FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909346791> ?p ?o ?g. }

• W2909346791 abstract "Linear mixed models (LMMs) are widely used for heritability estimation in genome-wide association studies (GWAS). In standard approaches to heritability estimation with LMMs, a genetic relationship matrix (GRM) must be specified. In GWAS, the GRM is frequently a correlation matrix estimated from the study population's genotypes, which corresponds to a normalized Euclidean distance kernel. In this paper, we show that reliance on the Euclidean distance kernel contributes to several unresolved modeling inconsistencies in heritability estimation for GWAS. These inconsistencies can cause biased heritability estimates in the presence of linkage disequilibrium (LD), depending on the distribution of causal variants. We show that these biases can be resolved (at least at the modeling level) if one adopts a Mahalanobis distance-based GRM for LMM analysis. Additionally, we propose a new definition of partitioned heritability -- the heritability attributable to a subset of genes or single nucleotide polymorphisms (SNPs) -- using the Mahalanobis GRM, and show that it inherits many of the nice consistency properties identified in our original analysis. Partitioned heritability is a relatively new area for GWAS analysis, where inconsistency issues related to LD have previously been known to be especially pernicious." @default.
• W2909346791 created "2019-01-25" @default.
• W2909346791 creator A5011372682 @default.
• W2909346791 creator A5025052206 @default.
• W2909346791 date "2019-01-09" @default.
• W2909346791 modified "2023-09-24" @default.
• W2909346791 title "The Mahalanobis kernel for heritability estimation in genome-wide association studies: fixed-effects and random-effects methods" @default.
• W2909346791 cites W1523454857 @default.
• W2909346791 cites W1540596182 @default.
• W2909346791 cites W1716926924 @default.
• W2909346791 cites W1844405070 @default.
• W2909346791 cites W1928998639 @default.
• W2909346791 cites W1977104259 @default.
• W2909346791 cites W1978150238 @default.
• W2909346791 cites W1993849755 @default.
• W2909346791 cites W2009588715 @default.
• W2909346791 cites W2013274313 @default.
• W2909346791 cites W2024108088 @default.
• W2909346791 cites W2024290635 @default.
• W2909346791 cites W2025865441 @default.
• W2909346791 cites W2031090940 @default.
• W2909346791 cites W2031781568 @default.
• W2909346791 cites W2033151532 @default.
• W2909346791 cites W2080235308 @default.
• W2909346791 cites W2085783217 @default.
• W2909346791 cites W2088486634 @default.
• W2909346791 cites W2108169091 @default.
• W2909346791 cites W2115783720 @default.
• W2909346791 cites W2117446594 @default.
• W2909346791 cites W2119491313 @default.
• W2909346791 cites W2122161847 @default.
• W2909346791 cites W2127601863 @default.
• W2909346791 cites W2129559300 @default.
• W2909346791 cites W2130701931 @default.
• W2909346791 cites W2138668466 @default.
• W2909346791 cites W2141088880 @default.
• W2909346791 cites W2146415150 @default.
• W2909346791 cites W2153860431 @default.
• W2909346791 cites W2153968413 @default.
• W2909346791 cites W2155496693 @default.
• W2909346791 cites W2159417227 @default.
• W2909346791 cites W2161633633 @default.
• W2909346791 cites W2164492469 @default.
• W2909346791 cites W2188707104 @default.
• W2909346791 cites W2327983471 @default.
• W2909346791 cites W2531503851 @default.
• W2909346791 cites W2756182372 @default.
• W2909346791 cites W2765240591 @default.
• W2909346791 cites W2773459529 @default.
• W2909346791 cites W2809920685 @default.
• W2909346791 cites W2951217122 @default.
• W2909346791 cites W2952882474 @default.
• W2909346791 cites W2963159004 @default.
• W2909346791 cites W3104309687 @default.
• W2909346791 cites W2419045928 @default.
• W2909346791 doi "https://doi.org/10.48550/arxiv.1901.02936" @default.
• W2909346791 hasPublicationYear "2019" @default.
• W2909346791 type Work @default.
• W2909346791 sameAs 2909346791 @default.
• W2909346791 citedByCount "2" @default.
• W2909346791 countsByYear W29093467912019 @default.
• W2909346791 countsByYear W29093467912022 @default.
• W2909346791 crossrefType "posted-content" @default.
• W2909346791 hasAuthorship W2909346791A5011372682 @default.
• W2909346791 hasAuthorship W2909346791A5025052206 @default.
• W2909346791 hasBestOaLocation W29093467911 @default.
• W2909346791 hasConcept C104317684 @default.
• W2909346791 hasConcept C105795698 @default.
• W2909346791 hasConcept C106208931 @default.
• W2909346791 hasConcept C135763542 @default.
• W2909346791 hasConcept C153209595 @default.
• W2909346791 hasConcept C161890455 @default.
• W2909346791 hasConcept C186413461 @default.
• W2909346791 hasConcept C1921717 @default.
• W2909346791 hasConcept C33923547 @default.
• W2909346791 hasConcept C35605836 @default.
• W2909346791 hasConcept C54355233 @default.
• W2909346791 hasConcept C86803240 @default.
• W2909346791 hasConceptScore W2909346791C104317684 @default.
• W2909346791 hasConceptScore W2909346791C105795698 @default.
• W2909346791 hasConceptScore W2909346791C106208931 @default.
• W2909346791 hasConceptScore W2909346791C135763542 @default.
• W2909346791 hasConceptScore W2909346791C153209595 @default.
• W2909346791 hasConceptScore W2909346791C161890455 @default.
• W2909346791 hasConceptScore W2909346791C186413461 @default.
• W2909346791 hasConceptScore W2909346791C1921717 @default.
• W2909346791 hasConceptScore W2909346791C33923547 @default.
• W2909346791 hasConceptScore W2909346791C35605836 @default.
• W2909346791 hasConceptScore W2909346791C54355233 @default.
• W2909346791 hasConceptScore W2909346791C86803240 @default.
• W2909346791 hasLocation W29093467911 @default.
• W2909346791 hasOpenAccess W2909346791 @default.
• W2909346791 hasPrimaryLocation W29093467911 @default.
• W2909346791 hasRelatedWork W2033800025 @default.
• W2909346791 hasRelatedWork W2112153462 @default.
• W2909346791 hasRelatedWork W2469213152 @default.
• W2909346791 hasRelatedWork W2587963263 @default.
• W2909346791 hasRelatedWork W2769916609 @default.
• W2909346791 hasRelatedWork W2909346791 @default.
• W2909346791 hasRelatedWork W2941309982 @default.

• next