FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909685808> ?p ?o ?g. }

• W2909685808 abstract "Abstract Reverse gyrase (RG) is the only protein found ubiquitously in hyperthermophilic organisms, but absent from mesophiles. As such, its simple presence or absence allows us to deduce information about the optimal growth temperature of long-extinct organisms, even as far as the last universal common ancestor of extant life (LUCA). The growth environment and gene content of the LUCA has long been a source of debate in which RG often features. In an attempt to settle this debate, we carried out an exhaustive search for RG proteins, generating the largest RG dataset to date. Comprising 376 sequences, our dataset allows for phylogenetic reconstructions of RG with unprecedented size and detail. These RG phylogenies are strikingly different from those of known LUCA-encoded proteins, even when using the same set of species. Unlike LUCA-encoded proteins, RG does not form monophyletic archaeal and bacterial clades, suggesting RG emergence after the formation of these domains, and/or significant horizontal gene transfer. Even more strikingly, the branch lengths separating archaeal and bacterial groups are very short, inconsistent with the tempo of evolution from the time of the LUCA. Despite this, phylogenies limited to archaeal RG resolve most archaeal phyla, suggesting predominantly vertical evolution since the time of the last archaeal ancestor. In contrast, bacterial RG indicates emergence after the last bacterial ancestor followed by significant horizontal transfer. Taken together, these results suggest a non-hyperthermophilic LUCA and bacterial ancestor, with hyperthermophily emerging early in the evolution of the archaeal and bacterial domains." @default.
• W2909685808 created "2019-01-25" @default.
• W2909685808 creator A5055956018 @default.
• W2909685808 creator A5091702193 @default.
• W2909685808 date "2019-01-20" @default.
• W2909685808 modified "2023-09-23" @default.
• W2909685808 title "Positively twisted: The complex evolutionary history of Reverse Gyrase suggests a non-hyperthermophilic Last Universal Common Ancestor" @default.
• W2909685808 cites W1546864960 @default.
• W2909685808 cites W1766380752 @default.
• W2909685808 cites W1923326679 @default.
• W2909685808 cites W1939911045 @default.
• W2909685808 cites W1969141930 @default.
• W2909685808 cites W1976937887 @default.
• W2909685808 cites W1983315433 @default.
• W2909685808 cites W1992702958 @default.
• W2909685808 cites W1998172162 @default.
• W2909685808 cites W2011223597 @default.
• W2909685808 cites W2013215293 @default.
• W2909685808 cites W2015763180 @default.
• W2909685808 cites W2023218781 @default.
• W2909685808 cites W2023380041 @default.
• W2909685808 cites W2025256609 @default.
• W2909685808 cites W2028209928 @default.
• W2909685808 cites W2031611770 @default.
• W2909685808 cites W2040461302 @default.
• W2909685808 cites W2046961642 @default.
• W2909685808 cites W2056570457 @default.
• W2909685808 cites W2062275978 @default.
• W2909685808 cites W2069182996 @default.
• W2909685808 cites W2075563069 @default.
• W2909685808 cites W2078610498 @default.
• W2909685808 cites W2083583008 @default.
• W2909685808 cites W2087520649 @default.
• W2909685808 cites W2092592451 @default.
• W2909685808 cites W2094465124 @default.
• W2909685808 cites W2097882389 @default.
• W2909685808 cites W2098133127 @default.
• W2909685808 cites W2103311526 @default.
• W2909685808 cites W2111647009 @default.
• W2909685808 cites W2127556561 @default.
• W2909685808 cites W2131050697 @default.
• W2909685808 cites W2134909929 @default.
• W2909685808 cites W2136437557 @default.
• W2909685808 cites W2137015675 @default.
• W2909685808 cites W2138122982 @default.
• W2909685808 cites W2141052558 @default.
• W2909685808 cites W2146754116 @default.
• W2909685808 cites W2148698435 @default.
• W2909685808 cites W2150229780 @default.
• W2909685808 cites W2158266834 @default.
• W2909685808 cites W2164541345 @default.
• W2909685808 cites W2167128189 @default.
• W2909685808 cites W2169779547 @default.
• W2909685808 cites W2170678884 @default.
• W2909685808 cites W2171707557 @default.
• W2909685808 cites W2179988958 @default.
• W2909685808 cites W2336330109 @default.
• W2909685808 cites W2376573086 @default.
• W2909685808 cites W2411213844 @default.
• W2909685808 cites W2437388877 @default.
• W2909685808 cites W2506780551 @default.
• W2909685808 cites W2614081736 @default.
• W2909685808 cites W2626157953 @default.
• W2909685808 cites W2724445153 @default.
• W2909685808 cites W2743255823 @default.
• W2909685808 cites W2801190596 @default.
• W2909685808 cites W2917207851 @default.
• W2909685808 cites W2952889118 @default.
• W2909685808 cites W4210702584 @default.
• W2909685808 doi "https://doi.org/10.1101/524215" @default.
• W2909685808 hasPublicationYear "2019" @default.
• W2909685808 type Work @default.
• W2909685808 sameAs 2909685808 @default.
• W2909685808 citedByCount "4" @default.
• W2909685808 countsByYear W29096858082019 @default.
• W2909685808 countsByYear W29096858082020 @default.
• W2909685808 crossrefType "posted-content" @default.
• W2909685808 hasAuthorship W2909685808A5055956018 @default.
• W2909685808 hasAuthorship W2909685808A5091702193 @default.
• W2909685808 hasBestOaLocation W29096858081 @default.
• W2909685808 hasConcept C104317684 @default.
• W2909685808 hasConcept C12326286 @default.
• W2909685808 hasConcept C166957645 @default.
• W2909685808 hasConcept C178300618 @default.
• W2909685808 hasConcept C193252679 @default.
• W2909685808 hasConcept C197583594 @default.
• W2909685808 hasConcept C205649164 @default.
• W2909685808 hasConcept C2780422015 @default.
• W2909685808 hasConcept C44465124 @default.
• W2909685808 hasConcept C54355233 @default.
• W2909685808 hasConcept C550995028 @default.
• W2909685808 hasConcept C78458016 @default.
• W2909685808 hasConcept C86803240 @default.
• W2909685808 hasConcept C90132467 @default.
• W2909685808 hasConcept C91066513 @default.
• W2909685808 hasConcept C92938381 @default.
• W2909685808 hasConceptScore W2909685808C104317684 @default.
• W2909685808 hasConceptScore W2909685808C12326286 @default.
• W2909685808 hasConceptScore W2909685808C166957645 @default.
• W2909685808 hasConceptScore W2909685808C178300618 @default.

• next