Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909438384> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2909438384 endingPage "2320" @default.
- W2909438384 startingPage "2313" @default.
- W2909438384 abstract "Objective To determine the optimal sequencing of chemoradiotherapy for locally advanced laryngeal cancer. The hypothesis was that concurrent chemoradiotherapy (CCRT) would be associated with improved overall survival (OS) compared to induction chemotherapy followed by radiotherapy (RT)/surgery (IC). Methods The National Cancer Database identified 8,154 patients with American Joint Commission on Cancer stage III/IV (excluding T1) laryngeal cancer between 2004 and 2013 treated with one of the established organ preservation techniques: CCRT or IC. The association between OS and total radiation dose (< 66 gray [Gy] or ≥ 66 Gy) was analyzed using the Kaplan‐Meier method, as was the association between OS and timing of IC (21–42, 43–100, or 101–120 days before RT). Hazard ratios (HR) adjusted for patient and clinical characteristics were computed using Cox regression modeling. Results The median follow‐up was 32.7 months. The estimated 5‐year OS for CCRT and IC was 49.9% and 50.6%, respectively ( P = 0.653). On multivariate analysis, no difference was observed between the two regimens (IC, adjusted HR 0.96, 95% confidence interval [CI] 0.88–1.04, P = 0.268). Radiation dose ≥66 Gy had improved OS overall in CCRT group but not in IC patients. When comparing CCRT and IC in patients receiving ≥66 Gy, there was no difference in OS (adjusted HR 0.97, 95% CI 0.89–1.06, P = 0.552). Patients starting chemotherapy 21 to 42 or 101 to 120 days prior to RT had inferior OS compared to patients starting between 43 to 100 days. Conclusion For locally advanced laryngeal cancer, there is no difference in OS between CCRT and IC. Factors associated with survival included radiation dose and timing of induction chemotherapy before RT. Level of Evidence 3b Laryngoscope , 129:2313–2320, 2019" @default.
- W2909438384 created "2019-01-25" @default.
- W2909438384 creator A5008502473 @default.
- W2909438384 creator A5023634801 @default.
- W2909438384 creator A5025615934 @default.
- W2909438384 creator A5033522645 @default.
- W2909438384 creator A5060086464 @default.
- W2909438384 creator A5068170177 @default.
- W2909438384 creator A5074948841 @default.
- W2909438384 creator A5077699448 @default.
- W2909438384 creator A5083872810 @default.
- W2909438384 date "2019-01-09" @default.
- W2909438384 modified "2023-10-12" @default.
- W2909438384 title "Optimal sequencing of chemoradiotherapy for locally advanced laryngeal cancer" @default.
- W2909438384 cites W1983970003 @default.
- W2909438384 cites W1992321269 @default.
- W2909438384 cites W2000219306 @default.
- W2909438384 cites W2045248401 @default.
- W2909438384 cites W2046966760 @default.
- W2909438384 cites W2100961085 @default.
- W2909438384 cites W2106288330 @default.
- W2909438384 cites W2118938219 @default.
- W2909438384 cites W2140753782 @default.
- W2909438384 cites W2141592118 @default.
- W2909438384 cites W2166349420 @default.
- W2909438384 cites W2562414697 @default.
- W2909438384 cites W2605479267 @default.
- W2909438384 doi "https://doi.org/10.1002/lary.27771" @default.
- W2909438384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30628077" @default.
- W2909438384 hasPublicationYear "2019" @default.
- W2909438384 type Work @default.
- W2909438384 sameAs 2909438384 @default.
- W2909438384 citedByCount "1" @default.
- W2909438384 countsByYear W29094383842022 @default.
- W2909438384 crossrefType "journal-article" @default.
- W2909438384 hasAuthorship W2909438384A5008502473 @default.
- W2909438384 hasAuthorship W2909438384A5023634801 @default.
- W2909438384 hasAuthorship W2909438384A5025615934 @default.
- W2909438384 hasAuthorship W2909438384A5033522645 @default.
- W2909438384 hasAuthorship W2909438384A5060086464 @default.
- W2909438384 hasAuthorship W2909438384A5068170177 @default.
- W2909438384 hasAuthorship W2909438384A5074948841 @default.
- W2909438384 hasAuthorship W2909438384A5077699448 @default.
- W2909438384 hasAuthorship W2909438384A5083872810 @default.
- W2909438384 hasConcept C121608353 @default.
- W2909438384 hasConcept C126322002 @default.
- W2909438384 hasConcept C141071460 @default.
- W2909438384 hasConcept C143998085 @default.
- W2909438384 hasConcept C146357865 @default.
- W2909438384 hasConcept C151730666 @default.
- W2909438384 hasConcept C207103383 @default.
- W2909438384 hasConcept C2776256026 @default.
- W2909438384 hasConcept C2776694085 @default.
- W2909438384 hasConcept C2778424827 @default.
- W2909438384 hasConcept C44249647 @default.
- W2909438384 hasConcept C50382708 @default.
- W2909438384 hasConcept C509974204 @default.
- W2909438384 hasConcept C71924100 @default.
- W2909438384 hasConcept C86803240 @default.
- W2909438384 hasConceptScore W2909438384C121608353 @default.
- W2909438384 hasConceptScore W2909438384C126322002 @default.
- W2909438384 hasConceptScore W2909438384C141071460 @default.
- W2909438384 hasConceptScore W2909438384C143998085 @default.
- W2909438384 hasConceptScore W2909438384C146357865 @default.
- W2909438384 hasConceptScore W2909438384C151730666 @default.
- W2909438384 hasConceptScore W2909438384C207103383 @default.
- W2909438384 hasConceptScore W2909438384C2776256026 @default.
- W2909438384 hasConceptScore W2909438384C2776694085 @default.
- W2909438384 hasConceptScore W2909438384C2778424827 @default.
- W2909438384 hasConceptScore W2909438384C44249647 @default.
- W2909438384 hasConceptScore W2909438384C50382708 @default.
- W2909438384 hasConceptScore W2909438384C509974204 @default.
- W2909438384 hasConceptScore W2909438384C71924100 @default.
- W2909438384 hasConceptScore W2909438384C86803240 @default.
- W2909438384 hasIssue "10" @default.
- W2909438384 hasLocation W29094383841 @default.
- W2909438384 hasLocation W29094383842 @default.
- W2909438384 hasOpenAccess W2909438384 @default.
- W2909438384 hasPrimaryLocation W29094383841 @default.
- W2909438384 hasRelatedWork W2119154902 @default.
- W2909438384 hasRelatedWork W2133235702 @default.
- W2909438384 hasRelatedWork W2203903734 @default.
- W2909438384 hasRelatedWork W2277416945 @default.
- W2909438384 hasRelatedWork W2357406576 @default.
- W2909438384 hasRelatedWork W2404042595 @default.
- W2909438384 hasRelatedWork W2556093218 @default.
- W2909438384 hasRelatedWork W2917746345 @default.
- W2909438384 hasRelatedWork W4382279650 @default.
- W2909438384 hasRelatedWork W1899415052 @default.
- W2909438384 hasVolume "129" @default.
- W2909438384 isParatext "false" @default.
- W2909438384 isRetracted "false" @default.
- W2909438384 magId "2909438384" @default.
- W2909438384 workType "article" @default.