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- W2909552025 endingPage "1680" @default.
- W2909552025 startingPage "1667" @default.
- W2909552025 abstract "Prodigiosin, a red linear tripyrrole pigment and a member of the prodiginine family, is normally secreted by the human pathogen Serratia marcescens as a secondary metabolite. Studies on prodigiosin have received renewed attention as a result of reported immunosuppressive, antimicrobial and anticancer properties. High-level synthesis of prodigiosin and the bioengineering of strains to synthesise useful prodiginine derivatives have also been a subject of investigation. To exploit the potential use of prodigiosin as a clinical drug targeting bacteria or as a dye for textiles, high-level synthesis of prodigiosin is a prerequisite. This review presents an overview on the biosynthesis of prodigiosin from its natural host Serratia marcescens and through recombinant approaches as well as highlighting the beneficial properties of prodigiosin. We also discuss the prospect of adopting a synthetic biology approach for safe and cost-effective production of prodigiosin in a more industrially compliant surrogate host." @default.
- W2909552025 created "2019-01-25" @default.
- W2909552025 creator A5007974324 @default.
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- W2909552025 creator A5069492419 @default.
- W2909552025 creator A5071759936 @default.
- W2909552025 creator A5083764222 @default.
- W2909552025 date "2019-01-12" @default.
- W2909552025 modified "2023-10-10" @default.
- W2909552025 title "Recent advancements in high-level synthesis of the promising clinical drug, prodigiosin" @default.
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