Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909764647> ?p ?o ?g. }
- W2909764647 endingPage "308" @default.
- W2909764647 startingPage "304" @default.
- W2909764647 abstract "Abstract Harmful effects of elevated levels of catecholamines are mediated by various mechanisms, including gene transcription and formation of oxidation products. The aim of this study was to see whether the molecular mechanisms underlying the damaging action of adrenaline on DNA are mediated by reactive oxygen species (ROS). To do that, we exposed human whole blood cells to 10 μmol L -1 adrenaline or 50 μmol L -1 H 2 O 2 (used as positive control) that were separately pre-treated or post-treated with 500 μmol L -1 of quercetin, a scavenger of free radicals. Quercetin significantly reduced DNA damage in both pre- and post-treatment protocols, which suggests that adrenaline mainly acts via the production of ROS. This mechanism is also supported by gradual lowering of adrenaline and H 2 O 2 -induced DNA damage 15, 30, 45, and 60 min after treatment. Our results clearly show that DNA repair mechanisms are rather effective against ROS-mediated DNA damage induced by adrenaline." @default.
- W2909764647 created "2019-01-25" @default.
- W2909764647 creator A5011774166 @default.
- W2909764647 creator A5032243432 @default.
- W2909764647 creator A5039561002 @default.
- W2909764647 creator A5045478903 @default.
- W2909764647 creator A5047057719 @default.
- W2909764647 creator A5085216888 @default.
- W2909764647 date "2018-12-01" @default.
- W2909764647 modified "2023-09-26" @default.
- W2909764647 title "Assessment of adrenaline-induced DNA damage in whole blood cells with the comet assay" @default.
- W2909764647 cites W1969887535 @default.
- W2909764647 cites W1977263017 @default.
- W2909764647 cites W1986998491 @default.
- W2909764647 cites W1991289128 @default.
- W2909764647 cites W1996417742 @default.
- W2909764647 cites W2002056855 @default.
- W2909764647 cites W2005232615 @default.
- W2909764647 cites W2008034840 @default.
- W2909764647 cites W2011382025 @default.
- W2909764647 cites W2014578038 @default.
- W2909764647 cites W2024284783 @default.
- W2909764647 cites W2028933689 @default.
- W2909764647 cites W2033984972 @default.
- W2909764647 cites W2034141381 @default.
- W2909764647 cites W2039158807 @default.
- W2909764647 cites W2056051410 @default.
- W2909764647 cites W2059703237 @default.
- W2909764647 cites W2059802512 @default.
- W2909764647 cites W2092629964 @default.
- W2909764647 cites W2094127775 @default.
- W2909764647 cites W2094285631 @default.
- W2909764647 cites W2100678706 @default.
- W2909764647 cites W2103690977 @default.
- W2909764647 cites W2121921780 @default.
- W2909764647 cites W2127181172 @default.
- W2909764647 cites W2129601196 @default.
- W2909764647 cites W2145906307 @default.
- W2909764647 cites W2148561456 @default.
- W2909764647 cites W2150217973 @default.
- W2909764647 cites W2153241517 @default.
- W2909764647 cites W2249759096 @default.
- W2909764647 cites W2281939227 @default.
- W2909764647 cites W2589314227 @default.
- W2909764647 doi "https://doi.org/10.2478/aiht-2018-69-3154" @default.
- W2909764647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30864376" @default.
- W2909764647 hasPublicationYear "2018" @default.
- W2909764647 type Work @default.
- W2909764647 sameAs 2909764647 @default.
- W2909764647 citedByCount "4" @default.
- W2909764647 countsByYear W29097646472020 @default.
- W2909764647 countsByYear W29097646472022 @default.
- W2909764647 countsByYear W29097646472023 @default.
- W2909764647 crossrefType "journal-article" @default.
- W2909764647 hasAuthorship W2909764647A5011774166 @default.
- W2909764647 hasAuthorship W2909764647A5032243432 @default.
- W2909764647 hasAuthorship W2909764647A5039561002 @default.
- W2909764647 hasAuthorship W2909764647A5045478903 @default.
- W2909764647 hasAuthorship W2909764647A5047057719 @default.
- W2909764647 hasAuthorship W2909764647A5085216888 @default.
- W2909764647 hasBestOaLocation W29097646471 @default.
- W2909764647 hasConcept C139066938 @default.
- W2909764647 hasConcept C143425029 @default.
- W2909764647 hasConcept C153911025 @default.
- W2909764647 hasConcept C185592680 @default.
- W2909764647 hasConcept C2778004101 @default.
- W2909764647 hasConcept C2780358455 @default.
- W2909764647 hasConcept C2781263971 @default.
- W2909764647 hasConcept C48349386 @default.
- W2909764647 hasConcept C552990157 @default.
- W2909764647 hasConcept C55493867 @default.
- W2909764647 hasConcept C56783068 @default.
- W2909764647 hasConcept C86803240 @default.
- W2909764647 hasConcept C98274493 @default.
- W2909764647 hasConceptScore W2909764647C139066938 @default.
- W2909764647 hasConceptScore W2909764647C143425029 @default.
- W2909764647 hasConceptScore W2909764647C153911025 @default.
- W2909764647 hasConceptScore W2909764647C185592680 @default.
- W2909764647 hasConceptScore W2909764647C2778004101 @default.
- W2909764647 hasConceptScore W2909764647C2780358455 @default.
- W2909764647 hasConceptScore W2909764647C2781263971 @default.
- W2909764647 hasConceptScore W2909764647C48349386 @default.
- W2909764647 hasConceptScore W2909764647C552990157 @default.
- W2909764647 hasConceptScore W2909764647C55493867 @default.
- W2909764647 hasConceptScore W2909764647C56783068 @default.
- W2909764647 hasConceptScore W2909764647C86803240 @default.
- W2909764647 hasConceptScore W2909764647C98274493 @default.
- W2909764647 hasIssue "4" @default.
- W2909764647 hasLocation W29097646471 @default.
- W2909764647 hasLocation W29097646472 @default.
- W2909764647 hasLocation W29097646473 @default.
- W2909764647 hasLocation W29097646474 @default.
- W2909764647 hasLocation W29097646475 @default.
- W2909764647 hasLocation W29097646476 @default.
- W2909764647 hasLocation W29097646477 @default.
- W2909764647 hasOpenAccess W2909764647 @default.
- W2909764647 hasPrimaryLocation W29097646471 @default.
- W2909764647 hasRelatedWork W1526562437 @default.