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• W2909636369 abstract "Traditional chemotherapy drugs aim to fight cancer cell proliferation, targeting DNA or mechanisms of mitosis. Unfortunately, some chemotherapy drugs fail due to innate or acquired drug resistance. Clinical cancer therapy regimens employ multiple drugs to prevent chemoresistance and limit adverse effects for the patient. One significant reason for chemoresistance is an increased drug efflux, primarily caused by the presence (or overexpression) of ATP-binding cassette (ABC) transporters across the cell membrane which “pump out” the chemotherapy drug. Several classic chemotherapies including doxorubicin (adriamycin), paclitaxel, topotecan, and mitoxantrone are known substrates of certain subclasses of ABC transporters. This presents a problem for the efficacy of the anticancer treatment if the tumor develops overexpression of these transporters as a mechanism of resistance. The epidermal growth factor receptor (EGFR) family and the human EGFR 2 (HER2) of the receptor tyrosine kinases play essential roles in regulating cell proliferation, survival, and differentiation. Because of their pivotal role in cellular function and growth, many inhibitors of EGFR and HER2 have been approved as targeted treatments for many diseases and cancers. Many of these inhibitors also play an interesting role in cancer therapy as they have been found to sensitize chemoresistant tumors and rescue cancer cells those have stopped responding to chemotherapy treatments. This chapter will explore the EGFR and HER2 inhibitors gefitinib, erlotinib, lapatinib, afatinib, pelitinib, and osimertinib as promising clinical tools in sensitizing chemoresistant tumors." @default.
• W2909636369 created "2019-01-25" @default.
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• W2909636369 date "2019-01-01" @default.
• W2909636369 modified "2023-09-26" @default.
• W2909636369 title "EGFR and HER2 Inhibitors as Sensitizing Agents for Cancer Chemotherapy" @default.
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• W2909636369 doi "https://doi.org/10.1016/b978-0-12-816435-8.00001-8" @default.
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