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- W2909558076 abstract "Thyroid cancers developed from the tissues of the thyroid gland are classified into papillary (PTC), follicular (FTC), medullary (MTC), and anaplastic thyroid cancer (ATC). Although thyroid cancers have been generally known as mild forms of cancer, undifferentiated MTC and ATC have a more unfavorable prognosis than differentiated PTC and FTC because they are more aggressive and early metastatic. A variety of therapies such as surgery, radiotherapy, and chemotherapy have been currently used to treat thyroid cancer, but they still have limitations including drug resistance or unfavorable side effects. Phytochemicals are plant-derived chemicals having various physiological activities that are expected to be effective in cancer treatment. In this review, anticancer efficacy of phytochemicals, such as resveratrol, genistein, curcumin, and other substances in each type of thyroid cancer was introduced with their chemopreventive mechanisms. English articles related with thyroid cancer and anti-thyroid cancer of phytochemicals were searched from PubMed and Google Scholar. This article mainly focused on in vitro or animal studies on phytochemicals with anti-thyroid cancer activity. These various phytochemicals have been shown to induce apoptosis in all types of thyroid cancer cells, inhibit cell proliferation and invasion, and to be helpful in enhancing the effect of radioiodine therapy that is a typical therapy to thyroid cancer. These results suggest that thyroid cancer can be more effectively treated by the combinations of phytochemicals and the existing therapies or substances." @default.
- W2909558076 created "2019-01-25" @default.
- W2909558076 creator A5053445608 @default.
- W2909558076 creator A5070989428 @default.
- W2909558076 creator A5073092107 @default.
- W2909558076 date "2019-01-09" @default.
- W2909558076 modified "2023-10-18" @default.
- W2909558076 title "Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers" @default.
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- W2909558076 doi "https://doi.org/10.3390/nu11010125" @default.
- W2909558076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6356543" @default.
- W2909558076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30634497" @default.