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- W2909726850 abstract "e21513 Background: MPNST (Malignant Peripheral Nerve Sheath Tumor) is one of the most frequent causes of death in patients (pts) with NF1. Early detection is crucial, as complete surgical resection is the only curative treatment. However, diagnosis between BPNST (Benign Peripheral Nerve Sheath Tumor) and MPNST by clinical symptoms or conventional CT and MRI (including whole-body MRI protocol) is difficult. PET/CT, with a T/L (Tumor/Liver) SUVmax ratio > 1.5, provides a high negative predictive value but it is not specific enough for NF1-related MPNST diagnosis. Thus, a formal proof of malignant transformation by histological analysis is necessary before surgical excision, which could be mutilating. We aimed to investigate the effectiveness and complications of PET/CT-guided percutaneous biopsy (PET/CT GPB) technique for MPNST NF1-related diagnosis. Methods: PET/CT GPB procedures performed on 26 NF1 pts with a clinical suspicion of MPNST and a suspect lesion on PET/CT (T/L SUVmaxratio > 1.5) were retrospec..." @default.
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- W2909726850 date "2015-05-20" @default.
- W2909726850 modified "2023-09-29" @default.
- W2909726850 title "PET/CT-guided percutaneous biopsy for diagnosis of MPNST in Neufibromatosis Type 1 (NF1)." @default.
- W2909726850 doi "https://doi.org/10.1200/jco.2015.33.15_suppl.e21513" @default.
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