FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909435470> ?p ?o ?g. }

• W2909435470 endingPage "69" @default.
• W2909435470 startingPage "69" @default.
• W2909435470 abstract "Approximately 30% of traumatic brain injured patients suffer from acute lung injury or acute respiratory distress syndrome. Our previous work revealed that extracellular vesicle (EV)-mediated inflammasome signaling plays a crucial role in the pathophysiology of traumatic brain injury (TBI)-induced lung injury. Here, serum-derived EVs from severe TBI patients were analyzed for particle size, concentration, origin, and levels of the inflammasome component, an apoptosis-associated speck-like protein containing a caspase-recruiting domain (ASC). Serum ASC levels were analyzed from EV obtained from patients that presented lung injury after TBI and compared them to EV obtained from patients that did not show any signs of lung injury. EVs were co-cultured with lung human microvascular endothelial cells (HMVEC-L) to evaluate inflammasome activation and endothelial cell pyroptosis. TBI patients had a significant increase in the number of serum-derived EVs and levels of ASC. Severe TBI patients with lung injury had a significantly higher level of ASC in serum and serum-derived EVs compared to individuals without lung injury. Only EVs isolated from head trauma patients with gunshot wounds were of neural origin. Delivery of serum-derived EVs to HMVEC-L activated the inflammasome and resulted in endothelial cell pyroptosis. Thus, serum-derived EVs and inflammasome proteins play a critical role in the pathogenesis of TBI-induced lung injury, supporting activation of an EV-mediated neural-respiratory inflammasome axis in TBI-induced lung injury." @default.
• W2909435470 created "2019-01-25" @default.
• W2909435470 creator A5002808336 @default.
• W2909435470 creator A5006282421 @default.
• W2909435470 creator A5007874880 @default.
• W2909435470 creator A5045688399 @default.
• W2909435470 creator A5047236443 @default.
• W2909435470 creator A5063816770 @default.
• W2909435470 creator A5075604861 @default.
• W2909435470 date "2019-01-18" @default.
• W2909435470 modified "2023-10-11" @default.
• W2909435470 title "Human Lung Cell Pyroptosis Following Traumatic Brain Injury" @default.
• W2909435470 cites W1144427699 @default.
• W2909435470 cites W1587711235 @default.
• W2909435470 cites W1705803987 @default.
• W2909435470 cites W1864325817 @default.
• W2909435470 cites W1948084312 @default.
• W2909435470 cites W1990934962 @default.
• W2909435470 cites W2006035377 @default.
• W2909435470 cites W2032370476 @default.
• W2909435470 cites W2095916445 @default.
• W2909435470 cites W2111560326 @default.
• W2909435470 cites W2127761382 @default.
• W2909435470 cites W2148050305 @default.
• W2909435470 cites W2154439780 @default.
• W2909435470 cites W2159401023 @default.
• W2909435470 cites W2167505713 @default.
• W2909435470 cites W2288512038 @default.
• W2909435470 cites W2332249743 @default.
• W2909435470 cites W2341322661 @default.
• W2909435470 cites W2397416734 @default.
• W2909435470 cites W2509404535 @default.
• W2909435470 cites W2510919342 @default.
• W2909435470 cites W2530347235 @default.
• W2909435470 cites W2538561584 @default.
• W2909435470 cites W2592524105 @default.
• W2909435470 cites W2609301549 @default.
• W2909435470 cites W2618630926 @default.
• W2909435470 cites W2734712906 @default.
• W2909435470 cites W2736321686 @default.
• W2909435470 cites W2763425528 @default.
• W2909435470 cites W2764244969 @default.
• W2909435470 cites W2769100785 @default.
• W2909435470 cites W2770373190 @default.
• W2909435470 cites W2782167051 @default.
• W2909435470 cites W2783823932 @default.
• W2909435470 cites W2790182712 @default.
• W2909435470 cites W2794855561 @default.
• W2909435470 doi "https://doi.org/10.3390/cells8010069" @default.
• W2909435470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6356886" @default.
• W2909435470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30669285" @default.
• W2909435470 hasPublicationYear "2019" @default.
• W2909435470 type Work @default.
• W2909435470 sameAs 2909435470 @default.
• W2909435470 citedByCount "37" @default.
• W2909435470 countsByYear W29094354702019 @default.
• W2909435470 countsByYear W29094354702020 @default.
• W2909435470 countsByYear W29094354702021 @default.
• W2909435470 countsByYear W29094354702022 @default.
• W2909435470 countsByYear W29094354702023 @default.
• W2909435470 crossrefType "journal-article" @default.
• W2909435470 hasAuthorship W2909435470A5002808336 @default.
• W2909435470 hasAuthorship W2909435470A5006282421 @default.
• W2909435470 hasAuthorship W2909435470A5007874880 @default.
• W2909435470 hasAuthorship W2909435470A5045688399 @default.
• W2909435470 hasAuthorship W2909435470A5047236443 @default.
• W2909435470 hasAuthorship W2909435470A5063816770 @default.
• W2909435470 hasAuthorship W2909435470A5075604861 @default.
• W2909435470 hasBestOaLocation W29094354701 @default.
• W2909435470 hasConcept C118552586 @default.
• W2909435470 hasConcept C126322002 @default.
• W2909435470 hasConcept C17172800 @default.
• W2909435470 hasConcept C203014093 @default.
• W2909435470 hasConcept C2776348555 @default.
• W2909435470 hasConcept C2776914184 @default.
• W2909435470 hasConcept C2777209026 @default.
• W2909435470 hasConcept C2777714996 @default.
• W2909435470 hasConcept C2780942790 @default.
• W2909435470 hasConcept C2781017439 @default.
• W2909435470 hasConcept C71924100 @default.
• W2909435470 hasConceptScore W2909435470C118552586 @default.
• W2909435470 hasConceptScore W2909435470C126322002 @default.
• W2909435470 hasConceptScore W2909435470C17172800 @default.
• W2909435470 hasConceptScore W2909435470C203014093 @default.
• W2909435470 hasConceptScore W2909435470C2776348555 @default.
• W2909435470 hasConceptScore W2909435470C2776914184 @default.
• W2909435470 hasConceptScore W2909435470C2777209026 @default.
• W2909435470 hasConceptScore W2909435470C2777714996 @default.
• W2909435470 hasConceptScore W2909435470C2780942790 @default.
• W2909435470 hasConceptScore W2909435470C2781017439 @default.
• W2909435470 hasConceptScore W2909435470C71924100 @default.
• W2909435470 hasFunder F4320306080 @default.
• W2909435470 hasIssue "1" @default.
• W2909435470 hasLocation W29094354701 @default.
• W2909435470 hasLocation W29094354702 @default.
• W2909435470 hasLocation W29094354703 @default.
• W2909435470 hasOpenAccess W2909435470 @default.
• W2909435470 hasPrimaryLocation W29094354701 @default.

• next