Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909391765> ?p ?o ?g. }
- W2909391765 endingPage "467" @default.
- W2909391765 startingPage "453" @default.
- W2909391765 abstract "Gram-negative bacteria produce repeats-in-toxin adhesion proteins (RTX adhesins) to facilitate microbial adhesion. These large, multidomain proteins share a common architecture comprised of four regions. First to emerge from the bacterium, C terminal end leading, is the RTX export sequence that directs the protein through the type 1 secretion system (T1SS). This is followed by the ligand-binding region responsible for host adhesion and cohesion, which contains diverse ligand-binding domains. These serve a zip code function to direct bacteria to a particular environmental niche. Thereafter is a large extension region consisting of tens to hundreds of tandem bacterial immunoglobulin-like (BIg) domains, whose function is to extend the reach of the ligand-binding domains away from the bacterial surface. Lastly, there is a conserved N terminal cell-membrane-anchor region that retains the adhesin within the secretion system. This is also a site of in situ proteolysis, when nutrients are scarce, that enables the bacterium to leave the biofilm. In this review, the four regions of RTX adhesins are presented in the order in which they emerge from the cell during synthesis and retention." @default.
- W2909391765 created "2019-01-25" @default.
- W2909391765 creator A5035023245 @default.
- W2909391765 creator A5053398244 @default.
- W2909391765 creator A5064110980 @default.
- W2909391765 creator A5068131128 @default.
- W2909391765 creator A5090432905 @default.
- W2909391765 date "2019-05-01" @default.
- W2909391765 modified "2023-10-03" @default.
- W2909391765 title "RTX Adhesins are Key Bacterial Surface Megaproteins in the Formation of Biofilms" @default.
- W2909391765 cites W1597703864 @default.
- W2909391765 cites W1634254630 @default.
- W2909391765 cites W1751810238 @default.
- W2909391765 cites W1868155459 @default.
- W2909391765 cites W1892148740 @default.
- W2909391765 cites W1932043986 @default.
- W2909391765 cites W1967799249 @default.
- W2909391765 cites W1969641905 @default.
- W2909391765 cites W1971008206 @default.
- W2909391765 cites W1980733427 @default.
- W2909391765 cites W1981284849 @default.
- W2909391765 cites W1983029663 @default.
- W2909391765 cites W1983203321 @default.
- W2909391765 cites W1984699600 @default.
- W2909391765 cites W1985726492 @default.
- W2909391765 cites W1992764122 @default.
- W2909391765 cites W2003111769 @default.
- W2909391765 cites W2008892404 @default.
- W2909391765 cites W2015148410 @default.
- W2909391765 cites W2016388018 @default.
- W2909391765 cites W2019346760 @default.
- W2909391765 cites W2021242777 @default.
- W2909391765 cites W2029662163 @default.
- W2909391765 cites W2033318853 @default.
- W2909391765 cites W2034870531 @default.
- W2909391765 cites W2037720334 @default.
- W2909391765 cites W2038718832 @default.
- W2909391765 cites W2039095273 @default.
- W2909391765 cites W2052618033 @default.
- W2909391765 cites W2057593710 @default.
- W2909391765 cites W2059933240 @default.
- W2909391765 cites W2061856372 @default.
- W2909391765 cites W2063563910 @default.
- W2909391765 cites W2069513962 @default.
- W2909391765 cites W2071119634 @default.
- W2909391765 cites W2071316880 @default.
- W2909391765 cites W2078093751 @default.
- W2909391765 cites W2085877599 @default.
- W2909391765 cites W2086871274 @default.
- W2909391765 cites W2087646013 @default.
- W2909391765 cites W2087765833 @default.
- W2909391765 cites W2089625435 @default.
- W2909391765 cites W2090026561 @default.
- W2909391765 cites W2096068443 @default.
- W2909391765 cites W2096728209 @default.
- W2909391765 cites W2100239296 @default.
- W2909391765 cites W2105614327 @default.
- W2909391765 cites W2109532360 @default.
- W2909391765 cites W2109764663 @default.
- W2909391765 cites W2112313101 @default.
- W2909391765 cites W2115956404 @default.
- W2909391765 cites W2122374369 @default.
- W2909391765 cites W2135838357 @default.
- W2909391765 cites W2137827663 @default.
- W2909391765 cites W2139411571 @default.
- W2909391765 cites W2150187215 @default.
- W2909391765 cites W2156114650 @default.
- W2909391765 cites W2159942570 @default.
- W2909391765 cites W2164461702 @default.
- W2909391765 cites W2167556437 @default.
- W2909391765 cites W2172154503 @default.
- W2909391765 cites W2176048240 @default.
- W2909391765 cites W2264747822 @default.
- W2909391765 cites W2275145293 @default.
- W2909391765 cites W2308145610 @default.
- W2909391765 cites W2312277996 @default.
- W2909391765 cites W2329066638 @default.
- W2909391765 cites W2516793494 @default.
- W2909391765 cites W2530065612 @default.
- W2909391765 cites W2584603648 @default.
- W2909391765 cites W2595396785 @default.
- W2909391765 cites W2616670538 @default.
- W2909391765 cites W2625600655 @default.
- W2909391765 cites W2724541800 @default.
- W2909391765 cites W2742643337 @default.
- W2909391765 cites W2753008390 @default.
- W2909391765 cites W2771042176 @default.
- W2909391765 cites W2790549124 @default.
- W2909391765 cites W2791375079 @default.
- W2909391765 cites W2792963933 @default.
- W2909391765 cites W2806695756 @default.
- W2909391765 cites W3189920043 @default.
- W2909391765 cites W846736334 @default.
- W2909391765 cites W942112336 @default.
- W2909391765 doi "https://doi.org/10.1016/j.tim.2018.12.003" @default.
- W2909391765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30826181" @default.
- W2909391765 hasPublicationYear "2019" @default.
- W2909391765 type Work @default.