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- W2909858700 abstract "Recently, our group demonstrated that immobilized VEGF can capture flowing endothelial cells (ECs) from the blood in vitro and promote endothelialization and patency of acellular tissue-engineered vessels (A-TEVs) into the arterial system of an ovine animal model. Here, we demonstrate implantability of submillimeter diameter heparin and VEGF-decorated A-TEVs in a mouse model and discuss the cellular and immunologic response. At 1 mo postimplantation, the graft lumen was fully endothelialized, as shown by expression of EC markers such as CD144, eNOS, CD31, and VEGFR2. Interestingly, the same cells coexpressed leukocyte/macrophage (Mϕ) markers CD14, CD16, VEGFR1, CD38, and EGR2. Notably, there was a stark difference in the cellular makeup between grafts containing VEGF and those containing heparin alone. In VEGF-containing grafts, infiltrating monocytes (MCs) converted into anti-inflammatory M2-Mϕs, and the grafts developed well-demarcated luminal and medial layers resembling those of native arteries. In contrast, in grafts containing only heparin, MCs converted primarily into M1-Mϕs, and the endothelial and smooth muscle layers were not well defined. Our results indicate that VEGF may play an important role in regulating A-TEV patency and regeneration, possibly by regulating the inflammatory response to the implants.-Smith, R. J., Jr., Yi, T., Nasiri, B., Breuer, C. K., Andreadis, S. T. Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response." @default.
- W2909858700 created "2019-01-25" @default.
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- W2909858700 date "2019-01-10" @default.
- W2909858700 modified "2023-10-17" @default.
- W2909858700 title "Implantation of VEGF‐functionalized cell‐free vascular grafts: regenerative and immunological response" @default.
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- W2909858700 doi "https://doi.org/10.1096/fj.201801856r" @default.
- W2909858700 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6436645" @default.
- W2909858700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30629890" @default.
- W2909858700 hasPublicationYear "2019" @default.
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