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- W2909717416 abstract "A major question in cell and cancer biology is concerned with understanding the flow of information from gene to protein. Indeed, many studies indicate that the proteome can be decoupled from the transcriptome. A major source of this decoupling is post-transcriptional regulation. The eukaryotic translation initiation factor eIF4E serves as an excellent example of a protein that can modulate the proteome at the post-transcriptional level. eIF4E is elevated in many cancers thus highlighting the relevance of this mode of control to biology. In this review, we provide a brief overview of various functions of eIF4E in RNA metabolism e.g. in nuclear-cytoplasmic RNA export, translation, RNA stability and/or sequestration. We focus on the modalities of eIF4E regulation at the biochemical and particularly structural level. In this instance, we describe not only the importance for the m7Gcap eIF4E interaction but also of recently discovered non-traditional RNA-eIF4E interactions as well as cap-independent activities of eIF4E. Further, we describe several distinct structural modalities used by the cell and some viruses to regulate or co-opt eIF4E, substantially extending the types of proteins that can regulate eIF4E from the traditional eIF4E-binding proteins (e.g. 4E-BP1 and eIF4G). Finally, we provide an overview of the results of targeting eIF4E activity in the clinic." @default.
- W2909717416 created "2019-01-25" @default.
- W2909717416 creator A5046044002 @default.
- W2909717416 creator A5076557834 @default.
- W2909717416 creator A5089167705 @default.
- W2909717416 date "2019-05-20" @default.
- W2909717416 modified "2023-10-18" @default.
- W2909717416 title "Biochemical and Structural Insights into the Eukaryotic Translation Initiation Factor eIF4E" @default.
- W2909717416 cites W1520611165 @default.
- W2909717416 cites W1551679579 @default.
- W2909717416 cites W1608233475 @default.
- W2909717416 cites W1675243257 @default.
- W2909717416 cites W1922815468 @default.
- W2909717416 cites W1964675052 @default.
- W2909717416 cites W1966275499 @default.
- W2909717416 cites W1966985603 @default.
- W2909717416 cites W1968622004 @default.
- W2909717416 cites W1968919723 @default.
- W2909717416 cites W1974431355 @default.
- W2909717416 cites W1976749028 @default.
- W2909717416 cites W1978686930 @default.
- W2909717416 cites W1981461598 @default.
- W2909717416 cites W1981667075 @default.
- W2909717416 cites W1982800257 @default.
- W2909717416 cites W1987452803 @default.
- W2909717416 cites W1988640094 @default.
- W2909717416 cites W1989000331 @default.
- W2909717416 cites W1993287040 @default.
- W2909717416 cites W1993602050 @default.
- W2909717416 cites W1994713811 @default.
- W2909717416 cites W1996084661 @default.
- W2909717416 cites W1998755101 @default.
- W2909717416 cites W2001953649 @default.
- W2909717416 cites W2005056727 @default.
- W2909717416 cites W2006150047 @default.
- W2909717416 cites W2007765039 @default.
- W2909717416 cites W2018632645 @default.
- W2909717416 cites W2029400818 @default.
- W2909717416 cites W2033171415 @default.
- W2909717416 cites W2033489247 @default.
- W2909717416 cites W2035445900 @default.
- W2909717416 cites W2036872180 @default.
- W2909717416 cites W2037532701 @default.
- W2909717416 cites W2038423179 @default.
- W2909717416 cites W2040579733 @default.
- W2909717416 cites W2056755041 @default.
- W2909717416 cites W2057906496 @default.
- W2909717416 cites W2065825082 @default.
- W2909717416 cites W2066018734 @default.
- W2909717416 cites W2066652018 @default.
- W2909717416 cites W2069305926 @default.
- W2909717416 cites W2069641384 @default.
- W2909717416 cites W2071739990 @default.
- W2909717416 cites W2071907263 @default.
- W2909717416 cites W2073424121 @default.
- W2909717416 cites W2075362559 @default.
- W2909717416 cites W2085664732 @default.
- W2909717416 cites W2086938346 @default.
- W2909717416 cites W2087415650 @default.
- W2909717416 cites W2088563552 @default.
- W2909717416 cites W2095636501 @default.
- W2909717416 cites W2098716539 @default.
- W2909717416 cites W2099136664 @default.
- W2909717416 cites W2108663777 @default.
- W2909717416 cites W2109838706 @default.
- W2909717416 cites W2112519486 @default.
- W2909717416 cites W2116115990 @default.
- W2909717416 cites W2121696558 @default.
- W2909717416 cites W2122438081 @default.
- W2909717416 cites W2125471952 @default.
- W2909717416 cites W2127654183 @default.
- W2909717416 cites W2129201076 @default.
- W2909717416 cites W2130410721 @default.
- W2909717416 cites W2131856634 @default.
- W2909717416 cites W2132519593 @default.
- W2909717416 cites W2137238711 @default.
- W2909717416 cites W2138338180 @default.
- W2909717416 cites W2145284274 @default.
- W2909717416 cites W2147563857 @default.
- W2909717416 cites W2148915086 @default.
- W2909717416 cites W2149546612 @default.
- W2909717416 cites W2150635042 @default.
- W2909717416 cites W2155984955 @default.
- W2909717416 cites W2157338279 @default.
- W2909717416 cites W2161011316 @default.
- W2909717416 cites W2163107196 @default.
- W2909717416 cites W2169727429 @default.
- W2909717416 cites W2338878406 @default.
- W2909717416 cites W2342976696 @default.
- W2909717416 cites W2358953241 @default.
- W2909717416 cites W2538475718 @default.
- W2909717416 cites W2544544592 @default.
- W2909717416 cites W2586235837 @default.
- W2909717416 cites W2597563837 @default.
- W2909717416 cites W2605316453 @default.
- W2909717416 cites W2735357942 @default.
- W2909717416 cites W2757843953 @default.
- W2909717416 cites W2767890943 @default.