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- W2909283919 abstract "Background Systemic sclerosis-related interstitial lung disease (SSc-ILD) is the leading cause of death in SSc. Predictors of the outcomes of ILD in SSc are under investigation. Objectives to assess association of the digital ulcers with dynamics of forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DLco) in patients with SSc-ILD. Methods It was a longitudinal study involving 83 pts with SSc-ILD (mean age was 46,2±13,4; 69% have limited subset of the disease; 95% were female). The mean duration of follow up was 58,9±12,0 months. At the end of the study a number of pts with digital ulcers (DUs) was 29 (35%). Additionally 77 pts. with SSc-ILD were investigated with HRCT and were divided into 3 groups; The 1 st group (16 pts) with improvement; 2nd group (39 pts) without any changes and 3rd group (22 pts) with worsening of fibrosis. Results After 5 years of follow up FVC increased significantly in all pts without DUs (n=54) from 88,5%±19 to 96%±23 (p 0,05). The mean value of FVC in all pts with DUs didn’t change (88%±14 and 86%±16, p>0,05) with tendency to decreasing in group 3 (from 83%±12,5 to 74%±13 (p>0,05). After 5 years of follow up DLco declined significantly in all pts with or without DUs, however in the 1 st group decline of DLco wasn’t significant. The decreasing of DLCO was more prominent in group 3 than in group 2. Therefore, in group 2 in patient without DU (n=24) – from 65%±16 to 60%±11 (p Conclusions In patients without DUs significant increasing of FVC during 5 years long follow up was observed. The worsening of fibrosis on HRCT in pts with DUs was associated with the lowest value of FVC and DLco at the entry and at the end of the study. Disclosure of Interest None declared" @default.
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- W2909283919 date "2018-06-01" @default.
- W2909283919 modified "2023-09-23" @default.
- W2909283919 title "FRI0457 Relationship between digital ulcers and severity of lung function test in systemic sclerosis over a five-year period" @default.
- W2909283919 doi "https://doi.org/10.1136/annrheumdis-2018-eular.4509" @default.
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