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- W2909725539 abstract "Aim: To assess the cost–effectiveness of UGT1A1*6/*28 genotyping compared with no genotyping or no dose adjustment before irinotecan administration in China. Materials & methods: A decision tree model was developed to evaluate costs and health outcomes represented as quality-adjusted life years gained. Model inputs for the frequency of genotypes, the probability of neutropenia under FOLFIRI chemotherapy and direct costs and utilities were obtained from published sources. One-way sensitivity analyses were performed. Results: The strategy of genotyping with dose reduction dominated all remaining strategies. Compared with the strategies of no genotyping and genotyping with unchanged dose, it resulted in only marginal quality-adjusted life year increases (0.0011 and 0.0012) but a cost reduction of $651.12 and $805.22 per patient, respectively. One-way sensitivity analyses revealed that the model was relatively robust. Conclusion: UGT1A1*6/*28 genotyping was cost saving for Chinese colorectal cancer patients." @default.
- W2909725539 created "2019-01-25" @default.
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- W2909725539 date "2019-03-01" @default.
- W2909725539 modified "2023-09-25" @default.
- W2909725539 title "Cost–effectiveness analysis of <i>UGT1A1*6/*28</i> genotyping for preventing FOLFIRI-induced severe neutropenia in Chinese colorectal cancer patients" @default.
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- W2909725539 doi "https://doi.org/10.2217/pgs-2018-0138" @default.
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