070 cites W2031182614 @default.
• W2909271070 cites W2032220572 @default.
• W2909271070 cites W2037133813 @default.
• W2909271070 cites W2037236573 @default.
• W2909271070 cites W2039403501 @default.
• W2909271070 cites W2042278676 @default.
• W2909271070 cites W2043297474 @default.
• W2909271070 cites W2045000546 @default.
• W2909271070 cites W2046935809 @default.
• W2909271070 cites W2049016944 @default.
• W2909271070 cites W2050224146 @default.
• W2909271070 cites W2052467200 @default.
• W2909271070 cites W2052569390 @default.
• W2909271070 cites W2054657650 @default.
• W2909271070 cites W2056716232 @default.
• W2909271070 cites W2056984964 @default.
• W2909271070 cites W2061965920 @default.
• W2909271070 cites W2064262178 @default.
• W2909271070 cites W2064998209 @default.
• W2909271070 cites W2066727453 @default.
• W2909271070 cites W2068480866 @default.
• W2909271070 cites W2068503417 @default.
• W2909271070 cites W2069053195 @default.
• W2909271070 cites W2070224555 @default.
• W2909271070 cites W2070291618 @default.
• W2909271070 cites W2071123870 @default.
• W2909271070 cites W2071735670 @default.

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