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• W2909805543 abstract "Increasing number of microRNAs (miRNAs) have been reported to play an important role in the development and progression of non-small cell lung cancer (NSCLC). In particular, microRNA-497-5p (miR-497-5p) has been proposed as a tumor suppressor miRNA in human cancers. However, the role of miR-497-5p and its potential molecular mechanism associated with NSCLC are less studied. Therefore, the role of miR-497-5p in the pathogenesis of NSCLC was investigated. In the present study, the expression of miR-497-5p was significantly downregulated in NSCLC. Moreover, overexpression of miR-497-5p inhibited the proliferation and invasion of NSCLC cells by suppressing FGF2. In addition, FGF2 was a downstream target of miR-497-5p in NSCLC. FGF2 was upregulated in NSCLC promoting cell proliferation and invasion. Overexpression of FGF2 impaired the inhibitory effect of miR-497-5p in NSCLC. Taken together, these results demonstrate that miR-497-5p is a tumor suppressor miRNA and demonstrate its potential for future use in the treatment of human NSCLC." @default.
• W2909805543 created "2019-01-25" @default.
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• W2909805543 date "2019-01-21" @default.
• W2909805543 modified "2023-10-18" @default.
• W2909805543 title "MicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2" @default.
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• W2909805543 doi "https://doi.org/10.3892/ol.2019.9954" @default.
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