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- W2909303043 abstract "To the Editor: Biotin, or vitamin B7, is essential for metabolic pathways, but supplementation is unnecessary for patients who are following a normal Western diet and do not have any malabsorption issues or nutrient deficiencies.1Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate OBV and CDietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academies Press, Washington, DC1998https://doi.org/10.17226/6015Google Scholar Although there is limited evidence that biotin supplementation improves skin, hair, and nail conditions, it is routinely recommended by dermatologists and primary care physicians.2Lipner S.R. Rethinking biotin therapy for hair, nail, and skin disorders.J Am Acad Dermatol. 2018; 78: 1236-1238Google Scholar, 3Lipner S.R. Scher R.K. Biotin for the treatment of nail disease: what is the evidence?.J Dermatolog Treat. 2018; 29: 411-414Google Scholar, 4Patel D.P. Swink S.M. Castelo-Soccio L. A review of the use of biotin for hair loss.Skin Appendage Disord. 2017; 3: 166-169Google Scholar A recent US Food and Drug Administration warning stated that biotin supplementation can interfere with laboratory tests, potentially leading to missed or inappropriate diagnoses with clinical implications.5US Food and Drug AdministrationThe FDA warns that biotin may interfere with lab tests: FDA safety communication.https://www.fda.gov/medicaldevices/safety/alertsandnotices/ucm586505.htmDate accessed: September 3, 2018Google Scholar An anonymous voluntary survey was administered to patients at Weill Cornell Medicine Dermatology from June 4 to June 20, 2018, after institutional review board approval. All statistical analyses and graphics were produced by using the R software (version 3.5.1, R Foundation for Statistical Computing, Vienna, Austria). A total of 447 participants were enrolled in the study, and 152 subjects (33.7%) indicated current (n = 61 [13.5%]) or past (n = 91 [20.2%]) biotin use. Of the 152 biotin users, 88 (57.9%) reported no improvement in their conditions with biotin. Of the 62 patients who benefited from biotin use, 17 (27.4%) reported improvement in hair and nails (Fig 1). Either a primary care physician or dermatologist had recommended biotin to 28.8% of the biotin users, and 54.6% of users had self-prescribed biotin. Only 4.7% of all participants and 6.6% of the biotin users were aware of the US Food and Drug Administration warning. Only 6 subjects were informed of this warning by their physician. Of the biotin users, 56.2% underwent laboratory testing while taking biotin. Our study demonstrates that biotin intake is highly prevalent in patients attending a dermatology clinic at an urban academic medical center despite the lack of clinical evidence showing benefit for dermatologic conditions.2Lipner S.R. Rethinking biotin therapy for hair, nail, and skin disorders.J Am Acad Dermatol. 2018; 78: 1236-1238Google Scholar, 3Lipner S.R. Scher R.K. Biotin for the treatment of nail disease: what is the evidence?.J Dermatolog Treat. 2018; 29: 411-414Google Scholar, 4Patel D.P. Swink S.M. Castelo-Soccio L. A review of the use of biotin for hair loss.Skin Appendage Disord. 2017; 3: 166-169Google Scholar These findings may not be generalizable to other populations. Although the effect of biotin on normal nails is unknown, prior studies have suggested that biotin supplementation improves brittle nails, triangular worn-down nails, trachyonychia, and habit-tic nail deformity. Biotin has been used for hair disorders, but most patients who exhibited improvement had inherited or acquired biotin deficiencies.4Patel D.P. Swink S.M. Castelo-Soccio L. A review of the use of biotin for hair loss.Skin Appendage Disord. 2017; 3: 166-169Google Scholar Alteration in laboratory troponin levels with biotin, resulting in a missed diagnosis of myocardial infarction, has been reported.5US Food and Drug AdministrationThe FDA warns that biotin may interfere with lab tests: FDA safety communication.https://www.fda.gov/medicaldevices/safety/alertsandnotices/ucm586505.htmDate accessed: September 3, 2018Google Scholar Biotin supplementation has resulted in biochemical Graves disease in euthyroid individuals, leading to unnecessary treatments. Given its potential to affect common laboratory test results and the lack of sufficient evidence regarding its benefit, biotin should not be routinely recommended by physicians. Physicians should be educated about the risks and benefits of biotin use and should confirm biotin deficiency via laboratory assays before recommending supplementation. Patients should be encouraged to inform their physicians about biotin use. We suggest that laboratories include a check box for biotin supplementation on their requisitions, given the possible alteration of laboratory values." @default.
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- W2909303043 date "2019-08-01" @default.
- W2909303043 modified "2023-09-26" @default.
- W2909303043 title "Assessment of biotin supplementation among patients in an outpatient dermatology clinic" @default.
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- W2909303043 doi "https://doi.org/10.1016/j.jaad.2018.12.045" @default.
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