Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909369594> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2909369594 abstract "Background Saliva has been increasingly used as a diagnostic medium for disease detection and monitoring. Since saliva contains many of mediators of inflammation, collagen breakdown and/or bone remodelling, they may be of potential use for the rheumatic disease monitoring.1, 2 Objectives The aim of this pilot study was to investigate whether and how well salivary concentrations of CRP and IL-6 correlate with those in serum and with the clinical course of a rheumatic disease. Methods The nineteen consenting patients with rheumatoid arthritis or ankylosing spondylitis, newly scheduled for anti-TNFα therapy, were analysed. CRP and IL-6 were measured with high-sensitivity immunoassays before and after 12 weeks of anti-TNFα therapy, according to standard regimens. Disease activity and oral health parameters were also assessed. Results The patients’ baseline characteristics were summarised in Table 1. The treatment resulted in a significant improvement in the clinical status and standard biochemical parameters in the majority of patients (table 2). Concentrations of CRP in saliva correlated significantly with those in serum (R=0.62; p In contrast to CRP, the salivary concentrations of IL-6 did not change significantly over the course of therapy and they did not correlate with serum IL-6 concentrations. Salivary levels of neither CRP nor IL-6 corresponded to parameters of oral health and hygiene. Conclusions These data indicate, that salivary CRP but not IL-6 could be of potential use for monitoring the rheumatic disease activity. References [1] Buczko P, Zalewska A, Szarmach I. Saliva and oxidative stress in oral cavity and in some systemic disorders. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society. 2015;66(1):3–9. [2] Mirrielees J, Crofford LJ, Lin Y, Kryscio RJ, Dawson DR, 3rd, Ebersole JL, et al. Rheumatoid arthritis and salivary biomarkers of periodontal disease. Journal of clinical periodontology. 2010;37(12):1068–74. Disclosure of Interest None declared" @default.
- W2909369594 created "2019-01-25" @default.
- W2909369594 creator A5018328000 @default.
- W2909369594 creator A5034348366 @default.
- W2909369594 creator A5036061401 @default.
- W2909369594 creator A5048084644 @default.
- W2909369594 creator A5055184252 @default.
- W2909369594 creator A5057813655 @default.
- W2909369594 creator A5064367904 @default.
- W2909369594 creator A5071777615 @default.
- W2909369594 date "2018-06-01" @default.
- W2909369594 modified "2023-09-27" @default.
- W2909369594 title "AB1183 Diagnostic value of salivary crp and il-6 in patients undergoing anti-tnf-alpha therapy for rheumatic disease" @default.
- W2909369594 cites W1974635592 @default.
- W2909369594 doi "https://doi.org/10.1136/annrheumdis-2018-eular.1547" @default.
- W2909369594 hasPublicationYear "2018" @default.
- W2909369594 type Work @default.
- W2909369594 sameAs 2909369594 @default.
- W2909369594 citedByCount "0" @default.
- W2909369594 crossrefType "proceedings-article" @default.
- W2909369594 hasAuthorship W2909369594A5018328000 @default.
- W2909369594 hasAuthorship W2909369594A5034348366 @default.
- W2909369594 hasAuthorship W2909369594A5036061401 @default.
- W2909369594 hasAuthorship W2909369594A5048084644 @default.
- W2909369594 hasAuthorship W2909369594A5055184252 @default.
- W2909369594 hasAuthorship W2909369594A5057813655 @default.
- W2909369594 hasAuthorship W2909369594A5064367904 @default.
- W2909369594 hasAuthorship W2909369594A5071777615 @default.
- W2909369594 hasBestOaLocation W29093695941 @default.
- W2909369594 hasConcept C126322002 @default.
- W2909369594 hasConcept C203014093 @default.
- W2909369594 hasConcept C2776914184 @default.
- W2909369594 hasConcept C2777402515 @default.
- W2909369594 hasConcept C2777575956 @default.
- W2909369594 hasConcept C2779134260 @default.
- W2909369594 hasConcept C2781195455 @default.
- W2909369594 hasConcept C504460877 @default.
- W2909369594 hasConcept C71924100 @default.
- W2909369594 hasConcept C90924648 @default.
- W2909369594 hasConceptScore W2909369594C126322002 @default.
- W2909369594 hasConceptScore W2909369594C203014093 @default.
- W2909369594 hasConceptScore W2909369594C2776914184 @default.
- W2909369594 hasConceptScore W2909369594C2777402515 @default.
- W2909369594 hasConceptScore W2909369594C2777575956 @default.
- W2909369594 hasConceptScore W2909369594C2779134260 @default.
- W2909369594 hasConceptScore W2909369594C2781195455 @default.
- W2909369594 hasConceptScore W2909369594C504460877 @default.
- W2909369594 hasConceptScore W2909369594C71924100 @default.
- W2909369594 hasConceptScore W2909369594C90924648 @default.
- W2909369594 hasLocation W29093695941 @default.
- W2909369594 hasOpenAccess W2909369594 @default.
- W2909369594 hasPrimaryLocation W29093695941 @default.
- W2909369594 hasRelatedWork W117333056 @default.
- W2909369594 hasRelatedWork W2028014480 @default.
- W2909369594 hasRelatedWork W2043046430 @default.
- W2909369594 hasRelatedWork W2156854524 @default.
- W2909369594 hasRelatedWork W2278092689 @default.
- W2909369594 hasRelatedWork W2347690830 @default.
- W2909369594 hasRelatedWork W2362085021 @default.
- W2909369594 hasRelatedWork W2366079010 @default.
- W2909369594 hasRelatedWork W2391281933 @default.
- W2909369594 hasRelatedWork W2392787759 @default.
- W2909369594 hasRelatedWork W2403820736 @default.
- W2909369594 hasRelatedWork W2415115520 @default.
- W2909369594 hasRelatedWork W2883908810 @default.
- W2909369594 hasRelatedWork W2999425805 @default.
- W2909369594 hasRelatedWork W3009110030 @default.
- W2909369594 hasRelatedWork W3030985163 @default.
- W2909369594 hasRelatedWork W3043344104 @default.
- W2909369594 hasRelatedWork W3088903648 @default.
- W2909369594 hasRelatedWork W3095287419 @default.
- W2909369594 hasRelatedWork W3203832015 @default.
- W2909369594 isParatext "false" @default.
- W2909369594 isRetracted "false" @default.
- W2909369594 magId "2909369594" @default.
- W2909369594 workType "article" @default.