Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909533094> ?p ?o ?g. }
- W2909533094 endingPage "91" @default.
- W2909533094 startingPage "77" @default.
- W2909533094 abstract "Recent studies revealed that pharmacological modulation of NAE-hydrolyzing acid amidase (NAAA) can be achieved with PEA oxazoline (PEA-OXA). Hence, the aim of the present work was to thoroughly evaluate the anti-inflammatory and neuroprotective effects of PEA-OXA in an experimental model of vascular dementia (VaD) induced by bilateral carotid arteries occlusion. At 24 h after VaD induction, animals were orally administered with 10 mg/kg of PEA-OXA daily for 15 days.Brain tissues were handled for histological, immunohistochemical, western blot, and immunofluorescence analysis. PEA-OXA treatment evidently reduced the histological alterations and neuronal death induced by VaD and additionally improved behavioral deficits. Further, PEA-OXA decreased GFAP and Iba-1, markers of astrocytes, and microglia activation, as well as increased MAP-2, a marker of neuron development. Moreover, PEA-OXA reduced oxidative stress, modulated Nrf2-mediated antioxidant response, and inhibited the apoptotic process.Some drugs may demonstrate their healing potential by regulating neuroinflammation, rather than by their habitually attributed actions only. Palmitoylethanolamide (PEA) is a prototype ALIAmide, well-known for its analgesic, anti-inflammatory, and neuroprotective properties. The inhibition of PEA degradation by targeting NAAA, its catabolic enzyme, is a different approach for treating neuroinflammation. This research offers new insight into the mechanism of PEA-OXA-induced neuroprotection.Thus, the modulation of intracellular NAAA by PEA-OXA could offer a novel means of controlling neuroinflammatory conditions associated with VaD." @default.
- W2909533094 created "2019-01-25" @default.
- W2909533094 creator A5005277928 @default.
- W2909533094 creator A5012495688 @default.
- W2909533094 creator A5022376648 @default.
- W2909533094 creator A5027732860 @default.
- W2909533094 creator A5049935256 @default.
- W2909533094 creator A5052387572 @default.
- W2909533094 creator A5053839749 @default.
- W2909533094 creator A5067672486 @default.
- W2909533094 creator A5076323717 @default.
- W2909533094 creator A5086038807 @default.
- W2909533094 creator A5087999529 @default.
- W2909533094 date "2019-05-01" @default.
- W2909533094 modified "2023-10-10" @default.
- W2909533094 title "N-Palmitoylethanolamine-oxazoline (PEA-OXA): A new therapeutic strategy to reduce neuroinflammation, oxidative stress associated to vascular dementia in an experimental model of repeated bilateral common carotid arteries occlusion" @default.
- W2909533094 cites W1515390664 @default.
- W2909533094 cites W1564854503 @default.
- W2909533094 cites W1590514634 @default.
- W2909533094 cites W1601296623 @default.
- W2909533094 cites W1965286814 @default.
- W2909533094 cites W1968671323 @default.
- W2909533094 cites W1969974084 @default.
- W2909533094 cites W1971701992 @default.
- W2909533094 cites W1982291289 @default.
- W2909533094 cites W1988883987 @default.
- W2909533094 cites W1989867219 @default.
- W2909533094 cites W1994099277 @default.
- W2909533094 cites W1998734250 @default.
- W2909533094 cites W1999881028 @default.
- W2909533094 cites W2003110967 @default.
- W2909533094 cites W2004449360 @default.
- W2909533094 cites W2007373797 @default.
- W2909533094 cites W2009643179 @default.
- W2909533094 cites W2010746507 @default.
- W2909533094 cites W2013744734 @default.
- W2909533094 cites W2017733129 @default.
- W2909533094 cites W2021337250 @default.
- W2909533094 cites W2028520672 @default.
- W2909533094 cites W2028911700 @default.
- W2909533094 cites W2028998846 @default.
- W2909533094 cites W2048918162 @default.
- W2909533094 cites W2056416370 @default.
- W2909533094 cites W2066788206 @default.
- W2909533094 cites W2069800127 @default.
- W2909533094 cites W2074601245 @default.
- W2909533094 cites W2084616822 @default.
- W2909533094 cites W2084644507 @default.
- W2909533094 cites W2090660376 @default.
- W2909533094 cites W2093800305 @default.
- W2909533094 cites W2095720174 @default.
- W2909533094 cites W2096261918 @default.
- W2909533094 cites W2109877470 @default.
- W2909533094 cites W2114113470 @default.
- W2909533094 cites W2118830011 @default.
- W2909533094 cites W2124779892 @default.
- W2909533094 cites W2125410210 @default.
- W2909533094 cites W2130975342 @default.
- W2909533094 cites W2150503227 @default.
- W2909533094 cites W2159155070 @default.
- W2909533094 cites W2163214197 @default.
- W2909533094 cites W2187458946 @default.
- W2909533094 cites W2325852107 @default.
- W2909533094 cites W2340147290 @default.
- W2909533094 cites W2342165381 @default.
- W2909533094 cites W2345838873 @default.
- W2909533094 cites W2405727557 @default.
- W2909533094 cites W2500109500 @default.
- W2909533094 cites W2579015254 @default.
- W2909533094 cites W2607610086 @default.
- W2909533094 cites W2617413767 @default.
- W2909533094 cites W2623165218 @default.
- W2909533094 cites W2623874973 @default.
- W2909533094 cites W2738181020 @default.
- W2909533094 cites W2759589557 @default.
- W2909533094 cites W2761784268 @default.
- W2909533094 cites W2797560790 @default.
- W2909533094 cites W586224869 @default.
- W2909533094 doi "https://doi.org/10.1016/j.nbd.2019.01.007" @default.
- W2909533094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30660740" @default.
- W2909533094 hasPublicationYear "2019" @default.
- W2909533094 type Work @default.
- W2909533094 sameAs 2909533094 @default.
- W2909533094 citedByCount "52" @default.
- W2909533094 countsByYear W29095330942019 @default.
- W2909533094 countsByYear W29095330942020 @default.
- W2909533094 countsByYear W29095330942021 @default.
- W2909533094 countsByYear W29095330942022 @default.
- W2909533094 countsByYear W29095330942023 @default.
- W2909533094 crossrefType "journal-article" @default.
- W2909533094 hasAuthorship W2909533094A5005277928 @default.
- W2909533094 hasAuthorship W2909533094A5012495688 @default.
- W2909533094 hasAuthorship W2909533094A5022376648 @default.
- W2909533094 hasAuthorship W2909533094A5027732860 @default.
- W2909533094 hasAuthorship W2909533094A5049935256 @default.
- W2909533094 hasAuthorship W2909533094A5052387572 @default.
- W2909533094 hasAuthorship W2909533094A5053839749 @default.
- W2909533094 hasAuthorship W2909533094A5067672486 @default.