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• W2909599239 abstract "Variability of Urinary Bisphenol-A Levels during Pregnancy and Risk of Preterm BirthAbstract Number:2480 David Cantonwine*, Kelly Ferguson, Bhramar Mukherjee, Thomas McElrath, John Meeker David Cantonwine* Division of Maternal-Fetal Medicine, Brigham & Women's Hospital, United States, E-mail Address: [email protected] Search for more papers by this author , Kelly Ferguson Department of Environmental Health Sciences, University of Michigan School of Public Health, United States, E-mail Address: [email protected] Search for more papers by this author , Bhramar Mukherjee Department of Biostatistics, University of Michigan School of Public Health, United States, E-mail Address: [email protected] Search for more papers by this author , Thomas McElrath Division of Maternal-Fetal Medicine, Brigham & Women's Hospital, United States, E-mail Address: [email protected] Search for more papers by this author , and John Meeker Department of Environmental Health Sciences, University of Michigan School of Public Health, United States, E-mail Address: [email protected] Search for more papers by this author AbstractBackground Preterm birth (PTB), a leading cause of infant mortality and morbidity, has a complex etiology with a multitude of interacting causes and risk factors. The role of environmental contaminants, particularly bisphenol A (BPA), is understudied with regards to PTB.Objectives In the present study we examined the relationship between longitudinally measured BPA exposure during gestation and PTB.Methods A nested case-control study was performed from women enrolled in a prospective birth cohort study at Brigham and Women’s Hospital in Boston during 2006-2008. Urine samples were analyzed for BPA concentrations at a minimum of three time points during pregnancy on 130 cases of PTB and 352 randomly assigned controls. Clinical classifications of PTB were defined as ‘spontaneous’, which was preceded by spontaneous preterm labor or preterm premature rupture of membranes, or ‘placental’, which was preceded by preeclampsia or intrauterine growth restriction.Results Geometric mean concentrations of BPA did not differ significantly between cases and controls. Intraclass correlation coefficients for specific gravity-adjusted BPA indicated low temporal reliability [0.21 (95%CI: 0.16,0.27)]. In adjusted models, urinary BPA averaged across pregnancy was not significantly associated with odds of PTB. When examining clinical classifications of PTB, urinary BPA late in pregnancy was significantly associated with an increased odds of delivering a spontaneous PTB.Conclusions These results provide little evidence of a relationship between BPA exposure and prematurity, though further research may be warranted given the significant adverse finding with spontaneous PTB and urinary BPA concentration in late pregnancy." @default.
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• W2909599239 date "2014-10-20" @default.
• W2909599239 modified "2023-09-26" @default.
• W2909599239 title "Variability of Urinary Bisphenol-A Levels during Pregnancy and Risk of Preterm Birth" @default.
• W2909599239 doi "https://doi.org/10.1289/isee.2014.p1-018" @default.
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