FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909395860> ?p ?o ?g. }

• W2909395860 endingPage "e0210010" @default.
• W2909395860 startingPage "e0210010" @default.
• W2909395860 abstract "Background The health economic evidence about the value and optimal targeting of genetic testing in the prevention of coronary heart disease (CHD) events has remained limited and ambiguous. The objective of this study is to optimize the population-level use and targeting of genetic testing alongside traditional risk factors in the prevention of CHD events and, thereby, to assess the cost-benefit of genetic testing. Methods and findings We compare several strategies for using traditional and genetic testing in the prevention of CHD through statin therapy. The targeting of tests to different patient segments within these strategies is optimized by using a decision-analytic model, in which a patient’s estimated risk of CHD is updated based on test results using Bayesian methods. We adopt the perspective of healthcare sector. The data for the model is exceptionally wide and combined from national healthcare registers, the Finnish Institute for Molecular Medicine, and published literature. Our results suggest that targeting genetic testing in an optimal way to those patients about which traditional risk factors do not provide sufficiently accurate information results in the highest expected net benefit. In particular, compared to the use of traditional risk factors only, the optimal use of genetic testing would decrease the expected costs of an average patient aged 45 years or more by 2.54€ in a 10-year follow-up period while maintaining the level of the expected health outcome. Thus, genetic testing is found to be a part of a cost-beneficial testing strategy alongside traditional risk factors. This conclusion is robust to reasonable changes in model inputs. Conclusions If targeted optimally, the use of genetic testing alongside traditional risk factors is cost-beneficial in the prevention of CHD." @default.
• W2909395860 created "2019-01-25" @default.
• W2909395860 creator A5034908428 @default.
• W2909395860 creator A5041790974 @default.
• W2909395860 creator A5067279132 @default.
• W2909395860 date "2019-01-15" @default.
• W2909395860 modified "2023-10-16" @default.
• W2909395860 title "Value of genetic testing in the prevention of coronary heart disease events" @default.
• W2909395860 cites W1850795643 @default.
• W2909395860 cites W1970729612 @default.
• W2909395860 cites W1988195069 @default.
• W2909395860 cites W2031968478 @default.
• W2909395860 cites W2041793361 @default.
• W2909395860 cites W2042681215 @default.
• W2909395860 cites W2050484525 @default.
• W2909395860 cites W2051018882 @default.
• W2909395860 cites W2058056848 @default.
• W2909395860 cites W2062787238 @default.
• W2909395860 cites W2066157763 @default.
• W2909395860 cites W2097713945 @default.
• W2909395860 cites W2107356770 @default.
• W2909395860 cites W2135313485 @default.
• W2909395860 cites W2137249087 @default.
• W2909395860 cites W2142140912 @default.
• W2909395860 cites W2161276171 @default.
• W2909395860 cites W2165670510 @default.
• W2909395860 cites W2165884492 @default.
• W2909395860 cites W2168528355 @default.
• W2909395860 cites W2168973485 @default.
• W2909395860 cites W2521147375 @default.
• W2909395860 cites W2796769706 @default.
• W2909395860 cites W2886752110 @default.
• W2909395860 doi "https://doi.org/10.1371/journal.pone.0210010" @default.
• W2909395860 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6333335" @default.
• W2909395860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30645616" @default.
• W2909395860 hasPublicationYear "2019" @default.
• W2909395860 type Work @default.
• W2909395860 sameAs 2909395860 @default.
• W2909395860 citedByCount "16" @default.
• W2909395860 countsByYear W29093958602019 @default.
• W2909395860 countsByYear W29093958602020 @default.
• W2909395860 countsByYear W29093958602021 @default.
• W2909395860 countsByYear W29093958602022 @default.
• W2909395860 countsByYear W29093958602023 @default.
• W2909395860 crossrefType "journal-article" @default.
• W2909395860 hasAuthorship W2909395860A5034908428 @default.
• W2909395860 hasAuthorship W2909395860A5041790974 @default.
• W2909395860 hasAuthorship W2909395860A5067279132 @default.
• W2909395860 hasBestOaLocation W29093958601 @default.
• W2909395860 hasConcept C12174686 @default.
• W2909395860 hasConcept C126322002 @default.
• W2909395860 hasConcept C160735492 @default.
• W2909395860 hasConcept C162324750 @default.
• W2909395860 hasConcept C177713679 @default.
• W2909395860 hasConcept C2779134260 @default.
• W2909395860 hasConcept C2780673598 @default.
• W2909395860 hasConcept C2908647359 @default.
• W2909395860 hasConcept C32220436 @default.
• W2909395860 hasConcept C38652104 @default.
• W2909395860 hasConcept C41008148 @default.
• W2909395860 hasConcept C50522688 @default.
• W2909395860 hasConcept C60644358 @default.
• W2909395860 hasConcept C71924100 @default.
• W2909395860 hasConcept C86803240 @default.
• W2909395860 hasConcept C99454951 @default.
• W2909395860 hasConceptScore W2909395860C12174686 @default.
• W2909395860 hasConceptScore W2909395860C126322002 @default.
• W2909395860 hasConceptScore W2909395860C160735492 @default.
• W2909395860 hasConceptScore W2909395860C162324750 @default.
• W2909395860 hasConceptScore W2909395860C177713679 @default.
• W2909395860 hasConceptScore W2909395860C2779134260 @default.
• W2909395860 hasConceptScore W2909395860C2780673598 @default.
• W2909395860 hasConceptScore W2909395860C2908647359 @default.
• W2909395860 hasConceptScore W2909395860C32220436 @default.
• W2909395860 hasConceptScore W2909395860C38652104 @default.
• W2909395860 hasConceptScore W2909395860C41008148 @default.
• W2909395860 hasConceptScore W2909395860C50522688 @default.
• W2909395860 hasConceptScore W2909395860C60644358 @default.
• W2909395860 hasConceptScore W2909395860C71924100 @default.
• W2909395860 hasConceptScore W2909395860C86803240 @default.
• W2909395860 hasConceptScore W2909395860C99454951 @default.
• W2909395860 hasFunder F4320321855 @default.
• W2909395860 hasIssue "1" @default.
• W2909395860 hasLocation W29093958601 @default.
• W2909395860 hasLocation W29093958602 @default.
• W2909395860 hasLocation W29093958603 @default.
• W2909395860 hasLocation W29093958604 @default.
• W2909395860 hasLocation W29093958605 @default.
• W2909395860 hasOpenAccess W2909395860 @default.
• W2909395860 hasPrimaryLocation W29093958601 @default.
• W2909395860 hasRelatedWork W2008333285 @default.
• W2909395860 hasRelatedWork W2192968700 @default.
• W2909395860 hasRelatedWork W2333657843 @default.
• W2909395860 hasRelatedWork W2531653299 @default.
• W2909395860 hasRelatedWork W2896996832 @default.
• W2909395860 hasRelatedWork W2983979507 @default.
• W2909395860 hasRelatedWork W343696274 @default.
• W2909395860 hasRelatedWork W4226103442 @default.

• next