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- W2909761749 abstract "Background Epitope spreading occurs prior to the clinical diagnosis of rheumatoid arthritis (RA), the number of peptide recognised and its titer increases remarkably as becoming close to the clinical diagnosis. However, the effect of multiple autoantibodies on the clinical outcome is not well known. Objectives This study is to investigate the association between the number of autoantibodies at presentation and the clinical aspects in Korean patients with early RA. Methods The number of baseline autoantibody (rheumatoid factor, anticitrullinated peptide antibodies (ACPA), and anti-carbamylated protein antibodies (anti-CarP)) was analysed in the Korean Intensive Management of Early Rheumatoid Arthritis (KIMERA) cohort. All patients were disease-modifying antirheumatic drug (DMARD)-naive RA patients with symptom duration less than 1 year. They were intensively treated by adjusting medications every 4 weeks, and treated to target as DAS28 of Results A total of 128 patients were included, seronegative patients showed higher baseline physician global VAS (7.3 vs 4.7 vs 4.6 vs 4.4, p=0.005) and DAS28-ESR (7.1 vs 4.5 vs 5.0 vs 4.7, p=0.003) than patients with 1, 2, and 3 autoantibodies. Also seronegative patients showed a trend to have higher baseline HAQ score and pain VAS. After intensive treatment, there were no differences in remission rate and DAS28-ESR at 12, 24, and 36 months. Conclusions Seronegative patients showed higher levels of baseline inflammation than seropositive patients. However, they had favourable treatment response with rapid improvement which resulted in excellent clinical outcome. Disclosure of Interest None declared" @default.
- W2909761749 created "2019-01-25" @default.
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- W2909761749 date "2018-06-01" @default.
- W2909761749 modified "2023-09-24" @default.
- W2909761749 title "FRI0069 Difference of clinical implication regarding the numbers of autoantibodies at presentation in korean patients with early rheumatoid arthritis" @default.
- W2909761749 doi "https://doi.org/10.1136/annrheumdis-2018-eular.4354" @default.
- W2909761749 hasPublicationYear "2018" @default.
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